Výsledky vyhledávání - "Lydia W.T. Cheung"

Akademický článek

A Three-Way Combinatorial CRISPR Screen for Analyzing Interactions among Druggable Targets

Publikováno v: Cell Reports, Vol 32, Iss 6, Pp 108020- (2020)

Summary: We present a CRISPR-based multi-gene knockout screening system and toolkits for extensible assembly of barcoded high-order combinatorial guide RNA libraries en masse. We apply this system for systematically identifying not only pairwise but

Externí odkaz: https://doaj.org/article/24174da9c12342599b0cf0c61b4eb1cd

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Interview with Dr. Cheung from High Frequency of PIK3R1 and PIK3R2 Mutations in Endometrial Cancer Elucidates a Novel Mechanism for Regulation of PTEN Protein Stability

Autor: Gordon B. Mills, Russell R. Broaddus, Karen H. Lu, Han Liang, Steven E. Scherer, Lewis C. Cantley, Zhenlin Ju, Fan Zhang, Mary D. Dyer, Katherine Stemke-Hale, Yiling Lu, Bojana Djordjevic, Andrea P. Myers, Shuangxing Yu, Jie Li, Bryan T. Hennessy, Lydia W.T. Cheung

mp3 file (7.5 MB). In the July edition of the Cancer Discovery podcast, Executive Editor Judy Quong talks with Lydia W.T. Cheung about her paper on the characterization of genetic mutations found in endometrial cancer.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::43eb10cfc33f864638b97df959478ba5
https://doi.org/10.1158/2159-8290.22529295.v1

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Supplementary Tables 1-3 from High Frequency of PIK3R1 and PIK3R2 Mutations in Endometrial Cancer Elucidates a Novel Mechanism for Regulation of PTEN Protein Stability

Supplementary Tables 1-3 from High Frequency of PIK3R1 and PIK3R2 Mutations in Endometrial Cancer Elucidates a Novel Mechanism for Regulation of PTEN Protein Stability

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d00e0db9bc5b4c0fc35d7564d7dd2bc
https://doi.org/10.1158/2159-8290.22529283.v1

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Supplementary Figures 1-6 from High Frequency of PIK3R1 and PIK3R2 Mutations in Endometrial Cancer Elucidates a Novel Mechanism for Regulation of PTEN Protein Stability

Supplementary Figures 1-6 from High Frequency of PIK3R1 and PIK3R2 Mutations in Endometrial Cancer Elucidates a Novel Mechanism for Regulation of PTEN Protein Stability

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a4fd389eb69a88f63e046c775df6a30
https://doi.org/10.1158/2159-8290.22529289

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Supplementary Figure Legends 1-6 from High Frequency of PIK3R1 and PIK3R2 Mutations in Endometrial Cancer Elucidates a Novel Mechanism for Regulation of PTEN Protein Stability

Supplementary Figure Legends 1-6 from High Frequency of PIK3R1 and PIK3R2 Mutations in Endometrial Cancer Elucidates a Novel Mechanism for Regulation of PTEN Protein Stability

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b4e0c3dee2e17e5f4c10406c8e97a97
https://doi.org/10.1158/2159-8290.22529292.v1

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Supplementary Materials and Methods from High Frequency of PIK3R1 and PIK3R2 Mutations in Endometrial Cancer Elucidates a Novel Mechanism for Regulation of PTEN Protein Stability

Supplementary Materials and Methods from High Frequency of PIK3R1 and PIK3R2 Mutations in Endometrial Cancer Elucidates a Novel Mechanism for Regulation of PTEN Protein Stability

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::131b20043eccc129d2ac8cd565128a21
https://doi.org/10.1158/2159-8290.22529286.v1

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p85β alters response to EGFR inhibitor in ovarian cancer through p38 MAPK-mediated regulation of DNA repair

Autor: Victor Cy Mak, Ling Rao, Yuan Zhou, Xinran Li, Lydia W.T. Cheung, Sai Wah Tsao

Publikováno v: Neoplasia: An International Journal for Oncology Research, Vol 23, Iss 7, Pp 718-730 (2021)
Neoplasia (New York, N.Y.)

EGFR signaling promotes ovarian cancer tumorigenesis, and high EGFR expression correlates with poor prognosis. However, EGFR inhibitors alone have demonstrated limited clinical benefit for ovarian cancer patients, owing partly to tumor resistance and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67ecad4c612d528a8bee41b800d44cef
http://www.sciencedirect.com/science/article/pii/S1476558621000348

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The impact of the multi-disciplinary molecular tumour board and integrative next generation sequencing on clinical outcomes in advanced solid tumours

Autor: Aya El Helali, Tai-Chung Lam, Elaine Yee-Ling Ko, David J.H. Shih, Chun Kau Chan, Charlene H.L. Wong, Jason W.H. Wong, Lydia W.T. Cheung, Johnny K.S. Lau, Anthony P.Y. Liu, Ann S.Y. Chan, Herbert H. Loong, Stephen Tak Sum Lam, Godfrey Chi-Fung Chan, Victor H.F. Lee, Kwok Keung Yuen, Wai-Tong Ng, Anne W.M. Lee, Edmond S.K. Ma

Publikováno v: The Lancet Regional Health - Western Pacific. :100775

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::135e4308351f21f6e42a6467166b4190
https://doi.org/10.1016/j.lanwpc.2023.100775

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Strategic Combination Therapies for Ovarian Cancer

Autor: Lydia W.T. Cheung, Annie N.Y. Cheung, Angel S N Ng, Xinran Li, Victor Cy Mak, Karen K L Chan

Publikováno v: Current Cancer Drug Targets. 20:573-585

Ovarian cancer remains the leading cause of gynecologic cancer-related deaths among women worldwide. The dismal survival rate is partially due to recurrence after standardized debulking surgery and first-line chemotherapy. In recent years, targeted t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::657b58b3bf03147503c3ff28c3118720
https://doi.org/10.2174/1568009620666200511084007

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