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Regulation of the expression of MKP-1 and MKP-2 by ERK MAP kinases in macrophages following LPS stimulation (P1214)

Autor: Yusen Liu, Jianjing Xue, Lyn Wancket, Yasaman Shakibi, Leif Nelin, W. Frazier

Publikováno v: The Journal of Immunology. 190:138.5-138.5

Although the MKP family plays an important role during host defense, the regulation of MKPs is poorly understood. We studied the expression of MKP-1 and MKP-2 in RAW264.7 cells during LPS stimulation. We found that pretreatment of cells with U0126 (a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::668176369d040017287b84af86d46e63
https://doi.org/10.4049/jimmunol.190.supp.138.5

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Knockout of mitogen-activated protein kinase phosphatase (Mkp)-1 exacerbates colitis development in interleukin-10-deficient mice (120.21)

Autor: Yusen Liu, Ranyia Matta, John Barnard, Lyn Wancket, Jing Yan, Jessica Grieves, W. Joshua Frazier, Leif Nelin, Andrew Cato

Publikováno v: The Journal of Immunology. 188:120.21-120.21

Il-10-/- mice develop colitis associated with exaggerated Th1/Th17 responses. Mkp-1 is a negative regulator of MAPKs, and its expression is enhanced by IL-10. To understand the role of Mkp-1 in the regulation of mucosal immune responses, we studied t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::df5fcdee2fc2efeb0c61c3ea8db011bb
https://doi.org/10.4049/jimmunol.188.supp.120.21

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Glutathione reductase facilitates host defense by sustaining phagocytic oxidative burst and promoting the development of neutrophil extracellular traps (172.3)

Autor: Yusen Liu, Jing Yan, Xiaomei Meng, Lyn Wancket, Katherine Lintner, Leif Nelin, Bernadette Chen, Kevin Francis, Charles Smith, Lynette Rogers

Publikováno v: The Journal of Immunology. 188:172.3-172.3

Glutathione reductase (Gsr) catalyzes the reduction of glutathione disulfide to glutathione. Since Gsr has been implicated in the oxidative burst in human PMN, we hypothesized that Gsr-null mice would exhibit marked defects during the immune response

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5c6294236d141be120c70a4419aba11d
https://doi.org/10.4049/jimmunol.188.supp.172.3

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The pivotal role of glutathione reductase in host defense against Gram-negative bacteria (111.25)

Autor: Jing Yan, Xiaomei Meng, Lyn Wancket, Katherine Lintner, Haiwa Wu, Leif Nelin, Bernadatte Chen, Charles Smith, Lynette Rogers, Yusen Liu

Publikováno v: The Journal of Immunology. 186:111.25-111.25

Glutathione reductase (Gsr) is an enzyme that reduces glutathione disulfide to the sulfhydryl form, a major cellular antioxidant. Oxidative burst plays an important role in pathogen killing and initiation of inflammation. Proper redox regulation is c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::fd94e552dd7e3ec3395e1f7b073f996a
https://doi.org/10.4049/jimmunol.186.supp.111.25

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MAP kinase phosphatase (MKP)-1 in the innate immune response to influenza infection (42.4)

Autor: Lyn Wancket, Stephanie de Oliveira, Yusen Liu

Publikováno v: The Journal of Immunology. 184:42.4-42.4

MKP-1 is a critical negative regulator of p38 and JNK MAP kinases. While loss of Mkp-1 function enhances cytokine production after bacterial challenge, little is known about the role of Mkp-1 in the innate immune response to viral infections. In this

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7ae245b167b5f04b2187cf06cebacf24
https://doi.org/10.4049/jimmunol.184.supp.42.4

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Role of MKP-1 in an IL-10 knockout murine inflammatory bowel disease model (47.7)

Autor: Lyn Wancket, Ranyia Matta, John Barnard, Jessica Grieves, Leif Nelin, Andrew Cato, Yusen Liu

Publikováno v: The Journal of Immunology. 184:47.7-47.7

IBD is a chronic intestinal inflammatory disease that often has extra-intestinal manifestations. We examined the role of the MAPK phosphatase Mkp-1 in a mouse model of IBD. Mkp-1+/+/Il-10+/+, Mkp-1-/-/Il-10+/+, Mkp-1+/+/Il-10-/-, and Mkp-1-/-/Il-10-/

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b11639edfad2eeeb70cbf37e81514792
https://doi.org/10.4049/jimmunol.184.supp.47.7

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