Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Lyn Rosenbrier Ribeiro"'
Autor:
Avid M. Afzal, Ian P. Barrett, Samantha Jayne Hughes, Lyn Rosenbrier-Ribeiro, Danilo Basili, Kathryn A. Giblin, Andreas Bender, Nigel Greene
Publikováno v:
Chemical Research in Toxicology. 34:438-451
To improve our ability to extrapolate preclinical toxicity to humans, there is a need to understand and quantify the concordance of adverse events (AEs) between animal models and clinical studies. In the present work, we discovered 3011 statistically
SARS-CoV-2 comprehensive receptor profiling: mechanistic insight to drive new therapeutic strategies
Autor:
Jo Soden, Sarah Mv Brockbank, Lucy Coverley, Helen E. Thomas, Jim Freeth, W Mark Abbott, Lyn Rosenbrier Ribeiro, Raquel Faba-Rodriguez, Jenni Delight, Catherine Geh
Here we describe a hypothesis free approach to screen for interactions of SARS-CoV-2 spike (S) protein with human cell surface receptors. We used a library screening approach to detect binding interactions across one of the largest known panels of me
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6526ed0c8f0b1a7d9e496dfbfe2eb929
https://doi.org/10.1101/2021.03.11.434937
https://doi.org/10.1101/2021.03.11.434937
Autor:
José A. Esteban, Lyn Rosenbrier Ribeiro, Luísa Cortes, Luís Ribeiro, Bárbara Oliveiros, Mário Jorge da Silva Carvalho, Tatiana Catarino, Patricio Opazo, Sandra D. Santos, Daniel Choquet, Ana Luísa Carvalho, João Peça
Publikováno v:
Science Signaling
Digital.CSIC. Repositorio Institucional del CSIC
instname
Science Signaling, American Association for the Advancement of Science, 2021, 14 (670), ⟨10.1126/scisignal.abb1953⟩
Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP
Digital.CSIC. Repositorio Institucional del CSIC
instname
Science Signaling, American Association for the Advancement of Science, 2021, 14 (670), ⟨10.1126/scisignal.abb1953⟩
Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP
The biological signals of hunger, satiety, and memory are interconnected. The role of the hormone ghrelin in regulating feeding and memory makes ghrelin receptors attractive targets for associated disorders. We investigated the effects of the high li
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60af8f155cac13ca492f04f8d43865b4
https://hdl.handle.net/10316/93152
https://hdl.handle.net/10316/93152
Autor:
Friedemann Schmidt, Stephen Jenkinson, Annie Delaunois, Lyn Rosenbrier Ribeiro, Jean-Pierre Valentin
Publikováno v:
Journal of pharmacological and toxicological methods. 105
Secondary pharmacological profiling is increasingly applied in pharmaceutical drug discovery to address unwanted pharmacological side effects of drug candidates before entering the clinic. Regulators, drug makers and patients share a demand for deep
Constitutive ghrelin receptor activity modulates AMPA receptor traffic and supports memory formation
Autor:
Ana Luísa Carvalho, Sandra D. Santos, José A. Esteban, Luísa Cortes, Lyn Rosenbrier Ribeiro, Daniel Choquet, João Peça, Tatiana Catarino, Patricio Opazo, Luís Ribeiro, Mário Jorge da Silva Carvalho
The ability of animals to store and retrieve food caches in the wild requires the integration of biological signals of hunger, satiety and memory. The role of ghrelin in regulating feeding and memory makes ghrelin receptors an important target to sha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f5d443b281154e72961dd06dfceb8b5b
https://doi.org/10.1101/2020.02.05.934463
https://doi.org/10.1101/2020.02.05.934463
Autor:
Jean-Pierre Valentin, Lyn Rosenbrier-Ribeiro, Stephen Jenkinson, Jean-Michel Guillon, Sonia Roberts, Duncan Armstrong, Friedemann Schmidt, Vivek J. Kadambi, Peri Ravikumar
Publikováno v:
Journal of Pharmacological and Toxicological Methods. 93:7-14
Introduction In 2015, IQ DruSafe conducted a survey of its membership to identify industry practices related to in vitro off target pharmacological profiling of small molecules. Methods An anonymous survey of 20 questions was submitted to IQ-DruSafe
Publikováno v:
Drug Discovery and Development ISBN: 9781315113470
Drug Discovery and Development
Drug Discovery and Development
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6179df3409ffca2af8455dea14b91d51
https://doi.org/10.1201/9781315113470-15
https://doi.org/10.1201/9781315113470-15
Autor:
R. Ian Storer, Lyn Rosenbrier Ribeiro
Publikováno v:
Toxicology and Applied Pharmacology. 317:41-50
Adenosine contributes to the pathophysiology of respiratory disease, and adenosine challenge leads to bronchospasm and dyspnoea in patients. The equilibrative nucleoside transporter 1 (ENT1) terminates the action of adenosine by removal from the extr
Autor:
Edward A. Hayter, Hans Clevers, Carolyn J. Karam, John S. O’Neill, Ryan Hamnett, Martin Reed, Peter Newham, Johanna E. Chesham, David A. Bechtold, Alessandra Stangherlin, Nathaniel P. Hoyle, Marrit Putker, Lyn Rosenbrier-Ribeiro, Priya Crosby, Elizabeth S. Maywood
Publikováno v:
Crosby, P, Hamnett, R, Putker, M, Hoyle, N P, Reed, M, Karam, C J, Maywood, E S, Stangherlin, A, Chesham, J E, Hayter, E A, Rosenbrier-Ribeiro, L, Newham, P, Clevers, H, Bechtold, D A & O'Neill, J S 2019, ' Insulin/IGF-1 Drives PERIOD Synthesis to Entrain Circadian Rhythms with Feeding Time ', Cell, vol. 177, no. 4, pp. 896-909.e20 . https://doi.org/10.1016/j.cell.2019.02.017
Cell, 177(4), 896-909.e20. Elsevier B.V.
Cell, 177(4), 896-909.e20. Elsevier B.V.
In mammals, endogenous circadian clocks sense and respond to daily feeding and lighting cues, adjusting internal ∼24 h rhythms to resonate with, and anticipate, external cycles of day and night. The mechanism underlying circadian entrainment to fee
Kinases make intriguing and attractive drug targets. Many are key players in disease-relevant pathways, and it is often relatively straightforward to develop screening assays and identify suitable chemical equity. While a large number of kinase inhib
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b9c0eaf7c527cf4d6584be8b005bbbcb
https://doi.org/10.1039/9781788013093-00237
https://doi.org/10.1039/9781788013093-00237