Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Lyle J. Arnold"'
Autor:
Jason C Poole, Shan-Fu Wu, Timothy T Lu, Cecile Rose T Vibat, Anh Pham, Errin Samuelsz, Manisha Patel, Jeffrey Chen, Tony Daher, Veena M Singh, Lyle J Arnold
Publikováno v:
PLoS ONE, Vol 14, Iss 10, p e0223112 (2019)
BackgroundPersonalized medicine requires accurate molecular profiling for targeted therapy decisions. Insufficient tissue yield or tumor heterogeneity frequently limits the correct tissue biomarker determination. As a noninvasive complement to tradit
Externí odkaz:
https://doaj.org/article/ddb7907e25c84418a98c0e082043cc61
This protocol is for the Aegea Biotechnologies rapid PCR-based SARS-CoV-2 test. This assay uses patented "Switch-Blocker" technology as well as taqman probes to test for presence of SARS-CoV-2 and simultaneously orthogonally validate. A single amplif
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a32583d7111e773478678f8b0dc4d4f5
https://doi.org/10.17504/protocols.io.bk2dkya6
https://doi.org/10.17504/protocols.io.bk2dkya6
Autor:
Lyle J. Arnold, Jeffrey H. Chen, Cecile Rose T. Vibat, Timothy T. Lu, Tony Daher, Anh Pham, Veena M. Singh, Manisha Patel, Jason C. Poole, Errin Samuelsz, Shan-Fu Wu
Publikováno v:
PLoS ONE
PLoS ONE, Vol 14, Iss 10, p e0223112 (2019)
PLoS ONE, Vol 14, Iss 10, p e0223112 (2019)
BackgroundPersonalized medicine requires accurate molecular profiling for targeted therapy decisions. Insufficient tissue yield or tumor heterogeneity frequently limits the correct tissue biomarker determination. As a noninvasive complement to tradit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5792d35395e85d82186e3f26757f77ae
http://europepmc.org/articles/PMC6776432
http://europepmc.org/articles/PMC6776432
Publikováno v:
Cancer Research. 79:2300-2300
Background: Acquired resistance to anti-hormonal therapy is a common reason for treatment failure in advanced and metastatic breast cancer (mBRC). Mutations in the ESR1 gene, encoding the estrogen receptor (ER) protein, are often associated with this
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d98d68b210a06993304e1f6cd90f7d02
https://doi.org/10.1158/1538-7445.am2019-2300
https://doi.org/10.1158/1538-7445.am2019-2300
Autor:
Jeffrey C. Chen, Timothy T. Lu, Lyle J. Arnold, Shan-Fu Wu, Jason C. Poole, Veena M. Singh, Anh Pham
Publikováno v:
Clinical Cancer Research. 24:A20-A20
Background: Liquid biopsies represent a noninvasive alternative to traditional tissue biopsies, enabling the detection and tracking of cancer driver mutations from a simple blood draw. Biocept’s Target SelectorTM test platform offers the unique abi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8cbb60d6a65b009cd0ec2778a51dc684
https://doi.org/10.1158/1557-3265.aacriaslc18-a20
https://doi.org/10.1158/1557-3265.aacriaslc18-a20
Autor:
Anh Pham, Tony Daher, Jason C. Poole, Errin Samuelsz, Veena M. Singh, Timothy T. Lu, Manisha Patel, Shan-Fu Wu, Jeffrey C. Chen, Lyle J. Arnold
Publikováno v:
Cancer Research. 78:4534-4534
Background: Accurate detection of driver mutations in cancer patients is vital for targeted therapy. Compared to tissue biopsy, “liquid biopsy” offers a non-invasive and more systemic approach to identify tumor mutations by assessing circulating
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c39b8223bed3441fb3821a6947d17756
https://doi.org/10.1158/1538-7445.am2018-4534
https://doi.org/10.1158/1538-7445.am2018-4534
Autor:
Jeff Chen, Anh Pham, Brian Kudlow, Josh Stahl, Jill Stefanelli, Jason C. Poole, Skyler Mishkin, Lyle J. Arnold, Veena M. Singh
Publikováno v:
Cancer Research. 77:762-762
Biocept’s Target Selector technology is a targeted hotspot mutation panel designed to enrich for mutant targets in a large excess of WT DNA. The test is specific to small regions of interest, is highly sensitive, validated down to 7 mutant copies i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9453be6076d9368eedad9d6267989e84
https://doi.org/10.1158/1538-7445.am2017-762
https://doi.org/10.1158/1538-7445.am2017-762
Publikováno v:
Journal of Clinical Oncology. 35:e23033-e23033
e23033 Background: Targeted cancer therapy relies on identifying specific DNA mutations from a patient’s tumor. Tyrosine kinase inhibitors (TKIs) tend to be effective for non-small cell lung cancer (NSCLC) with epidermal growth factor receptor (EGF
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::634205da078aabb171ed94b9ba2bd15a
https://doi.org/10.1200/jco.2017.35.15_suppl.e23033
https://doi.org/10.1200/jco.2017.35.15_suppl.e23033
Autor:
Deepa S. Subramaniam, Stephen V. Liu, Syed P. Hasan, Frans Beerkens, Giuseppe Giaccone, Chul Kim, Veena M. Singh, Cecile Rose T. Vibat, Lyle J. Arnold
Publikováno v:
Journal of Clinical Oncology. 35:e23037-e23037
e23037 Background: EGFR mutations are the most frequent targetable genomic alterations in non-small cell lung cancer (NSCLC) patients (pts). While tissue biopsy remains the standard for assessing of EGFR mutation status, it is invasive and not always
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d30402160d893a0b520c05177877ab2e
https://doi.org/10.1200/jco.2017.35.15_suppl.e23037
https://doi.org/10.1200/jco.2017.35.15_suppl.e23037
Autor:
Timothy A. Riley, Lyle J. Arnold, Michael Scurria, William B. Marvin, Christine D. Garcia, Stephanie A. Hopkins, William J. Daily, David A. Schwartz, Michael C. Pirrung, Michael B. Atkins
Publikováno v:
Nucleosides and Nucleotides. 16:417-432
A diastereoselective dinucleoside methylphosphonate synthetic method that features coupling of diastereomerically pure 1,1,1,3,3,3-hexafluoro-2-propyl nucleoside-3′-O-methylphosphonate monomers with 3′-O-protected nucleoside monomers mediated by
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::805906a537151e5e215353bcb1f650bc
https://doi.org/10.1080/07328319708001359
https://doi.org/10.1080/07328319708001359