CD3e-immunotoxin spares CD62Llo Tregs and reshapes organ-specific T-cell composition by preferentially depleting CD3ehi T cells

Autor: Shihyoung Kim, Rajni Kant Shukla, Hannah Yu, Alice Baek, Sophie G. Cressman, Sarah Golconda, Ga-Eun Lee, Hyewon Choi, John C. Reneau, Zhirui Wang, Christene A. Huang, Namal P. M. Liyanage, Sanggu Kim

Publikováno v: Frontiers in Immunology, Vol 13 (2022)

CD3-epsilon(CD3e) immunotoxins (IT), a promising precision reagent for various clinical conditions requiring effective depletion of T cells, often shows limited treatment efficacy for largely unknown reasons. Tissue-resident T cells that persist in p

Externí odkaz: https://doaj.org/article/3b840e0ad0204180b5823337e4db9f75

Expanding the armory for treating lymphoma: Targeting redox cellular status through thioredoxin reductase inhibition

Autor: Sicong Wang, Giovanna Di Trapani, Kathryn F. Tonissen

Publikováno v: Pharmacological Research, Vol 177, Iss , Pp 106134- (2022)

Lymphoma refers to a group of cancers that arise from lymphocytes and is the most common form of hematological malignancy in adults. While the recent availability of specific chemotherapy regimes has resulted in good patient outcomes for some lymphom

Externí odkaz: https://doaj.org/article/9086160436cc4472a42a6b668542ea66

The role of 18F-FDG PET/CT in evaluation of therapy effectiveness and prognosis of lymphomas

Autor: N. G. Chanchikova, V. I. Chernov, E. A. Dudnikova, E. A. Karlova, A. S. Savelyeva, O. A. Silkina, R. V. Zelchan, O. D. Bragin, A. A. Medvedeva, E. V. Berezneeva

Publikováno v: Bûlleten' Sibirskoj Mediciny, Vol 20, Iss 2, Pp 120-129 (2021)

Aim. To determine the diagnostic value of positron emission tomography (PET)/computed tomography (CT) with F-18 fluorodeoxyglucose (18F-FDG) for monitoring the effectiveness and prognosis of lymphoma therapy.Materials and methods. Retrospective data

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doajarticles::18df2f70a6b78cb1110c865c05d42355
https://bulletin.tomsk.ru/jour/article/view/4388

Total Body Irradiation or Chemotherapy Conditioning in Childhood ALL: A Multinational, Randomized, Noninferiority Phase III Study

Autor: Peters, Christina, Dalle, Jean-Hugues, Locatelli, Franco, Poetschger, Ulrike, Sedlacek, Petr, Buechner, Jochen, Shaw, Peter J, Staciuk, Raquel, Ifversen, Marianne, Pichler, Herbert, Vettenranta, Kim, Svec, Peter, Aleinikova, Olga, Stein, Jerry, Güngör, Tayfun, Toporski, Jacek, Truong, Tony H, Diaz-de-Heredia, Cristina, Bierings, Marc, Ariffin, Hany, Essa, Mohammed, Burkhardt, Birgit, Schultz, Kirk, Meisel, Roland, Lankester, Arjan, Ansari Djaberi, Marc Georges, Schrappe, Martin, von Stackelberg, Arend, Balduzzi, Adriana, Corbacioglu, Selim, Bader, Peter, IBFM Study Group, IntReALL Study Group, I-BFM SCT Study Group, EBMT Paediatric Diseases Working Party

Publikováno v: Journal of clinical oncology, Vol. 39, No 4 (2021) pp. 295-307
Journal of Clinical Oncology
Journal of Clinical Oncology, 39(4), 295-308. LIPPINCOTT WILLIAMS & WILKINS
Strahlentherapie Und Onkologie

PURPOSE Total body irradiation (TBI) before allogeneic hematopoietic stem cell transplantation (HSCT) in pediatric patients with acute lymphoblastic leukemia (ALL) is efficacious, but long-term side effects are concerning. We investigated whether pre

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c31dae55370a44311a402016446c585
https://doi.org/10.1200/jco.20.02529

SYSTEMIC FRONT LINE THERAPY OF FOLLICULAR LYMPHOMA: WHEN, TO WHOM AND HOW

Autor: Francesca Pavanello, Sara Steffanoni, Michele Ghielmini, Emanuele Zucca

Publikováno v: Mediterranean Journal of Hematology and Infectious Diseases, Vol 8, Iss 0, Pp e2016062-e2016062 (2016)

The natural history of follicular lymphoma is usually characterized by an indolent course with a high response rate to the first line therapy followed by recurrent relapses, with a time to next treatment becoming shorter after each subsequent treatme

Externí odkaz: https://doaj.org/article/732860f82c7e4ee78973c62b54825d6b