Zobrazeno 1 - 10
of 161
pro vyhledávání: '"Lymph node-targeting"'
Autor:
Wei Zheng, Shixiong Li, Zhongliang Shi, Kailing Su, Yu Ding, Luyue Zhang, Qian Tang, Jiani Han, Han Zhao, Fengwei Wang, Hongru Zhang, Zhangyong Hong
Publikováno v:
Journal of Nanobiotechnology, Vol 22, Iss 1, Pp 1-20 (2024)
Abstract Background Tumor neoantigen peptide-based vaccines, systemic immunotherapies that enhance antitumor immunity by activating and expanding antigen-specific T cells, have achieved remarkable results in the treatment of a variety of solid tumors
Externí odkaz:
https://doaj.org/article/04cf4040c0c94dfba603e03929951722
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 14, Iss 9, Pp 4102-4117 (2024)
Tumor vaccine, a promising modality of tumor immunotherapy, needs to go through the process of tumor antigen generation and loading, antigen drainage to lymph nodes (LNs), antigen internalization by dendritic cells (DCs), DC maturation, and antigen c
Externí odkaz:
https://doaj.org/article/61bcdf2b95ba4d0aa73d5c9f523d4fc0
Autor:
Erin M. Euliano, Anushka Agrawal, Marina H. Yu, Tyler P. Graf, Emily M. Henrich, Alyssa A. Kunkel, Chia‐Chien Hsu, Tsvetelina Baryakova, Kevin J. McHugh
Publikováno v:
Bioengineering & Translational Medicine, Vol 9, Iss 6, Pp n/a-n/a (2024)
Abstract Lymph node (LN)‐resident dendritic cells (DCs) are a promising target for vaccination given their professional antigen‐presenting capabilities and proximity to a high concentration of immune cells. Direct intra‐LN injection has been sh
Externí odkaz:
https://doaj.org/article/d3736a03bc784763b5a924a500f74319
Publikováno v:
Journal of Nanobiotechnology, Vol 22, Iss 1, Pp 1-17 (2024)
Abstract Tumor vaccines, a crucial immunotherapy, have gained growing interest because of their unique capability to initiate precise anti-tumor immune responses and establish enduring immune memory. Injected tumor vaccines passively diffuse to the a
Externí odkaz:
https://doaj.org/article/60a0edcddd614e6d98ae1144185c4908
Autor:
Lei Zhou, Ling Zhao, Mengyao Wang, Xu Qi, Xin Zhang, Qingying Song, Dayu Xue, Meihua Mao, Zhenzhong Zhang, Jinjin Shi, Pilei Si, Junjie Liu
Publikováno v:
Advanced Science, Vol 11, Iss 33, Pp n/a-n/a (2024)
Abstract Therapeutic cancer vaccines are among the first FDA‐approved cancer immunotherapies. Among them, it remains a major challenge to achieve robust lymph‐node (LN) accumulation. However, delivering cargo into LN is difficult owing to the uni
Externí odkaz:
https://doaj.org/article/685a70e8c37f4c40ad5bc7b67ab69894
Autor:
Guo, Wen a, Zhang, Xinyue a, Wan, Long b, c, Wang, Zhiqi a, Han, Meiqi d, Yan, Ziwei a, Li, Jia a, Deng, Ruizhu a, Li, Shenglong e, Mao, Yuling a, ∗∗, Wang, Siling a, ∗
Publikováno v:
In Journal of Pharmaceutical Analysis December 2024 14(12)
Autor:
Jie Wang, Zongying Zhang, Rongxiang Liang, Wujun Chen, Qian Li, Jiazhen Xu, Hongmei Zhao, Dongming Xing
Publikováno v:
Materials Today Bio, Vol 26, Iss , Pp 101068- (2024)
Lymph nodes (LNs) occupy a critical position in initiating and augmenting immune responses, both spatially and functionally. In cancer immunotherapy, tumor-specific vaccines are blooming as a powerful tool to suppress the growth of existing tumors, a
Externí odkaz:
https://doaj.org/article/3ef17f9de0294eb28e8bc69462a584a2
Autor:
Yu Xiang, Miaomiao Tian, Juan Huang, Yueyi Li, Guangqi Li, Xue Li, Zedong Jiang, Xiangrong Song, Xuelei Ma
Publikováno v:
Journal of Nanobiotechnology, Vol 21, Iss 1, Pp 1-10 (2023)
Abstract Background Targeting EBV-proteins with mRNA vaccines is a promising way to treat EBV-related tumors like nasopharyngeal carcinoma (NPC). We assume that it may sensitize tumors to immune checkpoint inhibitors. Results We developed an LMP2-mRN
Externí odkaz:
https://doaj.org/article/59e359b18cd24f2b9aa64b0b2d5e0d7a
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 13, Iss 8, Pp 3321-3338 (2023)
Designing and manufacturing safe and effective vaccines is a crucial challenge for human health worldwide. Research on adjuvant-based subunit vaccines is increasingly being explored to meet clinical needs. Nevertheless, the adaptive immune responses
Externí odkaz:
https://doaj.org/article/a9c1063d7b924300b936c6f233bdd899
Autor:
Jiawu Wan, Zongmei Wang, Lingli Wang, Liqin Wu, Chengguang Zhang, Ming Zhou, Zhen F. Fu, Ling Zhao
Publikováno v:
mBio, Vol 15, Iss 1 (2024)
ABSTRACTSeveral recent attempts to improve the stability and immunogenicity of messenger RNA (mRNA) vaccines include the use of circular RNA (circRNA), targeted delivery, and lyophilization. However, these research directions have often been pursued
Externí odkaz:
https://doaj.org/article/65fafdd76aa8429da1d2c830d6052ebf