Lymphocyte Circadian Clocks Control Lymph Node Trafficking and Adaptive Immune Responses

Autor: Rainer Haas, Hanspeter Herzel, Werner Solbach, Leif E. Sander, Louise Ince, Marc Ehlers, Kerstin Kraus, Olaf Uhl, Ute Harrison, Anthony H. Tsang, David Druzd, Wenyan He, Alexei Leliavski, Berthold Koletzko, Christoph Scheiermann, Naoto Kawakami, Alba de Juan, Olga Matveeva, Henrik Oster, Christoph Schmal, Chien-Sin Chen, Ling Yao, Sophia Martina Hergenhan

Publikováno v: Immunity, Vol. 46, No 1 (2017) pp. 120-132
Immunity

Lymphocytes circulate through lymph nodes (LN) in search for antigen in what is believed to be a continuous process. Here, we show that lymphocyte migration through lymph nodes and lymph occurred in a non-continuous, circadian manner. Lymphocyte homi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9fbbdc6c7546659b41bd5d291fa0964e

Lymph node migratory dendritic cells modulate HIV-1 transcription through PD-1 engagement

Autor: Riddhima Banga, Khalid Ohmiti, Matthieu Perreau, Kalliopi Ioannidou, Laurence de Leval, Francesco A. Procopio, Caterina Rebecchini, Alessandra Noto, Matthias Cavassini, Olivia Munoz, Giuseppe Pantaleo, Craig Fenwick, Jean-Marc Corpataux

Publikováno v: PLoS pathogens, vol. 15, no. 7, pp. e1007918
PLoS Pathogens, Vol 15, Iss 7, p e1007918 (2019)
PLoS Pathogens

T-follicular helper (Tfh) cells, co-expressing PD-1 and TIGIT, serve as a major cell reservoir for HIV-1 and are responsible for active and persistent HIV-1 transcription after prolonged antiretroviral therapy (ART). However, the precise mechanisms r

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a75d9b74797de056653603fd5facae8
https://serval.unil.ch/resource/serval:BIB_1FF4BBBC8958.P001/REF.pdf

Inflammatory Mediators in the Mesenteric Lymph Nodes, Site of a Possible Intermediate Phase in the Immune Response to Feline Coronavirus and the Pathogenesis of Feline Infectious Peritonitis?

Autor: Marina L. Meli, Alexandra Malbon, Andrew D. Davidson, Séverine Tasker, Anja Kipar, Emi N Barker

Publikováno v: Malbon, A J, Meli, M L, Barker, E N, Davidson, A D, Tasker, S & Kipar, A 2019, ' Inflammatory Mediators in the Mesenteric Lymph Nodes, Site of a Possible Intermediate Phase in the Immune Response to Feline Coronavirus and the Pathogenesis of Feline Infectious Peritonitis? ', Journal of Comparative Pathology, vol. 166, pp. 69-86 . https://doi.org/10.1016/j.jcpa.2018.11.001
JOURNAL OF COMPARATIVE PATHOLOGY
Malbon, A J, Meli, M L, Barker, E N, Davidson, A D, Tasker, S & Kipar, A 2018, ' Inflammatory Mediators in the Mesenteric Lymph Nodes, Site of a Possible Intermediate Phase in the Immune Response to Feline Coronavirus and the Pathogenesis of Feline Infectious Peritonitis? ', Journal of Comparative Pathology, vol. 166, pp. 69-86 . https://doi.org/10.1016/j.jcpa.2018.11.001
Journal of Comparative Pathology

Summary Feline infectious peritonitis (FIP) is an almost invariably fatal feline coronavirus (FCoV)-induced disease thought to arise from a combination of viral mutations and an overexuberant immune response. Natural initial enteric FCoV infection ma

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff566a8586eb4a9dc066d81f88ea40c8
https://research-information.bris.ac.uk/en/publications/5da2da2d-12be-4c38-a929-918625f1308a

Attenuation of chronic antiviral T-cell responses through constitutive COX2-dependent prostanoid synthesis by lymph node fibroblasts

Autor: Karin Schaeuble, Stéphanie Favre, Dietmar Zehn, Daniel E. Speiser, Hélène Cannelle, Sanjiv A. Luther, Susanne Oberle, Hsin-Ying Huang

Publikováno v: PLoS Biology, Vol 17, Iss 7, p e3000072 (2019)
PLOS Biology
PLoS biology, vol. 17, no. 7, pp. e3000072
PLoS Biology

Lymphoid T-zone fibroblastic reticular cells (FRCs) actively promote T-cell trafficking, homeostasis, and expansion but can also attenuate excessive T-cell responses via inducible nitric oxide (NO) and constitutive prostanoid release. It remains uncl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d4806e8ec0fe2623baf2e627e52e086
https://mediatum.ub.tum.de/1545390

pMHC affinity controls duration of CD8+ T cell-DC interactions and imprints timing of effector differentiation versus expansion

Autor: Ozga, Aleksandra J, Moalli, Federica, Abe, Jun, Swoger, Jim, Sharpe, James, Zehn, Dietmar, Kreutzfeldt, Mario, Merkler, Doron, Ripoll, Jorge, Stein, Jens V, McKee, Trevor, Vellanki, Ravi, Chen, Eric, Bristow, Robert G, Wouters, Bradly G, Koritzinsky, Marianne

Publikováno v: Ozga, Aleksandra J; Moalli, Federica; Abe, Jun; Swoger, Jim; Sharpe, James; Zehn, Dietmar; Kreutzfeldt, Mario; Merkler, Doron; Ripoll, Jorge; Stein, Jens Volker (2016). pMHC affinity controls duration of CD8+ T cell-DC interactions and imprints timing of effector differentiation versus expansion. The Journal of experimental medicine, 213(12), pp. 2811-2829. Rockefeller Univ. Press 10.1084/jem.20160206
The Journal of experimental medicine, vol. 213, no. 12, pp. 2811-2829
The Journal of Experimental Medicine
e-Archivo. Repositorio Institucional de la Universidad Carlos III de Madrid
instname
Repositorio Institucional de la Consejería de Sanidad de la Comunidad de Madrid
Consejería de Sanidad de la Comunidad de Madrid
Journal of Experimental Medicine, Vol. 213, No 12 (2016) pp. 2811-2829
The Journal of experimental medicine

Ozga and colleagues use intravital two-photon microscopy and quantitative whole-organ imaging to reveal the dynamics of early affinity-driven CD8+ T cell activation.
During adaptive immune responses, CD8+ T cells with low TCR affinities are rele

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a19a2a1a46c82c65a6d46a1890dda94
https://boris.unibe.ch/95381/1/2811.full.pdf