Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Lyle John Palmer"'
Autor:
Eco De Geus, Michael Weedon, Joyce Van Meurs, Torben Jørgensen, Kirsi Pietiläinen, Patricia Munroe, Amanda Bennett, Michael Stumvoll, Andrew Hattersley, Vilmundur Gudnason, Dale Nyholt, Mary Feitosa, Mariano Dei, Marcus Dörr, Terho Lehtimäki, Anette P Gjesing, Daniel Witte, Adebowale Adeyemo, Eleanor Wheeler, Peter Kovacs, Hana Lango Allen, Philippe Froguel, Panos Deloukas, Cornelia Van Duijn, Tiinamaija Tuomi, Daniel Shriner, Struan Grant, Tonu Esko, Reedik Mägi, Lyle John Palmer, L. Adrienne Cupples, Claes Ohlsson, Krina Zondervan, Thomas Meitinger, Sarah Nyante, Lina Zgaga, Themistocles Assimes, Paul Elliott, Robert Luben, Albert Vernon Smith, MANUELA UDA, Rona Strawbridge, Richard Bergman, Gonneke Willemsen, Igor Rudan, Maris Teder-Laving, Liesbeth Vandenput, Mary Cushman, Allan Linneberg
Publikováno v:
Liu, C T, Buchkovich, M L, Winkler, T W, Heid, I M, Hottenga, J J, Boomsma, D I, de Geus, E J C, Willemsen, G, Borecki, I B, Fox, C S, Mohlke, K L, North, K E & Cupples, L A 2014, ' Multi-ethnic fine-mapping of 14 central adiposity loci ', Human Molecular Genetics, vol. 23, no. 17, pp. 4738-4744 . https://doi.org/10.1093/hmg/ddu183
Hum. Mol. Genet. 23, 4738-4744 (2014)
Human Molecular Genetics, 23(17), 4738-4744
Human Molecular Genetics, 23(17), 4738-4744. Oxford University Press
Hum. Mol. Genet. 23, 4738-4744 (2014)
Human Molecular Genetics, 23(17), 4738-4744
Human Molecular Genetics, 23(17), 4738-4744. Oxford University Press
The Genetic Investigation of Anthropometric Traits (GIANT) consortium identified 14 loci in European Ancestry (EA) individuals associated with waist-to-hip ratio (WHR) adjusted for body mass index. These loci are wide and narrowingthe signalsremains
Autor:
Kim Overvad, Julian LIttle, Bruce H.R. Wolffenbuttel, Christina Ellervik, Dale Sandler, Andres C Garcia-Montero, François L'Heureux, Victoria Burley, Ronald Stolk, Lyle John Palmer, Amalia De curtis, Franco Berrino, Jane Hoppin, Niclas Håkansson
Publikováno v:
International Journal of Epidemiology, 40(5), 1314-1328. Oxford University Press
Fortier, I, Doiron, D, Little, J, Ferretti, V, L'Heureux, F, Stolk, R P, Knoppers, B M, Hudson, T J, Burton, P R, International Harmonization Initiative & Overvad, K 2011, ' Is rigorous retrospective harmonization possible? Application of the DataSHaPER approach across 53 large studies ', International Journal of Epidemiology, vol. 40, no. 5, pp. 1314-1328 . https://doi.org/10.1093/ije/dyr106
International Journal of Epidemiology; Vol 40
International Journal of Epidemiology
Fortier, I, Doiron, D, Little, J, Ferretti, V, L'Heureux, F, Stolk, R P, Knoppers, B M, Hudson, T J, Burton, P R, International Harmonization Initiative & Overvad, K 2011, ' Is rigorous retrospective harmonization possible? Application of the DataSHaPER approach across 53 large studies ', International Journal of Epidemiology, vol. 40, no. 5, pp. 1314-1328 . https://doi.org/10.1093/ije/dyr106
International Journal of Epidemiology; Vol 40
International Journal of Epidemiology
Background Proper understanding of the roles of, and interactions between genetic, lifestyle, environmental and psycho-social factors in determining the risk of development and/or progression of chronic diseases requires access to very large high-qua
Autor:
Toos Van Beijsterveldt, Nicholas Schork, Ruth Loos, Eleftheria Zeggini, LAURA CRISPONI, Valur Emilsson, Nicole Soranzo, Ozren Polasek, Elisabeth Thiering, Elina Hypponen, Andrew Hattersley, Craig Pennell, Alexandra Lewin, ANGELO SCUTERI, Adamo Pio D'Adamo, Antje Körner, Peter Kraft, Thor Aspelund, Timo Lakka, Johannes Kettunen, Mara Marongiu, Christel Middeldorp, Mika Kähönen, Lachlan Coin, Alina Rodriguez, Terho Lehtimäki, Kalliope Panoutsopoulou, Carol Wang, Kathryn Lunetta, George Davey Smith, Debbie A Lawlor, Jianjun Liu, Nicholas Timpson, Xavier Estivill, Tuomas Kilpeläinen, Thomas Price, Mariona Bustamante, Evangelia Stergiakouli, Struan Grant, Gerard Waeber, Lyle John Palmer, Paolo Gasparini, Katja Pahkala, André Scherag, John Holloway, Carmen Iñiguez, Paul Elliott, Albert Vernon Smith, MANUELA UDA, Harri Niinikoski, Oliver Davis, Mads Melbye, Ida Surakka, Frank Geller, Rick Jansen, Mark McCarthy, Cecilia Lindgren, Hilleke Evertje Hulshoff Pol, Nicole Warrington, Ellen Demerath
Publikováno v:
Human Molecular Genetics
Human Molecular Genetics, 23(16), 4452-4464. Oxford University Press
Cousminer, D L, Stergiakouli, E, Berry, D J, Ang, W, Blokhuis, M M, Körner, A, Siitonen, N, Ntalla, I, Marinelli, M, Perry, J R B, Kettunen, J, Jansen, R, Surakka, I, Timpson, N J, Ring, S, McMahon, G, Power, C, Wang, C, Kähönen, M, Viikari, J, Lehtimäki, T, Middeldorp, C M, van Beijsterveldt, C E M, Hulshoff Pol, H E, Neef, R M, Weise, S, Pahkala, K, Niinikoski, H, Zeggini, E, Panoutsopoulou, K, Bustamante, M, Penninx, B W J H, Murabito, J, Torrent, M, Dedoussis, G V, Kiess, W, Boomsma, D I, Pennell, C E, Raitakari, O T, Hyppönen, E, Davey Smith, G, Ripatti, S, McCarthy, M I & Widen, E 2014, ' Genome-wide association study of sexual maturation in males and females highlights a role for body mass and menarche loci in male puberty ', Human Molecular Genetics, vol. 23, no. 16, pp. 4452-4464 . https://doi.org/10.1093/hmg/ddu150
Human Molecular Genetics, 23(16), 4452-4464. Oxford University Press
Cousminer, D L, Stergiakouli, E, Berry, D J, Ang, W, Blokhuis, M M, Körner, A, Siitonen, N, Ntalla, I, Marinelli, M, Perry, J R B, Kettunen, J, Jansen, R, Surakka, I, Timpson, N J, Ring, S, McMahon, G, Power, C, Wang, C, Kähönen, M, Viikari, J, Lehtimäki, T, Middeldorp, C M, van Beijsterveldt, C E M, Hulshoff Pol, H E, Neef, R M, Weise, S, Pahkala, K, Niinikoski, H, Zeggini, E, Panoutsopoulou, K, Bustamante, M, Penninx, B W J H, Murabito, J, Torrent, M, Dedoussis, G V, Kiess, W, Boomsma, D I, Pennell, C E, Raitakari, O T, Hyppönen, E, Davey Smith, G, Ripatti, S, McCarthy, M I & Widen, E 2014, ' Genome-wide association study of sexual maturation in males and females highlights a role for body mass and menarche loci in male puberty ', Human Molecular Genetics, vol. 23, no. 16, pp. 4452-4464 . https://doi.org/10.1093/hmg/ddu150
Little is known about genes regulating male puberty. Further, while many identified pubertal timing variants associate with age at menarche, a late manifestation of puberty, and body mass, little is known about these variants' relationship to puberta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a242d5b0fa02609b9cd63a2ddbad72a0
https://hdl.handle.net/1959.8/160170
https://hdl.handle.net/1959.8/160170
Autor:
Amelie Bonnefond, Nancy Heard-Costa, Eleftheria Zeggini, Anna Gloyn, LAURA CRISPONI, Eco De Geus, Michael Weedon, Torben Jørgensen, Jaakko Kaprio, Iva Miljkovic, Amanda Bennett, Yurii Aulchenko, Michael Stumvoll, Andrew Hattersley, Christian Dina, Sophie Visvikis-Siest, Udo Seedorf, Vilmundur Gudnason, Michael Marmot, Mika Kivimaki, Mary Feitosa, Danielle Posthuma, Claudia Langenberg, Stavroula Kanoni, Cyrus Cooper, Meena Kumari, Peter Kovacs, Debbie A Lawlor, Inga Prokopenko, Rafn Benediktsson, Stephen Kritchevsky, Philippe Froguel, Cornelia Van Duijn, Nita Forouhi, Anne B. Newman, Ko Willems van Dijk, John Carr, Reedik Mägi, Sutapa Mukherjee, Lyle John Palmer, Francois Pattou, L. Adrienne Cupples, Paul Franks, Paul Elliott, Albert Vernon Smith, MANUELA UDA, Kirsten Ohm Kyvik, Manuel Serrano Ríos, Richard Bergman, Gonneke Willemsen, Cecilia Lindgren, Igor Rudan
Publikováno v:
PLoS Genet. 8:e1002695 (2012)
Fox, C S, Liu, Y, White, C C, Feitosa, M, Smith, A V, Heard-Costa, N, Lohman, K, Johnson, A D, Foster, M C, Greenawalt, D M, Griffin, P, Ding, J, Newman, A B, Tylavsky, F, Miljkovic, I, Kritchevsky, S B, Launer, L, Garcia, M, Eiriksdottir, G, Carr, J J, Gudnason, V, Harris, T B, Cupples, L A, Borecki, I B & Hayward, C 2012, ' Genome-wide association for abdominal subcutaneous and visceral adipose reveals a novel locus for visceral fat in women ', PLoS Genetics, vol. 8, no. 5, pp. e1002695 . https://doi.org/10.1371/journal.pgen.1002695
PLoS Genetics, 8(5):e1002695. Public Library of Science
Fox, C S, Liu, Y, White, C C, Feitosa, M, Smith, A V, Heard-Costa, N, Lohman, K, Hottenga, J J, de Geus, E J C, Willemsen, G, Boomsma, D I, Johnson, A D, Foster, M C, Greenawalt, D M, Griffin, P, Ding, J, Newman, A B, Tylavsky, F, Miljkovic, I, Kritchevsky, S B, Launer, L, Garcia, M, Eiriksdottir, G, Posthuma, D, Carr, J J, Gudnason, V, Harris, T B, Cupples, L A & Borecki, I B 2012, ' Genome-wide association for abdominal subcutaneous and visceral adipose reveals a novel locus for visceral fat in women ', PLoS Genetics, vol. 8, no. 5, e1002695, pp. e1002695 . https://doi.org/10.1371/journal.pgen.1002695
PLoS Genetics
Fox, C S, Liu, Y, White, C C, Feitosa, M, Smith, A V, Heard-Costa, N, Lohman, K, Johnson, A D, Foster, M C, Greenawalt, D M, Griffin, P, Ding, J, Newman, A B, Tylavsky, F, Miljkovic, I, Kritchevsky, S B, Launer, L, Garcia, M, Eiriksdottir, G, Carr, J J, Gudnason, V, Harris, T B, Cupples, L A, Borecki, I B, GIANT Consortium & Kyvik, K O 2012, ' Genome-wide association for abdominal subcutaneous and visceral adipose reveals a novel locus for visceral fat in women ', P L o S Genetics, vol. 8, no. 5, pp. e1002695 . https://doi.org/10.1371/journal.pgen.1002695
PLoS Genetics, 8(5)
PLoS Genetics, Vol 8, Iss 5, p e1002695 (2012)
Plos Genetics, vol. 8, no. 5, pp. e1002695
Fox, C S, Liu, Y, White, C C, Feitosa, M, Smith, A V, Heard-Costa, N, Lohman, K, Johnson, A D, Foster, M C, Greenawalt, D M, Griffin, P, Ding, J, Newman, A B, Tylavsky, F, Miljkovic, I, Kritchevsky, S B, Launer, L, Garcia, M, Eiriksdottir, G, Carr, J J, Gudnason, V, Harris, T B, Cupples, L A, Borecki, I B, GIANT Consortium & Sandbæk, A 2012, ' Genome-wide association for abdominal subcutaneous and visceral adipose reveals a novel locus for visceral fat in women ', PLoS genetics, vol. 8, no. 5, pp. e1002695 . https://doi.org/10.1371/journal.pgen.1002695
Fox, C S, Liu, Y, White, C C, Feitosa, M, Smith, A V, Heard-Costa, N, Lohman, K, Johnson, A D, Foster, M C, Greenawalt, D M, Griffin, P, Ding, J, Newman, A B, Tylavsky, F, Miljkovic, I, Kritchevsky, S B, Launer, L, Garcia, M, Eiriksdottir, G, Carr, J J, Gudnason, V, Harris, T B, Cupples, L A, Borecki, I B & Hayward, C 2012, ' Genome-wide association for abdominal subcutaneous and visceral adipose reveals a novel locus for visceral fat in women ', PLoS Genetics, vol. 8, no. 5, pp. e1002695 . https://doi.org/10.1371/journal.pgen.1002695
PLoS Genetics, 8(5):e1002695. Public Library of Science
Fox, C S, Liu, Y, White, C C, Feitosa, M, Smith, A V, Heard-Costa, N, Lohman, K, Hottenga, J J, de Geus, E J C, Willemsen, G, Boomsma, D I, Johnson, A D, Foster, M C, Greenawalt, D M, Griffin, P, Ding, J, Newman, A B, Tylavsky, F, Miljkovic, I, Kritchevsky, S B, Launer, L, Garcia, M, Eiriksdottir, G, Posthuma, D, Carr, J J, Gudnason, V, Harris, T B, Cupples, L A & Borecki, I B 2012, ' Genome-wide association for abdominal subcutaneous and visceral adipose reveals a novel locus for visceral fat in women ', PLoS Genetics, vol. 8, no. 5, e1002695, pp. e1002695 . https://doi.org/10.1371/journal.pgen.1002695
PLoS Genetics
Fox, C S, Liu, Y, White, C C, Feitosa, M, Smith, A V, Heard-Costa, N, Lohman, K, Johnson, A D, Foster, M C, Greenawalt, D M, Griffin, P, Ding, J, Newman, A B, Tylavsky, F, Miljkovic, I, Kritchevsky, S B, Launer, L, Garcia, M, Eiriksdottir, G, Carr, J J, Gudnason, V, Harris, T B, Cupples, L A, Borecki, I B, GIANT Consortium & Kyvik, K O 2012, ' Genome-wide association for abdominal subcutaneous and visceral adipose reveals a novel locus for visceral fat in women ', P L o S Genetics, vol. 8, no. 5, pp. e1002695 . https://doi.org/10.1371/journal.pgen.1002695
PLoS Genetics, 8(5)
PLoS Genetics, Vol 8, Iss 5, p e1002695 (2012)
Plos Genetics, vol. 8, no. 5, pp. e1002695
Fox, C S, Liu, Y, White, C C, Feitosa, M, Smith, A V, Heard-Costa, N, Lohman, K, Johnson, A D, Foster, M C, Greenawalt, D M, Griffin, P, Ding, J, Newman, A B, Tylavsky, F, Miljkovic, I, Kritchevsky, S B, Launer, L, Garcia, M, Eiriksdottir, G, Carr, J J, Gudnason, V, Harris, T B, Cupples, L A, Borecki, I B, GIANT Consortium & Sandbæk, A 2012, ' Genome-wide association for abdominal subcutaneous and visceral adipose reveals a novel locus for visceral fat in women ', PLoS genetics, vol. 8, no. 5, pp. e1002695 . https://doi.org/10.1371/journal.pgen.1002695
Body fat distribution, particularly centralized obesity, is associated with metabolic risk above and beyond total adiposity. We performed genome-wide association of abdominal adipose depots quantified using computed tomography (CT) to uncover novel l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f51745aee40c86958d5af210e8d2dd9b
https://push-zb.helmholtz-muenchen.de/frontdoor.php?source_opus=8204
https://push-zb.helmholtz-muenchen.de/frontdoor.php?source_opus=8204
Autor:
Marcel Den Hoed, Ruth Loos, Eco De Geus, Marjo-Riitta Jarvelin, Elina Hypponen, Amanda Bennett, Yurii Aulchenko, Andrew Hattersley, Craig Pennell, Gerard Koppelman, David Evans, Soren Brage, Rachel Freathy, Stavroula Kanoni, Lachlan Coin, George Davey Smith, Inga Prokopenko, Tuomas Kilpeläinen, Philippe Froguel, Cornelia Van Duijn, Anders Grøntved, Struan Grant, Reedik Mägi, Lyle John Palmer, Paul O'Reilly, Julie Marsh, Fernando Rivadeneira, Paul Elliott, Adaikalavan Ramasamy, Gonneke Willemsen, Mark McCarthy, Cecilia Lindgren, Nicole Warrington
Publikováno v:
The American Journal of Clinical Nutrition, 93(4), 851-860. Oxford University press
Am. J. Clin. Nutr. 93, 851-860 (2011)
American Journal of Clinical Nutrition, 93(4), 851-860. Oxford University Press
Kilpelaeinen, T O, den Hoed, M, Ong, K K, Grontved, A, Brage, S, Jameson, K, Cooper, C, Khaw, K T, Ekelund, U, Wareham, N J, Loos, R J F & Early Growth Genetics, C 2011, ' Obesity-susceptibility loci have a limited influence on birth weight: a meta-analysis of up to 28,219 individuals ', American Journal of Clinical Nutrition, vol. 93, no. 4, pp. 851-860 . https://doi.org/10.3945/ajcn.110.000828
Kilpelaïnen, T O, van den Hoed, M, Ong, K K, Grøntved, A, Brage, S, Hottenga, J J, Willemsen, G, de Geus, E J C, Boomsma, D I, Jameson, K, Cooper, C, Khaw, K T, Ekelund, U, Wareham, N J & Loos, R J 2011, ' Obesity-susceptibility loci have a limited influence on birth weight: a meta-analysis of up to 28,219 individuals ', The American Journal of Clinical Nutrition, vol. 93, no. 4, pp. 851-860 . https://doi.org/10.3945/ajcn.110.000828
Am. J. Clin. Nutr. 93, 851-860 (2011)
American Journal of Clinical Nutrition, 93(4), 851-860. Oxford University Press
Kilpelaeinen, T O, den Hoed, M, Ong, K K, Grontved, A, Brage, S, Jameson, K, Cooper, C, Khaw, K T, Ekelund, U, Wareham, N J, Loos, R J F & Early Growth Genetics, C 2011, ' Obesity-susceptibility loci have a limited influence on birth weight: a meta-analysis of up to 28,219 individuals ', American Journal of Clinical Nutrition, vol. 93, no. 4, pp. 851-860 . https://doi.org/10.3945/ajcn.110.000828
Kilpelaïnen, T O, van den Hoed, M, Ong, K K, Grøntved, A, Brage, S, Hottenga, J J, Willemsen, G, de Geus, E J C, Boomsma, D I, Jameson, K, Cooper, C, Khaw, K T, Ekelund, U, Wareham, N J & Loos, R J 2011, ' Obesity-susceptibility loci have a limited influence on birth weight: a meta-analysis of up to 28,219 individuals ', The American Journal of Clinical Nutrition, vol. 93, no. 4, pp. 851-860 . https://doi.org/10.3945/ajcn.110.000828
Background: High birth weight is associated with adult body mass index (BMI). We hypothesized that birth weight and BMI may partly share a common genetic background. Objective: The objective was to examine the associations of 12 established BMI varia
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e768ebd60ee8cc17d2967cd4177757c
https://research.vu.nl/en/publications/fe3435f9-c7fe-4360-b3ce-e9b339ad4afb
https://research.vu.nl/en/publications/fe3435f9-c7fe-4360-b3ce-e9b339ad4afb
Autor:
Benjamin Voight, Amelie Bonnefond, Mark Caulfield, Guillaume Pare, Manal Abdelmalek, Eleftheria Zeggini, Jeffrey Schwimmer, Anna Gloyn, Michael Preuss, Åsa Johansson, LAURA CRISPONI, Eco De Geus, Michael Weedon, Jeanne Clark, Joyce Van Meurs, Torben Jørgensen, Kirsi Pietiläinen, Nicole Glazer, Jaakko Kaprio, Alan Shuldiner, Braxton Mitchell, Patricia Munroe, Ozren Polasek, Elisabeth Thiering, Carla Vogel, Jennie Hui, ROBERTO ELOSUA, Amanda Bennett, Yurii Aulchenko, Michael Stumvoll, Andrew Hattersley, Alexander Doney, Peter P Pramstaller, Christian Dina, Lambertus Kiemeney, Sophie Visvikis-Siest, ANGELO SCUTERI, Udo Seedorf, Vilmundur Gudnason, Peter Kraft, Aroon Hingorani, Michael Marmot, Dale Nyholt, Mika Kivimaki, Mary Feitosa, Danielle Posthuma, Claudia Langenberg, Stavroula Kanoni, Mika Kähönen, David Hillman, Lachlan Coin, Eric Brunner, Terho Lehtimäki, Man Li, John Beilby, Peter Visscher, Anette P Gjesing, James Pankow, Ruben Hernaez, Taina Lajunen, Katja Aben, Daniel Witte, Willem Ouwehand, Eleanor Wheeler, Peter Kovacs, Debbie A Lawlor, Kevin Jacobs, Jianjun Liu, Joseph Massaro, Hana Lango Allen, Inga Prokopenko, Rafn Benediktsson, Philippe Froguel, Soumya Raychaudhuri, Cornelia Van Duijn, Annette Peters, Nita Forouhi, Chiara Lanzani, Tonu Esko, Ko Willems van Dijk, Sadaf Farooqi, John Carr, Reedik Mägi, David Melzer, Gerard Waeber, Sutapa Mukherjee, Lyle John Palmer, Francois Pattou, Claes Ohlsson, Perry Elliott, André Scherag, Inke König, Stephen O'rahilly, Thomas Meitinger, Michael Goddard, Lina Zgaga, Robert Weyant, Paul Elliott, Robert Luben, Albert Vernon Smith, MANUELA UDA, Avan Aihie Sayer, Richard Bergman, Gonneke Willemsen, Cecilia Lindgren, Olle Melander, Igor Rudan, Maris Teder-Laving, Hugh Watkins, Ulrich John
Publikováno v:
PLoS Genetics (print), 7(3). Public Library of Science
PLoS Genetics, 7(3):e1001324. Public Library of Science
Speliotes, E K, Yerges-Armstrong, L M, Wu, J, Hernaez, R, Kim, L J, Palmer, C D, Gudnason, V, Eiriksdottir, G, Garcia, M E, Launer, L J, Nalls, M A, Clark, J M, Mitchell, B D, Shuldiner, A R, Butler, J L, Tomas, M, Hoffmann, U, Hwang, S J, Massaro, J M, O'Donnell, C J, Sahani, D V, Salomaa, V, Schadt, E E, Schwartz, S M, Siscovick, D S, Posthuma, D, Voight, B F, Carr, J J, Feitosa, M F, Harris, T B, Fox, C S, Smith, A V, Kao, W H L, Hottenga, J J, Willemsen, G, de Geus, E J C, Boomsma, D I, Hirschhorn, J N & Borecki, I B 2011, ' Genome-Wide Association Analysis Identifies Variants Associated with Nonalcoholic Fatty Liver Disease That Have Distinct Effects on Metabolic Traits ', PLoS Genetics, vol. 7, no. 3, e1001324 . https://doi.org/10.1371/journal.pgen.1001324
PLoS genetics, vol 7, iss 3
PLoS Genetics, Vol 7, Iss 3, p e1001324 (2011)
PLoS Genetics
PLoS Genetics, 7(3)
PLoS Genetics, 7(3):e1001324. Public Library of Science
Speliotes, E K, Yerges-Armstrong, L M, Wu, J, Hernaez, R, Kim, L J, Palmer, C D, Gudnason, V, Eiriksdottir, G, Garcia, M E, Launer, L J, Nalls, M A, Clark, J M, Mitchell, B D, Shuldiner, A R, Butler, J L, Tomas, M, Hoffmann, U, Hwang, S J, Massaro, J M, O'Donnell, C J, Sahani, D V, Salomaa, V, Schadt, E E, Schwartz, S M, Siscovick, D S, Posthuma, D, Voight, B F, Carr, J J, Feitosa, M F, Harris, T B, Fox, C S, Smith, A V, Kao, W H L, Hottenga, J J, Willemsen, G, de Geus, E J C, Boomsma, D I, Hirschhorn, J N & Borecki, I B 2011, ' Genome-Wide Association Analysis Identifies Variants Associated with Nonalcoholic Fatty Liver Disease That Have Distinct Effects on Metabolic Traits ', PLoS Genetics, vol. 7, no. 3, e1001324 . https://doi.org/10.1371/journal.pgen.1001324
PLoS genetics, vol 7, iss 3
PLoS Genetics, Vol 7, Iss 3, p e1001324 (2011)
PLoS Genetics
PLoS Genetics, 7(3)
Nonalcoholic fatty liver disease (NAFLD) clusters in families, but the only known common genetic variants influencing risk are near PNPLA3. We sought to identify additional genetic variants influencing NAFLD using genome-wide association (GWA) analys
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da6a087b46b57b1d80a3ac0f6f2a0890
https://pure.eur.nl/en/publications/2db8f511-49f4-4120-8115-915411e3636a
https://pure.eur.nl/en/publications/2db8f511-49f4-4120-8115-915411e3636a
Autor:
Benjamin Voight, Amelie Bonnefond, Mark Caulfield, Jong-Young Lee, Ruth Loos, Nancy Heard-Costa, Eleftheria Zeggini, Cristiano FAVA, Anna Gloyn, Michael Preuss, Åsa Johansson, LAURA CRISPONI, Eco De Geus, Michael Weedon, Jeanne Clark, Francesco CUCCA, Marjo-Riitta Jarvelin, Torben Jørgensen, Andrea Maschio, Kirsi Pietiläinen, Nicole Glazer, Jaakko Kaprio, Valur Emilsson, Goncalo Abecasis, Andrew Taylor, Nicole Soranzo, Serena Sanna, Patricia Munroe, Ozren Polasek, Jan A. Staessen, Jennie Hui, Elina Hypponen, ROBERTO ELOSUA, Yurii Aulchenko, Michael Stumvoll, Andrew Hattersley, Bruce H.R. Wolffenbuttel, Alexander Doney, Peter P Pramstaller, Christian Dina, Lambertus Kiemeney, Sophie Visvikis-Siest, Mohammad Arfan Ikram, ANGELO SCUTERI, Udo Seedorf, Behrooz Ziad Alizadeh, John Whitfield, Vilmundur Gudnason, Maris Laan, Chris Wallace, Gavin Lucas, E Shyong Tai, Peter Kraft, Michael Marmot, Thor Aspelund, Dale Nyholt, Christian Gieger, Mika Kivimaki, Michael Sternberg, Lorena Citterio, Weiguo Zhang, Mary Feitosa, María Soler Artigas, Claudia Langenberg, Mika Ala-Korpela, Stavroula Kanoni, Uwe Völker, Mika Kähönen, Tomonori Okamura, Marcus Dörr, David Hillman, Lachlan Coin, Gideon Hirschfield, Eric Brunner, Maryam Kavousi, Terho Lehtimäki, Man Li, Carsten Oliver Schmidt, John Beilby, Peter Visscher, Sally Ricketts, Katja Aben, Halit Ongen, Christie Ballantyne, Adebowale Adeyemo, Fabio Marroni, Willem Ouwehand, Toby Johnson, Meena Kumari, Peter Kovacs, Debbie A Lawlor, Jianjun Liu, Grant Montgomery, Nicholas Martin, Francesco Mattace-Raso, Inga Prokopenko, Rafn Benediktsson, Margus Viigimaa, Peter Würtz, Philippe Froguel, Fadi Charchar, Soumya Raychaudhuri, Wolfram Goessling, Alena Yaluri, Cornelia Van Duijn, Timothy Frayling, Daniel Shriner, Nita Forouhi, Jana Van Vliet-Ostaptchouk, Bram Prins, Peter Whincup, David MASSON, Ronald Stolk, Ayse Demirkan, Janoš Terzić, James Pirruccello, Maciej Tomaszewski, Martin Tobin, Ko Willems van Dijk, John Carr, Elin Org, Reedik Mägi, Xiaofeng Zhu, Gerard Waeber, Koichi Matsuda, Winston Hide, Lyle John Palmer, Francois Pattou, Dorairaj Prabhakaran, Markus M. Lerch, Mark Wass, Claes Ohlsson, Paul O'Reilly, Vasiliki Lagou, Pedro Marques-Vidal, Sudha Seshadri, Tom Gaunt, Peter Wurz, Giriraj Ratan Chandak, Louise Wain, Antti Kangas, Matthijs Boekholdt, Niels Grarup, Jemma Hopewell, Thomas Meitinger, Lina Zgaga, Dag Steinar Thelle, Robert Weyant, Thomas Wang, Paul Elliott, Robert Luben, Albert Vernon Smith, Vinod Kumar, Pankaj Arora, MANUELA UDA, Daniel Gudbjartsson, Avan Aihie Sayer, Christa Meisinger, Kirsten Ohm Kyvik, Ming-Huei Chen, Susana Eyheramendy, Kenechi Ejebe, Stephen E Humphries, Ioanna Tzoulaki, Florian Kronenberg, Richard Bergman, Laura Zagato, Carlo Rivolta, NILUFER RAHMIOGLU, Vasan Ramachandran, Anna Dominiczak, Gonneke Willemsen, Mark McCarthy, Cecilia Lindgren, Olle Melander, Igor Rudan, Xueling Sim, Hugh Watkins, Edward Lakatta
Publikováno v:
Nature Genetics, 43, 11, pp. 1131-8
Nature genetics
Nature genetics, 43(11), 1131-U129. Nature Publishing Group
Nature Genetics, 43, 1131-8
Nature Genetics, 43(11), 1131-1140. Nature Publishing Group
Kyvik, K O 2011, ' Genome-wide association study identifies loci influencing concentration of liver enzymes in plasma ', Nature Genetics, vol. 43, no. 11, pp. 1131-38 . https://doi.org/10.1038/ng.970
Chambers, J C, Zhang, W, Sehmi, J, Li, X, Wass, M N, Van der Harst, P, Holm, H, Sanna, S, Kavousi, M, Baumeister, S E, Coin, L J, Deng, G, Gieger, C, Heard-Costa, N L, Hottenga, J-J, Kühnel, B, Kumar, V, Lagou, V, Liang, L, Luan, J, Vidal, P M, Mateo Leach, I, O'Reilly, P F, Peden, J F, Rahmioglu, N, Soininen, P, Speliotes, E K, Yuan, X, Thorleifsson, G, Alizadeh, B Z, Atwood, L D, Borecki, I B, Brown, M J, Charoen, P, Cucca, F, Das, D, de Geus, E J C, Dixon, A L, Döring, A, Ehret, G, Eyjolfsson, G I, Farrall, M, Forouhi, N G, Friedrich, N, Goessling, W, Gudbjartsson, D F, Harris, T B, Hartikainen, A-L, Heath, S & Hayward, C 2011, ' Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasma ', Nature Genetics, vol. 43, no. 11, pp. 1131-8 . https://doi.org/10.1038/ng.970
Nature Genetics, 43(11), 1131-U129. Nature Publishing Group
Nature Genetics
Nature Genetics, 43(11), 1131-U129
Chambers, J C, Zhang, W, Sehmi, J, Li, X, Wass, M N, van der Harst, P, Holm, H, Sanna, S, Kavousi, M, Baumeister, S E, Hottenga, J J, Speliotes, E K, de Geus, E J C, Martin, N G, Montgomery, G W, Penninx, B W J H, Prokopenko, I, Spector, T D, Uitterlinden, A G, Willemsen, G, Abecasis, G R, Boomsma, D I, van Duijn, C M, Snieder, H, Whitfield, J B, Witteman, J C M, Fox, C S, Ala-Korpela, M, Stefansson, K, Vollenweider, P, Völzke, H, Schadt, E E, Scott, J, Jarvelin, M R, Elliot, P & Kooner, J S 2011, ' Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasma ', Nature Genetics, vol. 43, no. 11, pp. 1131-1140 . https://doi.org/10.1038/ng.970
Nature Genetics, Vol. 43, No 11 (2011) pp. 1131-8
Nature Genetics; Vol 43
Nature genetics
Nature genetics, 43(11), 1131-U129. Nature Publishing Group
Nature Genetics, 43, 1131-8
Nature Genetics, 43(11), 1131-1140. Nature Publishing Group
Kyvik, K O 2011, ' Genome-wide association study identifies loci influencing concentration of liver enzymes in plasma ', Nature Genetics, vol. 43, no. 11, pp. 1131-38 . https://doi.org/10.1038/ng.970
Chambers, J C, Zhang, W, Sehmi, J, Li, X, Wass, M N, Van der Harst, P, Holm, H, Sanna, S, Kavousi, M, Baumeister, S E, Coin, L J, Deng, G, Gieger, C, Heard-Costa, N L, Hottenga, J-J, Kühnel, B, Kumar, V, Lagou, V, Liang, L, Luan, J, Vidal, P M, Mateo Leach, I, O'Reilly, P F, Peden, J F, Rahmioglu, N, Soininen, P, Speliotes, E K, Yuan, X, Thorleifsson, G, Alizadeh, B Z, Atwood, L D, Borecki, I B, Brown, M J, Charoen, P, Cucca, F, Das, D, de Geus, E J C, Dixon, A L, Döring, A, Ehret, G, Eyjolfsson, G I, Farrall, M, Forouhi, N G, Friedrich, N, Goessling, W, Gudbjartsson, D F, Harris, T B, Hartikainen, A-L, Heath, S & Hayward, C 2011, ' Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasma ', Nature Genetics, vol. 43, no. 11, pp. 1131-8 . https://doi.org/10.1038/ng.970
Nature Genetics, 43(11), 1131-U129. Nature Publishing Group
Nature Genetics
Nature Genetics, 43(11), 1131-U129
Chambers, J C, Zhang, W, Sehmi, J, Li, X, Wass, M N, van der Harst, P, Holm, H, Sanna, S, Kavousi, M, Baumeister, S E, Hottenga, J J, Speliotes, E K, de Geus, E J C, Martin, N G, Montgomery, G W, Penninx, B W J H, Prokopenko, I, Spector, T D, Uitterlinden, A G, Willemsen, G, Abecasis, G R, Boomsma, D I, van Duijn, C M, Snieder, H, Whitfield, J B, Witteman, J C M, Fox, C S, Ala-Korpela, M, Stefansson, K, Vollenweider, P, Völzke, H, Schadt, E E, Scott, J, Jarvelin, M R, Elliot, P & Kooner, J S 2011, ' Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasma ', Nature Genetics, vol. 43, no. 11, pp. 1131-1140 . https://doi.org/10.1038/ng.970
Nature Genetics, Vol. 43, No 11 (2011) pp. 1131-8
Nature Genetics; Vol 43
Concentrations of liver enzymes in plasma are widely used as indicators of liver disease. We carried out a genome-wide association study in 61,089 individuals, identifying 42 loci associated with concentrations of liver enzymes in plasma, of which 32
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7edb28f9648063ec49efcad3a2ef319a
https://hdl.handle.net/2066/95932
https://hdl.handle.net/2066/95932
Autor:
Amelie Bonnefond, Eleftheria Zeggini, Anna Gloyn, LAURA CRISPONI, Eco De Geus, Michael Weedon, Torben Jørgensen, Jaakko Kaprio, Achia Urbach, Amanda Bennett, Yurii Aulchenko, Michael Stumvoll, Andrew Hattersley, Christian Dina, Sophie Visvikis-Siest, David Altshuler, Udo Seedorf, Mika Kivimaki, Irene Pichler, Danielle Posthuma, Claudia Langenberg, Stavroula Kanoni, Hao Zhu, Cristian Pattaro, Meena Kumari, John Hagan, Ng Shyh-Chang, Rafn Benediktsson, Philippe Froguel, Cornelia Van Duijn, David Couper, Jana Van Vliet-Ostaptchouk, Ko Willems van Dijk, Reedik Mägi, Winston Hide, Sutapa Mukherjee, Lyle John Palmer, Francois Pattou, Thomas Meitinger, MANUELA UDA, Kirsten Ohm Kyvik, Richard Bergman, Gonneke Willemsen, Cecilia Lindgren, Igor Rudan
Publikováno v:
Zhu, H, Shyh-Chang, N, Segre, A V, Shinoda, G, Shah, S P, Einhorn, W S, Takeuchi, A, Engreitz, J M, Hagan, J P, Kharas, M G, Urbach, A, Thornton, J E, Triboulet, R, Gregory, R I, Hottenga, J J, de Geus, E J C, Posthuma, D, Willemsen, G, Boomsma, D I, Altshuler, D & Daley, G Q 2011, ' The Lin28/let-7 axis regulates glucose metabolism ', Cell, vol. 147, no. 1, pp. 81-94 . https://doi.org/10.1016/j.cell.2011.08.033
Kyvik, K O 2011, ' The Lin28/let-7-axis regulates glucose metabolism ', Cell, vol. 147, no. 1, pp. 81-94 . https://doi.org/10.1016/j.cell.2011.08.033
Cell, 147(1), 81-94. Cell Press
Cell, 147(1), 81-94. CELL PRESS
Cell, 147(1), 81-94
Cell 147, 81-94 (2011)
Kyvik, K O 2011, ' The Lin28/let-7-axis regulates glucose metabolism ', Cell, vol. 147, no. 1, pp. 81-94 . https://doi.org/10.1016/j.cell.2011.08.033
Cell, 147(1), 81-94. Cell Press
Cell, 147(1), 81-94. CELL PRESS
Cell, 147(1), 81-94
Cell 147, 81-94 (2011)
The let-7 tumor suppressor microRNAs are known for their regulation of oncogenes, while the RNA-binding proteins Lin28a/b promote malignancy by blocking let-7 biogenesis. In studies of the Lin28/let-7 pathway, we discovered unexpected roles in regula
Autor:
Maxim Freydin, Göran Pershagen, Florence Demenais, Torben Sigsgaard, Ashish Kumar, Jennie Hui, Juha Kere, Erika Von Mutius, Inger Kull, Robert Niven, Fredrik Nyberg, John Beilby, Inge M. Wouters, Benedicte Leynaert, Ian Sayers, Aristea Binia, Jon Genuneit, Maria Solodilova, Peter Burney, Angela Simpson, Dick Heederik, Vivi Schlünssen, Marie-Hélène Dizier, David Balding, Ioannis Basinas, Alexandra Karunas, Olga Kobyakova, Karl Franklin, Lyle John Palmer, Deborah Jarvis, Yuliya Fedorova, John Holloway, Mona Bafadhel, Elza Khusnutdinova, Roel Vermeulen, Joachim Heinrich
Publikováno v:
New England journal of medicine, 363(13), 1211-1221. Massachussetts Medical Society
New England Journal of Medicine, 363(13), 1211. Massachussetts Medical Society
Moffatt, M F, Gut, I G, Demenais, F, Strachan, D P, Bouzigon, E, Heath, S, von Mutius, E, Farrall, M, Lathrop, M, Cookson, W O C M, GABRIEL Consortium, Sigsgaard, T, Schlünssen, V, Basinas, I & Omland, Ø 2010, ' A large-scale, consortium-based genomewide association study of asthma ', The New England Journal of Medicine, vol. 363, no. 13, pp. 1211-21 . https://doi.org/10.1056/NEJMoa0906312
New England Journal of Medicine
New England Journal of Medicine, 2010, 363 (13), pp.1211-21. ⟨10.1056/NEJMoa0906312⟩
New England Journal of Medicine, Massachusetts Medical Society, 2010, 363 (13), pp.1211-21. ⟨10.1056/NEJMoa0906312⟩
New England Journal of Medicine, 363(13), 1211-1221. MASSACHUSETTS MEDICAL SOC
N. Engl. J. Med. 363, 1211-1221 (2010)
New England Journal of Medicine, 363(13), 1211. Massachussetts Medical Society
Moffatt, M F, Gut, I G, Demenais, F, Strachan, D P, Bouzigon, E, Heath, S, von Mutius, E, Farrall, M, Lathrop, M, Cookson, W O C M, GABRIEL Consortium, Sigsgaard, T, Schlünssen, V, Basinas, I & Omland, Ø 2010, ' A large-scale, consortium-based genomewide association study of asthma ', The New England Journal of Medicine, vol. 363, no. 13, pp. 1211-21 . https://doi.org/10.1056/NEJMoa0906312
New England Journal of Medicine
New England Journal of Medicine, 2010, 363 (13), pp.1211-21. ⟨10.1056/NEJMoa0906312⟩
New England Journal of Medicine, Massachusetts Medical Society, 2010, 363 (13), pp.1211-21. ⟨10.1056/NEJMoa0906312⟩
New England Journal of Medicine, 363(13), 1211-1221. MASSACHUSETTS MEDICAL SOC
N. Engl. J. Med. 363, 1211-1221 (2010)
BACKGROUND: Susceptibility to asthma is influenced by genes and environment; implicated genes may indicate pathways for therapeutic intervention. Genetic risk factors may be useful in identifying subtypes of asthma and determining whether intermediat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f936700f98b6bfe65b607e6cb5447627
https://pure.amc.nl/en/publications/a-largescale-consortiumbased-genomewide-association-study-of-asthma(19b9a631-76fd-4f8d-bc3d-ae47c8c67756).html
https://pure.amc.nl/en/publications/a-largescale-consortiumbased-genomewide-association-study-of-asthma(19b9a631-76fd-4f8d-bc3d-ae47c8c67756).html
Publikováno v:
ResearcherID
Europe PubMed Central
Europe PubMed Central
We apply different family-based association test (FBAT) statistics for age of onset traits to the Genetics Analysis Workshop 12, problem 2 data. To evaluate different FBAT statistics we used the software package FBAT, which allows one to evaluate any