Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Lyn M Powell"'
Autor:
Jason R Chan, Gregory Vuillaume, Caitlin Bever, Stefan Lebrun, Michael Lietz, Yvonne Steffen, Katrin Stolle, Karim Wahba, Xiao Wang, Shonna Moodie, Julia Hoeng, Manuel C Peitsch, Lyn M Powell
Publikováno v:
BioDiscovery, Vol 3, Iss , Pp 1-13 (2012)
Motivation:Atherosclerosis is a complex multi-pathway inflammatory disease where accumulation of oxidatively modified lipids and leukocytes in the arterial intima leads to plaque formation over time. Translating Apoe-/- mouse results to the clinical
Externí odkaz:
https://doaj.org/article/e87ffa701b074622a23a688c4c0f1401
Autor:
Masood Khaksar Toroghi, Jim Bosley, Lyn M. Powell, Yi Zhang, Feng Yang, Xia Pu, John D. Davis, Nidal Al‐Huniti
Publikováno v:
CPT: Pharmacometrics & Systems Pharmacology, Vol 10, Iss 11, Pp 1332-1342 (2021)
Abstract A model to quantitatively characterize the effect of evinacumab, an investigational monoclonal antibody against angiopoietin‐like protein 3 (ANGPTL3) on lipid trafficking is needed. A quantitative systems pharmacology (QSP) approach was de
Externí odkaz:
https://doaj.org/article/f2c85718b9bd447bb1c865f81dfe8b6c
Autor:
Nidal Al-Huniti, Lyn M Powell, Jim Bosley, Masood Khaksar Toroghi, Feng Yang, Xia Pu, John D. Davis, Yi Zhang
Publikováno v:
CPT: Pharmacometrics & Systems Pharmacology, Vol 10, Iss 11, Pp 1332-1342 (2021)
CPT: Pharmacometrics & Systems Pharmacology
CPT: Pharmacometrics & Systems Pharmacology
A model to quantitatively characterize the effect of evinacumab, an investigational monoclonal antibody against angiopoietin‐like protein 3 (ANGPTL3) on lipid trafficking is needed. A quantitative systems pharmacology (QSP) approach was developed t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::95276fb9037f0e08c28e3388a44bc95a
https://doaj.org/article/f2c85718b9bd447bb1c865f81dfe8b6c
https://doaj.org/article/f2c85718b9bd447bb1c865f81dfe8b6c
Autor:
Lyn M Powell, Caitlin A. Bever, Gregory Vuillaume, Julia Hoeng, Shonna Moodie, Yvonne Steffen, Xiao Wang, Jason R Chan, Katrin Stolle, Stefan Lebrun, Michael Lietz, Manuel C. Peitsch, Karim Wahba
Publikováno v:
BioDiscovery, Vol 3, Iss, Pp 1-13 (2012)
BioDiscovery 3: e8929
BioDiscovery 3: e8929
Motivation:Atherosclerosis is a complex multi-pathway inflammatory disease where accumulation of oxidatively modified lipids and leukocytes in the arterial intima leads to plaque formation over time. Translating Apoe-/- mouse results to the clinical
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c2ff3ede87bab7f6826e6cb277e85292
https://doi.org/10.7750/biodiscovery.2012.3.2
https://doi.org/10.7750/biodiscovery.2012.3.2
Publikováno v:
Journal of Clinical Investigation. 87:767-771
Elevated plasma levels of lipoprotein(a), Lp(a), represent a major, inherited risk factor for coronary heart disease, although the mechanism of its action remains unknown. Lp(a) is distinguished from the related LDL particle by the addition of apolip
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::beb6d1de9cb2ae1a6199e22aca2d95e8
https://doi.org/10.1172/jci115079
https://doi.org/10.1172/jci115079
Publikováno v:
FEMS Microbiology Letters. 12:61-64
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::af2e91a719eac3ee11f201571a8b31bf
https://doi.org/10.1111/j.1574-6968.1981.tb07612.x
https://doi.org/10.1111/j.1574-6968.1981.tb07612.x
Autor:
Timothy J. Knott, Stanley C. Rall, Thomas L. Innerarity, Shellie F. Jacobson, Mickey S. Urdea, Beatriz Levy-Wilson, Lyn M. Powell, Richard J. Pease, Roger Eddy, Hiroshi Nakai, Mary Byers, Linda M. Priestley, Elaine Robertson, Leslie B. Rall, Christer Betsholtz, Thomas B. Shows, Robert W. Mahley, James Scott
Publikováno v:
Science. 230:37-43
Apolipoprotein (apo-) B is the ligand responsible for the receptor-mediated catabolism of low density lipoproteins, the principal cholesterol-transporting lipoproteins in plasma. The primary structure of the carboxyl-terminal 30 percent (1455 amino a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::76c4938d1102c0fac97cebe7eae0f68b
https://doi.org/10.1126/science.2994225
https://doi.org/10.1126/science.2994225
Publikováno v:
Moleculargeneral genetics : MGG. 206(1)
The oligopeptide permease is encoded by at least four genes which are transcribed as a single operon. We cloned and characterized this operon from Salmonella typhimurium, as well as the flanking genes, tonB, ana and a new gene, cwd, which affects cel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01fc189c55c928c1da5f6e0fee054647
https://pubmed.ncbi.nlm.nih.gov/3033433
https://pubmed.ncbi.nlm.nih.gov/3033433
Publikováno v:
Biochemical Society Transactions. 9:248P-248P
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ba129cbefb91b6ac515c4855c279f93e
https://doi.org/10.1042/bst009248pd
https://doi.org/10.1042/bst009248pd