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The underestimated posterior lymphatic drainage of the prostate: An historical overview and preliminary anatomical study on cadaver

Autor: Raffaele De Caro, Carla Stecco, Antonio Benito Porcaro, Michał Polguj, Rafael Boscolo-Berto, Veronica Macchi, Andrea Porzionato, Salvatore Siracusano

Publikováno v: The Prostate. 80:153-161

Background The evidence of pelvic lymph node metastases after radical prostatectomy (RP) with pelvic lymph node dissection (PLND) is one of the strongest prognostic factors for poor oncologic outcome. The extent of PLND, although representing a cruci

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4efd5fcca66d0111b0a0e7222e7239b2
https://doi.org/10.1002/pros.23927

Unique functions for Notch4 in murine embryonic lymphangiogenesis

Autor: Bhairavi Swaminathan, Joseph D McCarron, Ajit Muley, Gloria Riitano, Carrie J. Shawber, Minji Kim Uh, Jennifer M. James, Jan Kitajewski, Glicella Salazar-De Simone, Chris Kitajewski, Maria Gnarra Buethe, Yoh-suke Mukoyama, Seock Won Youn, Aino Murtomaki

In mice, embryonic dermal lymphatic development is well-understood and used to study gene functions in lymphangiogenesis. Notch signaling is an evolutionarily conserved pathway that modulates cell fate decisions, which has been shown to both inhibit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::606d651e1f4d56620ab1e08c9e437803
https://doi.org/10.1101/2021.02.19.431982

Polydom Is an Extracellular Matrix Protein Involved in Lymphatic Vessel Remodeling

Autor: Itsuko Nakano, Naoki Mochizuki, Hiroyuki Nakajima, Ryoko Sato-Nishiuchi, Chisei Shimono, Yuta Totani, Sugiko Futaki, Kiyotoshi Sekiguchi, Masafumi Nishino, Nanami Morooka

Publikováno v: Circulation Research. 120:1276-1288

Rationale: Lymphatic vasculature constitutes a second vascular system essential for immune surveillance and tissue fluid homeostasis. Maturation of the hierarchical vascular structure, with a highly branched network of capillaries and ducts, is cruci

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::58f89215fe5741c1b49365423c09673a
https://doi.org/10.1161/circresaha.116.308825

Regulation of lymphangiogenesis in the diaphragm by macrophages and VEGFR-3 signaling

Autor: Steven T. Proulx, Alexandra M. Ochsenbein, Athanasia Dasargyri, Jyothi Chittazhathu, E. Richard Stanley, Chloé Chong, Michael Detmar, Jean-Christophe Leroux, Sinem Karaman, Rhea Goldmann

Publikováno v: Angiogenesis
Ochsenbein, Alexandra M; Karaman, Sinem; Proulx, Steven T; Goldmann, Rhea; Chittazhathu, Jyothi; Dasargyri, Athanasia; Chong, Chloé; Leroux, Jean-Christophe; Stanley, E Richard; Detmar, Michael (2016). Regulation of lymphangiogenesis in the diaphragm by macrophages and VEGFR-3 signaling. Angiogenesis, 19(4), pp. 513-524. Springer Netherlands 10.1007/s10456-016-9523-8

Lymphatic vessels play important roles in fluid drainage and in immune responses, as well as in pathological processes including cancer progression and inflammation. While the molecular regulation of the earliest lymphatic vessel differentiation and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bbab56949dfbb7b468189b4757251532
http://europepmc.org/articles/PMC5026726