Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Lyn'Al Nosaka"'
Autor:
Luise Westernberg, Claire Conche, Yina Hsing Huang, Stephanie Rigaud, Yisong Deng, Sabine Siegemund, Sayak Mukherjee, Lyn'Al Nosaka, Jayajit Das, Karsten Sauer
Publikováno v:
eLife, Vol 5 (2016)
β-selection is the most pivotal event determining αβ T cell fate. Here, surface-expression of a pre-T cell receptor (pre-TCR) induces thymocyte metabolic activation, proliferation, survival and differentiation. Besides the pre-TCR, β-selection al
Externí odkaz:
https://doaj.org/article/1ae57ac0454547c3a658659fd48d389b
Autor:
Alexander L. Ruchelman, Jack Houston, Nai-Yu Wang, Lyn'Al Nosaka, Antonia Lopez-Girona, Takumi Ito, Gilles Carmel, Mary E Matyskiela, Wei Fang, Derek Nguyen, Philip P Chamberlain, Thomas O. Daniel, Karen Miller, Chin-Chun Lu, Barbra Pagarigan, Svetlana Gaidarova, Gang Lu, Shuichan Xu, James Carmichael, Tam Tran, Gabriel C. Lander, Mariko Riley, Brian E. Cathers, Hiroshi Handa
Publikováno v:
Nature. 535:252-257
Immunomodulatory drugs bind to cereblon (CRBN) to confer differentiated substrate specificity on the CRL4(CRBN) E3 ubiquitin ligase. Here we report the identification of a new cereblon modulator, CC-885, with potent anti-tumour activity. The anti-tum
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::91e627c880e58840f87057e76f90aa5d
https://doi.org/10.1038/nature18611
https://doi.org/10.1038/nature18611
Autor:
Sabine Siegemund, Stephanie Rigaud, Yisong Deng, Lyn'Al Nosaka, Sayak Mukherjee, Luise Westernberg, Yina H. Huang, Claire Conche, Karsten Sauer, Jayajit Das
Publikováno v:
eLife
eLife, Vol 5 (2016)
eLife, Vol 5 (2016)
β-selection is the most pivotal event determining αβ T cell fate. Here, surface-expression of a pre-T cell receptor (pre-TCR) induces thymocyte metabolic activation, proliferation, survival and differentiation. Besides the pre-TCR, β-selection al
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4abed79c9132e8506708e9315eca7188
http://europepmc.org/articles/PMC4764578
http://europepmc.org/articles/PMC4764578
Autor:
Ryan N. Jackson, Blake Wiedenheft, MaryClare F. Rollins, Joshua Carter, Gabriel C. Lander, Saikat Chowdhury, Lyn‘Al Nosaka
Publikováno v:
Biophysical Journal. 112:334a-335a
Bacteria and archaea have evolved different CRISPR based adaptive immune system for defense against phage infections. Pseudomonas aeruginosa has type I-F CRISPR-cas defense system, where the cas-crRNA surveillance complex (csy-complex) binds to forei
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e6ffa1927c385dd810e9a1c6f450c099
https://doi.org/10.1016/j.bpj.2016.11.1811
https://doi.org/10.1016/j.bpj.2016.11.1811
Autor:
Tam Tran, Gabriel C. Lander, James Carmichale, Thomas O. Daniel, Svetlana Gaidarova, Mary E Matyskiela, Lyn'Al Nosaka, Antonia Lopez-Girona, Takumi Ito, Alexander L. Ruchelman, Gilles Carmel, Jack Houston, Brian E. Cathers, Philip P Chamberlain, Wei Fang, Hiroshi Handa, Derek Nguyen, Mariko Riley, Karen Miller, Shuichan Xu, Barbra Pagarigan, Gang Lu, Chin-Chu Lu, Nai-Yu Wang
Publikováno v:
Cancer Research. 77:SY37-02
The protein cereblon is part of the CRL4-CRBN E3 ubiquitin ligase complex, and has been shown to be the molecular target for the drugs lenalidomide and pomalidomide. These drugs bind to the surface of cereblon, triggering the recruitment of substrate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2acec69e19aebcc0985034bd9ab2603b
https://doi.org/10.1158/1538-7445.am2017-sy37-02
https://doi.org/10.1158/1538-7445.am2017-sy37-02
Autor:
Lyn'Al Nosaka, Karen L. Maxwell, Joshua Carter, MaryClare F. Rollins, Sarah Golden, Elizabeth R. Fischer, Joseph Bondy-Denomy, Connor Hoffmann, Gabriel C. Lander, Alan R. Davidson, Saikat Chowdhury, Ryan N. Jackson, Blake Wiedenheft
Publikováno v:
Cell, vol 169, iss 1
Genetic conflict between viruses and their hosts drives evolution and genetic innovation. Prokaryotes evolved CRISPR (Clustered Regularly Interspaced Short Palindromic Repeat)-mediated adaptive immune systems for protection from viral infection and v
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5223b8be438416deb62aee0cee15efd3
https://doi.org/10.1016/j.cell.2017.03.012
https://doi.org/10.1016/j.cell.2017.03.012
Autor:
Claire Conche, Luise Westernberg, Yina Huang, Stephanie Rigaud, Sabine Siegemund, Sayak Mukherjee, Lyn'Al Nosaka, Jayajit Das, Karsten Sauer
Publikováno v:
The Journal of Immunology. 194:51.11-51.11
In β-selection, surface-expression of a pre-T cell receptor (pre-TCR) induces thymocyte metabolic activation, proliferation, survival and differentiation. This pivotal αβ T cell fate-determining event requires co-stimulatory Notch signals. Here, w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::db47130bd21b1b0e675a4f69a074f697
https://doi.org/10.4049/jimmunol.194.supp.51.11
https://doi.org/10.4049/jimmunol.194.supp.51.11
Autor:
Karsten Sauer, Yina Huang, Stephanie Rigaud, Claire Conche, Lyn'Al Nosaka, Sabine Siegemund, Luise Sternberg
Publikováno v:
The Journal of Immunology. 192:116.3-116.3
In β-selection, surface-expression of a pre-T cell receptor (pre-TCR) induces thymocyte metabolic activation, proliferation, survival and differentiation. This pivotal αβ T cell fate-determining event requires co-stimulatory Notch signals. Here, w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::398c178d4efc9ee7342c0d05ed563453
https://doi.org/10.4049/jimmunol.192.supp.116.3
https://doi.org/10.4049/jimmunol.192.supp.116.3
Publikováno v:
Biophysical Journal. (8):1663-1675
Viral terminase enzymes serve as genome packaging motors in many complex double-stranded DNA viruses. The functional motors are multiprotein complexes that translocate viral DNA into a capsid shell, powered by a packaging ATPase, and are among the mo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::710fff07cdfd7cad79f05be4b753a97a