Zobrazeno 1 - 10
of 1 912
pro vyhledávání: '"Lyn R"'
Autor:
Pablo Iruzubieta, César Augusto Pinheiro Ferreira Alves, Aisha M. Al Shamsi, Gehad ElGhazali, Maha S. Zaki, Lorenzo Pinelli, Diego Lopergolo, Bernard P.H. Cho, Amy A. Jolly, Amna Al Futaisi, Fatema Al-Amrani, Jessica Galli, Elisa Fazzi, Katarina Vulin, Francisco Barajas-Olmos, Holger Hengel, Bayan Mohammed Aljamal, Vahideh Nasr, Farhad Assarzadegan, Michele Ragno, Luigi Trojano, Naomi Meave Ojeda, Arman Çakar, Silvia Bianchi, Francesca Pescini, Anna Poggesi, Amal Al Tenalji, Majid Aziz, Rahema Mohammad, Aziza Chedrawi, Nicola De Stefano, Giovanni Zifarelli, Ludger Schöls, Tobias B. Haack, Adriana Rebelo, Stephan Zuchner, Filiz Koc, Lyn R. Griffiths, Lorena Orozco, Karla García Helmes, Meisam Babaei, Peter Bauer, Won Chan Jeong, Ehsan Ghayoor Karimiani, Miriam Schmidts, Joseph G. Gleeson, Wendy K. Chung, Fowzan Sami Alkuraya, Bita Shalbafan, Hugh S. Markus, Henry Houlden, Reza Maroofian
Publikováno v:
EBioMedicine, Vol 107, Iss , Pp 105297- (2024)
Summary: Background: NOTCH3 encodes a transmembrane receptor critical for vascular smooth muscle cell function. NOTCH3 variants are the leading cause of hereditary cerebral small vessel disease (SVD). While monoallelic cysteine-involving missense var
Externí odkaz:
https://doaj.org/article/dcf457b6550e45488640bb16d06d46d7
Autor:
Larisa M. Haupt, Alison Haywood, Heidi G. Sutherland, Chieh Yu, Cassie L. Albury, Anushka Pharasi, Mathew Zunk, Rani George, Lyn R. Griffiths, Phillip Good, Janet Hardy
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-9 (2024)
Abstract Cancer pain is the most feared symptom at end of life. Methadone has advantages over other opioids but is associated with significant variability in clinical response, making dosing challenging in practice. OPRM1 is the most studied pharmaco
Externí odkaz:
https://doaj.org/article/d6837e2f2d844ba08dc46887310fae92
Autor:
Divya Mehta, Irene de Boer, Heidi G. Sutherland, Judith A. Pijpers, Charlene Bron, Charlotte Bainomugisa, Larisa M. Haupt, Arn M. J. M. van den Maagdenberg, Lyn R. Griffiths, Dale R. Nyholt, Gisela M. Terwindt
Publikováno v:
Clinical Epigenetics, Vol 15, Iss 1, Pp 1-12 (2023)
Abstract Background Chronic migraine, a highly disabling migraine subtype, affects nearly 2% of the general population. Understanding migraine chronification is vital for developing better treatment and prevention strategies. An important factor in t
Externí odkaz:
https://doaj.org/article/733e0f66098746629b8059295d7d35d8
Autor:
Guanglu Li, Shaojie Duan, International Headache Genetics Consortium (IHGC), Tao Zheng, Tiantian Zhu, Baoquan Qu, Lei Liu, Zunjing Liu, Verneri Anttila, Ville Artto, Andrea C Belin, Anna Bjornsdottir, Gyda Bjornsdottir, Dorret I Boomsma, Sigrid Børte, Mona A Chalmer, Daniel I Chasman, Bru Cormand, Ester Cuenca-Leon, George Davey-Smith, Irene de Boer, Martin Dichgans, Tonu Esko, Tobias Freilinger, Padhraig Gormley, Lyn R Griffiths, Eija Hämäläinen, Thomas F Hansen, Aster VE Harder, Heidi Hautakangas, Marjo Hiekkala, Maria G Hrafnsdottir, M. Arfan Ikram, Marjo-Riitta Järvelin, Risto Kajanne, Mikko Kallela, Jaakko Kaprio, Mari Kaunisto, Lisette JA Kogelman, Espen S Kristoffersen, Christian Kubisch, Mitja Kurki, Tobias Kurth, Lenore Launer, Terho Lehtimäki, Davor Lessel, Lannie Ligthart, Sigurdur H Magnusson, Rainer Malik, Bertram Müller-Myhsok, Carrie Northover, Dale R Nyholt, Jes Olesen, Aarno Palotie, Priit Palta, Linda M Pedersen, Nancy Pedersen, Matti Pirinen, Danielle Posthuma, Patricia Pozo-Rosich, Alice Pressman, Olli Raitakari, Caroline Ran, Gudrun R Sigurdardottir, Hreinn Stefansson, Kari Stefansson, Olafur A Sveinsson, Gisela M Terwindt, Thorgeir E Thorgeirsson, Arn MJM vanden Maagdenberg, Cornelia van Duijn, Maija Wessman, Bendik S Winsvold, John-Anker Zwart.
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
BackgroundMigraine has an increased prevalence in several immune disorders, but genetic cause-effect relationships remain unclear. Mendelian randomization (MR) was used in this study to explore whether immune diseases are causally associated with mig
Externí odkaz:
https://doaj.org/article/a30f6c7b567e43149a0c5afd66373445
Autor:
Thao Van Cao, Heidi G. Sutherland, Miles C. Benton, Larisa M. Haupt, Rodney A. Lea, Lyn R. Griffiths
Publikováno v:
Current Issues in Molecular Biology, Vol 45, Iss 10, Pp 7862-7877 (2023)
DNA methylation is an epigenetic factor that is modifiable and can change over a lifespan. While many studies have identified methylation sites (CpGs) related to aging, the relationship of these to gene function and age-related disease phenotypes rem
Externí odkaz:
https://doaj.org/article/c9b7b0d5fcc64bf8be5e79ac39f86a84
Autor:
Shanie Landen, Macsue Jacques, Danielle Hiam, Javier Alvarez-Romero, Ralf B. Schittenhelm, Anup D. Shah, Cheng Huang, Joel R. Steele, Nicholas R. Harvey, Larisa M. Haupt, Lyn R. Griffiths, Kevin J. Ashton, Séverine Lamon, Sarah Voisin, Nir Eynon
Publikováno v:
Biology of Sex Differences, Vol 14, Iss 1, Pp 1-20 (2023)
Abstract Background Exercise training elicits changes in muscle physiology, epigenomics, transcriptomics, and proteomics, with males and females exhibiting differing physiological responses to exercise training. However, the molecular mechanisms cont
Externí odkaz:
https://doaj.org/article/9cfe2efed4024313a006a9534e7ee91d
Autor:
Danit G. Saks, Beata Bajorek, Vibeke S. Catts, Adam C. Bentvelzen, Jiyang Jiang, Wei Wen, Karen A. Mather, Anbupalam Thalamuthu, Jessie Huang-Lung, Lisa Nivison-Smith, Lyn R. Griffiths, Robert A. Smith, Adrienne Sexton, Paul James, Tharusha Jayasena, Anne Poljak, Gurpreet K. Hansra, Satoshi Hosoki, Ashley Park, Claudia M. Hillenbrand, Peter van Wijngaarden, Russell J. Chander, Sam Humphrey, Rory Chen, Nicole A. Kochan, Tessa J. Helman, Christopher Levi, Amy Brodtmann, Michael J. O'Sullivan, Romesh Markus, Ken Butcher, Mark Parsons, Jason C. Kovacic, Perminder S. Sachdev
Publikováno v:
Cerebral Circulation - Cognition and Behavior, Vol 6, Iss , Pp 100225- (2024)
Introduction: Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy (CADASIL) is a rare genetic condition with a broad phenotypic presentation. This study aims to establish the first Australian cohort of individua
Externí odkaz:
https://doaj.org/article/526edede2535460a845731b93a501cc1
Autor:
Deniz Ozberk, Alison Haywood, Heidi G. Sutherland, Chieh Yu, Cassie L. Albury, Mathew Zunk, Rani George, Phillip Good, Lyn R. Griffiths, Janet Hardy, Larisa M. Haupt
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-7 (2022)
Abstract Opioids are the therapeutic agents of choice to manage moderate to severe pain in patients with advanced cancer, however the unpredictable inter-individual response to opioid therapy remains a challenge for clinicians. While studies are few,
Externí odkaz:
https://doaj.org/article/bf9bdce28ad74f1da1d63fcf9f426c15
Publikováno v:
Data in Brief, Vol 46, Iss , Pp 108880- (2023)
To obtain this dataset, two human HER2-positive breast cancer cell lines (SKBR3 and MDA-MB-453 cell lines) were cultured in basal growth media to 80% confluence. Cells were passaged and total RNA extracted, RNA converted to cDNA and diluted to a work
Externí odkaz:
https://doaj.org/article/1592aba1995f4dc19fc44ec584a4b3e5
Autor:
Ngan K. Tran, Rodney A. Lea, Samuel Holland, Quan Nguyen, Arti M. Raghubar, Heidi G. Sutherland, Miles C. Benton, Larisa M. Haupt, Nicholas B. Blackburn, Joanne E. Curran, John Blangero, Andrew J. Mallett, Lyn R. Griffiths
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
Abstract Chronic kidney disease (CKD) is a persistent impairment of kidney function. Genome-wide association studies (GWAS) have revealed multiple genetic loci associated with CKD susceptibility but the complete genetic basis is not yet clear. Since
Externí odkaz:
https://doaj.org/article/08009bcdb0694bb7ba1a1392cc5bb0b2