Zobrazeno 1 - 10
of 145
pro vyhledávání: '"Lyle Armstrong"'
Autor:
Marina Moya-Molina, Birthe Dorgau, Emily Flood, Stef J. F. Letteboer, Esben Lorentzen, Jonathan Coxhead, Graham Smith, Ronald Roepman, Sushma Nagaraja Grellscheid, Lyle Armstrong, Majlinda Lako
Publikováno v:
Cell Death and Disease, Vol 15, Iss 10, Pp 1-17 (2024)
Abstract Alternative splicing (AS) is a crucial mechanism contributing to proteomic diversity, which is highly regulated in tissue- and development-specific patterns. Retinal tissue exhibits one of the highest levels of AS. In particular, photorecept
Externí odkaz:
https://doaj.org/article/6ac21c2cb7924f1387437c17d929f6bd
Autor:
Robert Atkinson, Maria Georgiou, Chunbo Yang, Katarzyna Szymanska, Albert Lahat, Elton J. R. Vasconcelos, Yanlong Ji, Marina Moya Molina, Joseph Collin, Rachel Queen, Birthe Dorgau, Avril Watson, Marzena Kurzawa-Akanbi, Ross Laws, Abhijit Saxena, Chia Shyan Beh, Chileleko Siachisumo, Franziska Goertler, Magdalena Karwatka, Tracey Davey, Chris F. Inglehearn, Martin McKibbin, Reinhard Lührmann, David H. Steel, David J. Elliott, Lyle Armstrong, Henning Urlaub, Robin R. Ali, Sushma-Nagaraja Grellscheid, Colin A. Johnson, Sina Mozaffari-Jovin, Majlinda Lako
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-17 (2024)
Abstract The carboxy-terminus of the spliceosomal protein PRPF8, which regulates the RNA helicase Brr2, is a hotspot for mutations causing retinitis pigmentosa-type 13, with unclear role in human splicing and tissue-specificity mechanism. We used pat
Externí odkaz:
https://doaj.org/article/543dcbabd0154436a3a7c83f1dd4c6bd
Autor:
Birthe Dorgau, Joseph Collin, Agata Rozanska, Veronika Boczonadi, Marina Moya-Molina, Adrienne Unsworth, Rafiqul Hussain, Jonathan Coxhead, Tamil Dhanaseelan, Lyle Armstrong, Rachel Queen, Majlinda Lako
Publikováno v:
iScience, Vol 27, Iss 4, Pp 109397- (2024)
Summary: Molecular information on the early stages of human retinal development remains scarce due to limitations in obtaining early human eye samples. Pluripotent stem cell-derived retinal organoids (ROs) provide an unprecedented opportunity for stu
Externí odkaz:
https://doaj.org/article/75b0f3cd2f454035b6357992656fba5c
Investigating light sensitivity in bipolar disorder (HELIOS-BD) [version 1; peer review: 2 approved]
Autor:
Amber Roguski, Iain H. Campbell, Lyle Armstrong, Amy Ferguson, Baljean Dhillon, Majlinda Lako, Gerrit Hilgen, Jasna Martinovic, Tom MacGillivray, Renata L. Riha, Nicole Needham, Nayantara Santhi, Philipp Ritter, Manuel Spitschan, Malcolm von Schantz, Daniel J. Smith
Publikováno v:
Wellcome Open Research, Vol 9 (2024)
Many people with bipolar disorder have disrupted circadian rhythms. This means that the timing of sleep and wake activities becomes out-of-sync with the standard 24-hour cycle. Circadian rhythms are strongly influenced by light levels and previous re
Externí odkaz:
https://doaj.org/article/761cc507071142ba9f8d01dcffb2488f
Autor:
Lyle Armstrong, Majlinda Lako
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 11 (2023)
Externí odkaz:
https://doaj.org/article/5b27177eedd1401db5fcabc38fcc3057
Autor:
Marzena Kurzawa‐Akanbi, Phillip Whitfield, Florence Burté, Pietro Maria Bertelli, Varun Pathak, Mary Doherty, Birthe Hilgen, Lina Gliaudelytė, Mark Platt, Rachel Queen, Jonathan Coxhead, Andrew Porter, Maria Öberg, Daniela Fabrikova, Tracey Davey, Chia Shyan Beh, Maria Georgiou, Joseph Collin, Veronika Boczonadi, Anetta Härtlova, Michael Taggart, Jumana Al‐Aama, Viktor I Korolchuk, Christopher M Morris, Jasenka Guduric‐Fuchs, David H Steel, Reinhold J Medina, Lyle Armstrong, Majlinda Lako
Publikováno v:
Journal of Extracellular Vesicles, Vol 11, Iss 12, Pp n/a-n/a (2022)
Abstract Age‐related macular degeneration (AMD) is a leading cause of blindness. Vision loss is caused by the retinal pigment epithelium (RPE) and photoreceptors atrophy and/or retinal and choroidal angiogenesis. Here we use AMD patient‐specific
Externí odkaz:
https://doaj.org/article/1398b9e7c68548ba80b5a5b5d9c80bee
Autor:
Lyle Armstrong, Joseph Collin, Islam Mostafa, Rachel Queen, Francisco C. Figueiredo, Majlinda Lako
Publikováno v:
Stem Cells Translational Medicine, Vol 10, Iss 7, Pp 976-986 (2021)
Abstract Severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) first emerged in December 2019 and spread quickly causing the coronavirus disease 2019 (COVID‐19) pandemic. Recent single cell RNA‐Seq analyses have shown the presence of S
Externí odkaz:
https://doaj.org/article/e3d062444ceb42a1bfcf35e02a9081e1
Autor:
Maria Georgiou, Chunbo Yang, Robert Atkinson, Kuan‐Ting Pan, Adriana Buskin, Marina Moya Molina, Joseph Collin, Jumana Al‐Aama, Franziska Goertler, Sebastian E. J. Ludwig, Tracey Davey, Reinhard Lührmann, Sushma Nagaraja‐Grellscheid, Colin A. Johnson, Robin Ali, Lyle Armstrong, Viktor Korolchuk, Henning Urlaub, Sina Mozaffari‐Jovin, Majlinda Lako
Publikováno v:
Clinical and Translational Medicine, Vol 12, Iss 3, Pp n/a-n/a (2022)
Abstract Introduction Mutations in pre‐mRNA processing factor 31 (PRPF31), a core protein of the spliceosomal tri‐snRNP complex, cause autosomal‐dominant retinitis pigmentosa (adRP). It has remained an enigma why mutations in ubiquitously expre
Externí odkaz:
https://doaj.org/article/d0deada325104e39a8d523ef7fabc4d6
Autor:
Chunbo Yang, Maria Georgiou, Robert Atkinson, Joseph Collin, Jumana Al-Aama, Sushma Nagaraja-Grellscheid, Colin Johnson, Robin Ali, Lyle Armstrong, Sina Mozaffari-Jovin, Majlinda Lako
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
Retinitis pigmentosa (RP) is the most common inherited retinal disease characterized by progressive degeneration of photoreceptors and/or retinal pigment epithelium that eventually results in blindness. Mutations in pre-mRNA processing factors (PRPF3
Externí odkaz:
https://doaj.org/article/f68e9ad4e4a948848fba0445af61964a
Autor:
Maria Georgiou, Valeria Chichagova, Gerrit Hilgen, Birthe Dorgau, Evelyne Sernagor, Lyle Armstrong, Majlinda Lako
Publikováno v:
PLoS ONE, Vol 15, Iss 6, p e0233860 (2020)
The generation of laminated and light responsive retinal organoids from induced pluripotent stem cells (iPSCs) provides a powerful tool for the study of retinal diseases and drug discovery and a robust platform for cell-based therapies. The aim of th
Externí odkaz:
https://doaj.org/article/94c41d09b84e44518d9a9abf9646d13b