Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Lye Lin Lock"'
Autor:
Zheng Jian Li, Honggang Cui, Jason Mills, Xuankuo Xu, David Stern, Lye Lin Lock, Shih-Hao Ou, Sanchayita Ghose, Marina Morrow, Yi Li
Publikováno v:
Acta Biomaterialia. 95:73-90
Downstream processing is considered one of the most challenging phases of industrial manufacturing of therapeutic proteins, accounting for a large portion of the total production costs. The growing demand for therapeutic proteins in the biopharmaceut
Autor:
Marina Morrow, Yi Li, Jason Mills, Xuankuo Xu, Ben S. Ou, Sanchayita Ghose, Caleb F. Anderson, Zheng Jian Li, Honggang Cui, Lye Lin Lock, David Stern, Han Wang
Publikováno v:
Nano letters. 20(10)
The separation and purification of therapeutic proteins from their biological resources pose a great limitation for industrial manufacturing of biologics in an efficient and cost-effective manner. We report here a supramolecular polymeric system that
Autor:
Margarita Herrera-Alonso, Hanying Luo, Ying Liu, Honggang Cui, Magdalena Szymusiak, Lye Lin Lock, Elena Alexandra Garcia
Publikováno v:
Macromolecules. 50:2201-2206
We describe the use of an amphiphilic macromolecular brush based on poly(ethylene glycol) (PEG) and poly(d,l-lactide) (PLA) as a stabilizer of hydrophobic solutes. The brush, which in solution adopted an extended backbone conformation consequent with
Autor:
Lye Lin Lock, Wang Ma, Yuguo Li, Guanshu Liu, Yi Li, Hanwei Chen, Ran Lin, Xinpei Mao, Verena Staedtke, Honggang Cui, Renyuan Bai
Publikováno v:
ACS Nano. 11:797-805
Gadolinium (Gd)-based compounds and materials are the most commonly used magnetic resonance imaging (MRI) contrast agents in the clinic; however, safety concerns associated with their toxicities in the free ionic form have promoted the development of
Autor:
Lye Lin Lock, Zheng Jian Li, Yuzhu Wang, Arne Schön, Shih Hao Ou, Sanchayita Ghose, Xuankuo Xu, David Stern, Ernesto Freire, Yi Li, Honggang Cui
Publikováno v:
Biomaterials. 178
Many one-dimensional (1D) nanostructures are constructed by self-assembly of peptides or peptide conjugates containing a short β-sheet sequence as the core building motif essential for the intermolecular hydrogen bonding that promotes directional, a
Autor:
Zheng Jian Li, Norman J. Wagner, Sanchayita Ghose, Jing Guo, Xuankuo Xu, Nripen Singh, Kelvin H. Lee, Abraham M. Lenhoff, Leila H. Choe, Steven J. Traylor, Lye Lin Lock, Shannon Modla, Daniel G. Greene
Publikováno v:
Biotechnology and Bioengineering
Protein precipitates that arise during bioprocessing can cause manufacturing challenges, but they can also aid in clearance of host-cell protein (HCP) and DNA impurities. Such precipitates differ from many protein precipitates that have been studied
Publikováno v:
ACS Macro Letters. 4:552-555
We report here on the use of anticancer drug doxorubicin (Dox) to construct a Förster resonance energy transfer (FRET)-based theranostic molecular probe by covalently linking together through a lysine junction a fluorescent drug, a black hole quench
Autor:
Siti M. Janib, Martha K. Pastuszka, J. Andrew MacKay, Lye Lin Lock, Honggang Cui, Xiangdong Wang, Laurie D. DeLeve
Publikováno v:
Journal of Controlled Release. 191:15-23
L4F, an alpha helical peptide inspired by the lipid-binding domain of the ApoA1 protein, has potential applications in the reduction of inflammation involved with cardiovascular disease as well as an antioxidant effect that inhibits liver fibrosis. I
Autor:
Honggang Cui, Francis S. Markland, Martha K. Pastuszka, Stephen Swenson, J. Andrew MacKay, Siti M. Janib, Peter S. Conti, Radu O. Minea, Lye Lin Lock, Zibo Li, Joshua A. Gustafson, Shuanglong Liu
Publikováno v:
Biomacromolecules
Recombinant protein therapeutics have increased in number and frequency since the introduction of human insulin, 25 years ago. Presently, proteins and peptides are commonly used in the clinic. However, the incorporation of peptides into clinically ap
Publikováno v:
Molecular Pharmaceutics
Conjugation with a cell penetrating peptide such as Tat presents an effective approach to improve the intracellular accumulation of molecules with low membrane permeability. This strategy, however, leads to a reduced cellular entry of molecules that