Successful Treatment of Pembrolizumab-Induced Severe Capillary Leak Syndrome and Lymphatic Capillary Dysfunction

Autor: Nelson Leung, Sandra M. Herrmann, Svetomir N. Markovic, Itunu Owoyemi, Brittany Vlaminck, Haixia Qin

Publikováno v: Mayo Clinic Proceedings: Innovations, Quality & Outcomes, Vol 5, Iss 3, Pp 670-674 (2021)
Mayo Clinic Proceedings: Innovations, Quality & Outcomes

Although capillary leak syndrome has a high mortality rate, its trigger, diagnosis, and treatment remain a challenge to clinicians because of the poor understanding of its mechanism and lack of treatment guidelines. With the extended use of immune ch

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::977be9396fe111ba964f0f3838fc182e
http://www.sciencedirect.com/science/article/pii/S2542454821000047

Effects of HLEC on the secreted proteins of epithelial ovarian cancer cells prone to metastasize to lymph nodes

Autor: Xin-Ying Zhang, Fu-Qiang Yin, Li Liu, Ting Gao, He-Yun Ruan, Xiao Guan, Ying-Xin Lu, Dan-Rong Li

Publikováno v: Cancer Biology & Medicine, Vol 10, Iss 4, Pp 221-226 (2013)

Objective:To study explores the effect of HLEC on the secreted proteins of epithelial ovarian cancer (EOC) cells (SKOV3-PM4) with directional highly lymphatic metastasis.Methods:Supernatants of four groups of cultured cells, namely, SKOV3 (A), SKOV3+

Externí odkaz: https://doaj.org/article/8c207edae2894c8da1dd6d6c4bfd6d5d

Infection-Induced Dermal Lymphatic Zippering Restricts Viral Dissemination from Skin and Promotes Anti-Viral CD8+ T Cell Expansion

Autor: H. du Bois, M. M. Steele, T. A. Heim, J. C. Nolz, T. Mudianto, Madeline J Churchill, Amanda W. Lund

Lymphatic vessels are often considered passive conduits that rapidly flush antigenic material, pathogens, and cells to draining lymph nodes. Recent evidence, however, suggests that lymphatic vessels actively regulate diverse processes from antigen tr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7649a379e77e0feb42017facd92ff8f8
https://doi.org/10.1101/2021.08.26.457551

Long-Distance Tracing of the Lymphatic System with a Computed Tomography/Fluorescence Dual-Modality Nanoprobe for Surveying Tumor Lymphatic Metastasis

Autor: Qingming Luo, Sha Qiao, Yuan Qian, Liujuan Wu, Lisen Lu, Zhihong Zhang, Dong-Mei Yan, Guoqiang Xu, Hao Zheng, Xiaoquan Yang

Publikováno v: Bioconjugate Chemistry. 30:1199-1209

Noninvasive visualization of deep tissue lymphatic metastasis is crucial for diagnosing malignant tumors and predicting prognosis. However, the limited diffusivity and specificity of imaging contrast agents that are transported in lymph vessels (LVs)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9cd56b825bd96a1956ec8024d9379075
https://doi.org/10.1021/acs.bioconjchem.9b00144

Dichotomous effects on lymphatic transport with loss of caveolae in mice

Autor: Heidi A. Creed, Suman S. Vadlamani, Walter E. Cromer, Andrea J. Reyna, Wei Wang, Ranjeet M. Dongaonkar, Bradley D. Upchurch, David C. Zawieja, Napoleon C. Busbuso, Mary-Catherine C. Clark, Matt C. Smithhart, Joseph M. Rutkowski, Stephanie N. Blais, Gaurav Baranwal

Publikováno v: Acta physiologica (Oxford, England). 232(4)

AIM Fluid and macromolecule transport from the interstitium into and through lymphatic vessels is necessary for tissue homeostasis. While lymphatic capillary structure suggests that passive, paracellular transport would be the predominant route of ma

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f8973056a4db79f3daf531a4ff7e1f74
https://pubmed.ncbi.nlm.nih.gov/34057826