Atom and step economical synthesis of acyclic quaternary centers via iridium-catalyzed hydroarylative cross-coupling of 1,1-disubstituted alkenes

Autor: Phillippa Cooper, Andrew G. Dalling, Elliot H. E. Farrar, Timothy P. Aldhous, Simon Grélaud, Eleanor Lester, Lyman J. Feron, Paul D. Kemmitt, Matthew N. Grayson, John F. Bower

Publikováno v: Cooper, P, Dalling, A G, Farrar, E H E, Aldhous, T P, Grélaud, S, Lester, E, Feron, L J, Kemmitt, P D, Grayson, M N & Bower, J F 2022, ' Atom and step economical synthesis of acyclic quaternary centers via iridium-catalyzed hydroarylative cross-coupling of 1,1-disubstituted alkenes ', Chemical Science, vol. 13, no. 37, pp. 11183-11189 . https://doi.org/10.1039/D2SC02790A

Quaternary benzylic centers are accessed with high atom and step economy by Ir-catalyzed alkene hydroarylation. These studies provide unique examples of the use of non-polarized 1,1-disubstituted alkenes in branch selective Murai-type hydro(hetero)ar

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fbdc40ccf8b69a766ea71e7302350808
https://doi.org/10.1039/d2sc02790a