Zobrazeno 1 - 10
of 3 611
pro vyhledávání: '"Lyle L"'
Autor:
Evan L. Barrios, Leandro Balzano-Nogueira, Valerie E. Polcz, Christine Rodhouse, Jack R. Leary, Dijoia B. Darden, Jaimar C. Rincon, Marvin L. Dirain, Ricardo Ungaro, Dina C. Nacionales, Shawn D. Larson, Ashish Sharma, Gilburt Upchurch, Shannon M. Wallet, Todd M. Brusko, Tyler J. Loftus, Alicia M. Mohr, Robert Maile, Rhonda Bacher, Guoshuai Cai, Michael P. Kladde, Clayton E. Mathews, Lyle L. Moldawer, Maigan A. Brusko, Philip A. Efron
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
IntroductionDespite continued improvement in post-sepsis survival, long term morbidity and mortality remain high. Chronic critical illness (CCI), defined as persistent inflammation and organ injury requiring prolonged intensive care, is a harbinger o
Externí odkaz:
https://doaj.org/article/e0557e75cb90464e859377a738355ef4
Autor:
Adam D. Price, Ellen R. Becker, Evan L. Barrios, Monty B. Mazer, Patrick W. McGonagill, Christian B. Bergmann, Michael D. Goodman, Robert W. Gould, Mahil Rao, Valerie E. Polcz, Tamara A. Kucaba, Andrew H. Walton, Sydney Miles, Julie Xu, Muxuan Liang, Tyler J. Loftus, Philip A. Efron, Kenneth E. Remy, Scott C. Brakenridge, Vladimir P. Badovinac, Thomas S. Griffith, Lyle L. Moldawer, Richard S. Hotchkiss, Charles C. Caldwell
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
IntroductionSepsis is a complex clinical syndrome characterized by a heterogenous host immune response. Historically, static protein and transcriptomic metrics have been employed to describe the underlying biology. Here, we tested the hypothesis that
Externí odkaz:
https://doaj.org/article/0d40c4cf70d04695a92503d2f0ae310b
Autor:
Michal Ben-Israel, Robert M. Holder, Lyle L. Nelson, Emily F. Smith, Andrew R. C. Kylander-Clark, Uri Ryb
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-8 (2024)
Abstract Understanding causal relationships between evolution and ocean oxygenation hinges on reliable reconstructions of marine oxygen levels, typically from redox-sensitive geochemical proxies. Here, we develop a proxy, using dolomite U–Pb geochr
Externí odkaz:
https://doaj.org/article/92ac9cdb9ce147b5b1a125041fdfdd06
Autor:
Evan L. Barrios, Jack R. Leary, Dijoia B. Darden, Jaimar C. Rincon, Micah Willis, Valerie E. Polcz, Gwendolyn S. Gillies, Jennifer A. Munley, Marvin L. Dirain, Ricardo Ungaro, Dina C. Nacionales, Marie-Pierre L. Gauthier, Shawn D. Larson, Laurence Morel, Tyler J. Loftus, Alicia M. Mohr, Robert Maile, Michael P. Kladde, Clayton E. Mathews, Maigan A. Brusko, Todd M. Brusko, Lyle L. Moldawer, Rhonda Bacher, Philip A. Efron
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
IntroductionSepsis engenders distinct host immunologic changes that include the expansion of myeloid-derived suppressor cells (MDSCs). These cells play a physiologic role in tempering acute inflammatory responses but can persist in patients who devel
Externí odkaz:
https://doaj.org/article/c3d9f1e91fd841aa9fdb8d5f4c7a4bf1
Autor:
Jeremy A. Balch, Uan-I Chen, Oliver Liesenfeld, Petr Starostik, Tyler J. Loftus, Philip A. Efron, Scott C. Brakenridge, Timothy E. Sweeney, Lyle L. Moldawer
Publikováno v:
Critical Care, Vol 27, Iss 1, Pp 1-12 (2023)
Abstract Background Sepsis is a heterogenous syndrome with limited therapeutic options. Identifying immunological endotypes through gene expression patterns in septic patients may lead to targeted interventions. We investigated whether patients admit
Externí odkaz:
https://doaj.org/article/ebd16a5d714d405c8c683d468eb7bc5b
Autor:
Thomas Daix, Armelle Mathonnet, Scott Brakenridge, Pierre-François Dequin, Jean-Paul Mira, Frederique Berbille, Michel Morre, Robin Jeannet, Teresa Blood, Jacqueline Unsinger, Jane Blood, Andrew Walton, Lyle L. Moldawer, Richard Hotchkiss, Bruno François
Publikováno v:
Annals of Intensive Care, Vol 13, Iss 1, Pp 1-11 (2023)
Abstract Background Profound lymphopenia is an independent predictor of adverse clinical outcomes in sepsis. Interleukin-7 (IL-7) is essential for lymphocyte proliferation and survival. A previous phase II study showed that CYT107, a glycosylated rec
Externí odkaz:
https://doaj.org/article/ac01ea5bbb564dde939f73024683bed3
Autor:
Abigail S. Kane, Brittany P. Boribong, Maggie Loiselle, Anagha P. Chitnis, Hector Chavez, Lyle L. Moldawer, Shawn D. Larson, Oluwakemi Badaki-Makun, Daniel Irimia, Lael M. Yonker
Publikováno v:
Frontiers in Pediatrics, Vol 11 (2023)
IntroductionAlthough SARS-CoV-2 infection can lead to severe COVID-19 in children, the role of biomarkers for assessing the risk of progression to severe disease is not well established in the pediatric population. Given the differences in monocyte s
Externí odkaz:
https://doaj.org/article/adff15a0205f476ea30e631c6b47b95c
Autor:
Lael M. Yonker, Oluwakemi Badaki-Makun, Puneeta Arya, Brittany P. Boribong, Gabriela Moraru, Brittany Fenner, Jaimar Rincon, Alex Hopke, Brent Rogers, Jeremiah Hinson, Alessio Fasano, Lilly Lee, Sarah M. Kehoe, Shawn D. Larson, Hector Chavez, Scott Levin, Lyle L. Moldawer, Daniel Irimia
Publikováno v:
BMC Infectious Diseases, Vol 22, Iss 1, Pp 1-11 (2022)
Abstract Background Multisystem inflammatory syndrome in children (MIS-C) is a life-threatening complication that can develop weeks to months after an initial SARS-CoV-2 infection. A complex, time-consuming laboratory evaluation is currently required
Externí odkaz:
https://doaj.org/article/5a4a0ff6f4bb4454aa1085ff72ab469c
Autor:
Simon A.F. Darroch, Emily F. Smith, Lyle L. Nelson, Matthew Craffey, James D. Schiffbauer, Marc Laflamme
Publikováno v:
Cambridge Prisms: Extinction, Vol 1 (2023)
Since the 1980s, the existence of one or more extinction events in the late Ediacaran has been the subject of debate. Discussion surrounding these events has intensified in the last decade, in concert with efforts to understand drivers of global chan
Externí odkaz:
https://doaj.org/article/5ccfa5a6ea254ac3a56222e0a9561c4b
Autor:
Lael M. Yonker, Oluwakemi Badaki-Makun, Puneeta Arya, Brittany P. Boribong, Gabriela Moraru, Brittany Fenner, Jaimar Rincon, Alex Hopke, Brent Rogers, Jeremiah Hinson, Alessio Fasano, Lilly Lee, Sarah M. Kehoe, Shawn D. Larson, Hector Chavez, Scott Levin, Lyle L. Moldawer, Daniel Irimia
Publikováno v:
BMC Infectious Diseases, Vol 22, Iss 1, Pp 1-3 (2022)
Externí odkaz:
https://doaj.org/article/f757014452bc4a26a43faac79f2412a2