Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Lyle D. Bighley"'
Publikováno v:
Annals of Pharmacotherapy. 40:1417-1423
Use of recommended IV aminophylline dosage regimens in 48 older, acutely ill, hospitalized patients with chronic obstructive pulmonary disease (COPD) resulted in excessive plasma theophylline concentrations in 29 percent of these patients. A mean dos
Publikováno v:
American Journal of Health-System Pharmacy. 31:736-739
Autor:
Lyle D. Bighley, J. Patrick McDonnell
Publikováno v:
Journal of Pharmaceutical Sciences. 64:1549-1553
A high-speed liquid chromatographic method for analysis of sulfasalazine (salicylazosulfapyridine) in bulk powder and tablet dosage form is presented. Analysis is accomplished with a reverse-phase partition column and 10% 2-propanol in pH 7.7 phospha
Publikováno v:
American Journal of Health-System Pharmacy. 34:496-503
Drug-induced modification of the spectrophotometric theophylline plasma measurement was investigated in vitro using 14 drugs which coextract with theophylline and absorb ultraviolet light in the same wavelength region. Plasma samples spiked with 15 m
Autor:
John L. Lach, Lyle D. Bighley
Publikováno v:
Journal of Pharmaceutical Sciences. 59:1261-1264
Tetracycline and its derivatives, bishydroxycoumarin, and methantheline bromide have been studied by diffuse reflectance spectroscopy for possible solid-solid interactions with various metallic adjuvants. Examination of the spectra of some of these d
Publikováno v:
American Journal of Health-System Pharmacy. 34:525-527
The absolute bioavailability of theophylline was investigated by comparing the areas under concentration-time curves for intravenous theophylline with a plain uncoated anhydrous theophylline tablet and a theophylline solution. Twenty asthmatic adults
Publikováno v:
Journal of pharmaceutical sciences. 66(1)
Autor:
R.J. Spivey, Lyle D. Bighley
Publikováno v:
Journal of pharmaceutical sciences. 66(8)
A magnesium chelate of dicumarol was prepared by reacting a suspension of dicumarol and magnesium oxide in 50% water-methanol. GLC, thermogravimetric, and elemental analyses showed that this compound has a 2:1 ligand-metal stoichiometry with 2 moles
Publikováno v:
Journal of chromatography. 110(2)
A sensitive analysis of pentaerythritol in plasma has been devised, based on the formation or its tetra- p -methoxybenzoate derivative and high-performance liquid chromatography employing an ultraviolet photometric detector. The method permits analys
Publikováno v:
Journal of pharmaceutical sciences. 60(11)
The results obtained in this study show that individual solubility profiles may be of no value for predicting the equilibrium solubility of mixtures of drugs, particularly when the drugs are capable of interacting in solution to form a very insoluble