Výsledky vyhledávání - "Lyle M. Rudensey"

Changes in the Extracellular Envelope Glycoprotein of Variants That Evolve during the Course of Simian Immunodeficiency Virus SIVMne Infection Affect Neutralizing Antibody Recognition, Syncytium Formation, and Macrophage Tropism but Not Replication, Cytopathicity, or CCR-5 Coreceptor Recognition

Autor: E. Michelle Long, Jason T. Kimata, Julie Overbaugh, Lyle M. Rudensey, Bryce Chackerian

Publikováno v: Journal of Virology. 72:209-217

Simian immunodeficiency virus SIVMne, like human immunodeficiency virus, evolves from a macrophage-tropic, non-syncytium-inducing virus at early times in infection to a T-cell-tropic, syncytium-inducing, cytopathic virus population over the course of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62427c78b428a902e3a5cb9d5686881e
https://doi.org/10.1128/jvi.72.1.209-217.1998

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Progression to AIDS in Macaques Is Associated with Changes in the Replication, Tropism, and Cytopathic Properties of the Simian Immunodeficiency Virus Variant Population

Autor: Raoul E. Benveniste, Julie Overbaugh, Jason T. Kimata, Lyle M. Rudensey

Publikováno v: Virology. 207(2):528-542

Human immunodeficiency virus type 1 (HIV-1) typically evolves from a macrophage-tropic, noncytopathic virus at early asymptomatic stages of infection to a T-cell-tropic, cytopathic, and syncytia-inducing virus population as humans progress to AIDS. T

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f53aaeac9a84cea520ec09bb45488be8

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Structure and pathogenicity of individual variants within an immunodeficiency disease-inducing isolate of FeLV

Autor: Julie Overbaugh, Lyle M. Rudensey, P. R. Donahue, Edward A. Hoover, V. Stallard, Sandra L. Quackenbush, James I. Mullins, D. P. W. Burns

Publikováno v: Virology. 188:558-569

We previously described the molecular cloning of a replication-defective variant of feline leukemia virus (FeLV) that induced fatal immunodeficiency in cats. Eighteen proviruses have now been molecularly cloned from cats inoculated with the original

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f417f882ba1270c3bb47da95f14c5de
https://doi.org/10.1016/0042-6822(92)90510-v

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Variation in simian immunodeficiency virus env is confined to V1 and V4 during progression to simian AIDS

Autor: Lyle M. Rudensey, William R. Morton, R E Benveniste, Julie Overbaugh, Mark D. Papenhausen

Publikováno v: Journal of Virology. 65:7025-7031

We have monitored changes in the simian immunodeficiency virus (SIV) envelope (env) gene in two macaques which developed AIDS after inoculation with a molecular clone of SIV. As the animals progressed to AIDS, selection occurred for viruses with vari

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f9760415c896718c012cd842bd6964aa
https://doi.org/10.1128/jvi.65.12.7025-7031.1991

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Coreceptor specificity of temporal variants of simian immunodeficiency virus Mne

Autor: Lyle M. Rudensey, Vineet N. KewalRamani, Jason T. Kimata, Dan R. Littman, Julie Overbaugh, John J. Gosink

Publikováno v: Journal of virology. 73(2)

The simian immunodeficiency virus (SIV) Mne envelope undergoes genetic changes that alter tropism, syncytium-inducing capacity, and antigenic properties of the emerging variant virus population during the course of an infection. Here we investigated

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d031a32e9c47d1fce2af22cc20c6106e
https://pubmed.ncbi.nlm.nih.gov/9882375

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Specific N-linked and O-linked glycosylation modifications in the envelope V1 domain of simian immunodeficiency virus variants that evolve in the host alter recognition by neutralizing antibodies

Autor: Lyle M. Rudensey, Julie Overbaugh, Bryce Chackerian

Publikováno v: Journal of virology. 71(10)

During progression to AIDS in simian immunodeficiency virus (SIV) Mne-infected macaques, viral variants are selected that encode sequences with serine and threonine changes in variable region 1 (V1) of the surface component of the viral envelope prot

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d7ca0e1c6c5d684533cba425c031d139
https://pubmed.ncbi.nlm.nih.gov/9311856

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Lentiviral genomes with G-to-A hypermutation may result from Taq polymerase errors during polymerase chain reaction

Autor: Julie Overbaugh, Mark D. Papenhausen, Stephanie Jackson, Lyle M. Rudensey

Publikováno v: AIDS research and human retroviruses. 12(17)

Retroviral genomes with a high frequency of G-to-A mutations are thought to originate during reverse transcription. Here we show that bursts of G-to-A mutation may also occur during DNA synthesis by Taq polymerase on a simian immunodeficiency provira

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e543287b4679926b29e4170abdadf6c2
https://pubmed.ncbi.nlm.nih.gov/9264284

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Replication and persistence of simian immunodeficiency virus variants after passage in macaque lymphocytes and established human cell lines

Autor: Lyle M. Rudensey, Mark D. Papenhausen, Julie Overbaugh

Publikováno v: Journal of virology. 67(3)

In lentivirus infections, there are typically few cells in the host that harbor the provirus. For this reason, molecular clones of human and simian immunodeficiency viruses (HIV and SIV) are generally derived after passage and amplification of the vi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed5981749904b859e17c84bd9b0f13bc
https://pubmed.ncbi.nlm.nih.gov/8437241

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Alterations in potential sites for glycosylation predominate during evolution of the simian immunodeficiency virus envelope gene in macaques

Autor: Julie Overbaugh, Lyle M. Rudensey

Publikováno v: Journal of virology. 66(10)

Genetic diversity is a hallmark of the human immunodeficiency virus (HIV) genome, but the role of distinct HIV variants in the development of AIDS is unclear. Envelope (env) is the most highly variable gene in HIV as well as in other retroviruses. We

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca41bb585396de27b4ace94c7613b5c2
https://pubmed.ncbi.nlm.nih.gov/1527847

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