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CGP 57148, a Tyrosine Kinase Inhibitor, Inhibits the Growth of Cells Expressing BCR-ABL, TEL-ABL, and TEL-PDGFR Fusion Proteins

Autor: Carroll, M., Ohno-Jones, S., Tamura, S., Buchdunger, E., Zimmermann, J., Lydon, N. B., Gilliland, D. G., Brian Druker

Publikováno v: Scopus-Elsevier

CGP 57148 is a compound of the 2-phenylaminopyrimidine class that selectively inhibits the tyrosine kinase activity of the ABL and the platelet-derived growth factor receptor (PDGFR) protein tyrosine kinases. We previously showed that CGP 57148 selec

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af9d49795e348f6b0d7cabce78b78095
https://doi.org/10.1182/blood.v90.12.4947

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Akademický článek

Expression and partial characterization of rat protein kinase C-δ and protein kinase C-ξ in insect cells using recombinant baculovirus.

Autor: McGlynn, E., Liebetanz, J., Reutener, S., Wood, J., Lydon, N. B., Hofstetter, H., Vanek, M., Meyer, T., Fabbro, D.

Publikováno v: Journal of Cellular Biochemistry; Jul1992, Vol. 49 Issue 3, p239-250, 12p

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Periodical

Abl protein-tyrosine kinase inhibitor STI571 inhibits in vitro signal transduction mediated by c-kit and platelet-derived growth factor receptors.

Autor: E, Buchdunger, L, Cioffi C, N, Law, D, Stover, S, Ohno-Jones, J, Druker B, B, Lydon N

Publikováno v: The Journal of Pharmacology and Experimental Therapeutics; October 2000, Vol. 295 Issue: 1 p139-45, 7p

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Periodical

Phenylamino-pyrimidine (PAP) derivatives: a new class of potent and highly selective PDGF-receptor autophosphorylation inhibitors

Autor: Zimmermann, J., Buchdunger, E., Mett, H., Meyer, T., Lydon, N. B., Traxler, P.

Publikováno v: Bioorganic & Medicinal Chemistry Letters; 1996, Vol. 6 Issue: 11 p1221-1226, 6p

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Periodical

Use of a Pharmacophore Model for the Design of EGF-R Tyrosine Kinase Inhibitors: 4-(Phenylamino)pyrazolo[3,4-d]pyrimidines

Autor: Traxler, P., Bold, G., Frei, J., Lang, M., Lydon, N., Mett, H., Buchdunger, E., Meyer, T., Mueller, M., Furet, P.

Publikováno v: Journal of Medicinal Chemistry; October 24, 1997, Vol. 40 Issue: 22 p3601-3616, 16p

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Periodical

4-(Phenylamino)pyrrolopyrimidines: Potent and Selective, ATP Site Directed Inhibitors of the EGF-Receptor Protein Tyrosine Kinase

Autor: Traxler, P. M., Furet, P., Mett, H., Buchdunger, E., Meyer, T., Lydon, N.

Publikováno v: Journal of Medicinal Chemistry; June 7, 1996, Vol. 39 Issue: 12 p2285-2292, 8p

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Periodical

Thiazolidine-diones. Biochemical and biological activity of a novel class of tyrosine protein kinase inhibitors.

Autor: Geissler, J F, Traxler, P, Regenass, U, Murray, B J, Roesel, J L, Meyer, T, McGlynn, E, Storni, A, Lydon, N B

Publikováno v: Journal of Biological Chemistry; December 1990, Vol. 265 Issue: 36 p22255-22261, 7p

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Periodical

Cdc2-mediated modulation of pp60c-src activity.

Autor: Stover, D R, Liebetanz, J, Lydon, N B

Publikováno v: Journal of Biological Chemistry; October 1994, Vol. 269 Issue: 43 p26885-26889, 5p

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