Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Lydia W. M. Nausch"'
Autor:
Jessica Wohlfahrt, Thomas M. Moon, Dwight E. Matthews, Wolfgang R. Dostmann, Praveena Nukareddy, Lydia W. M. Nausch, Jessica L. Sheehe, Donald K. Blumenthal
Publikováno v:
Journal of Biological Chemistry. 293:7916-7929
The type I cGMP-dependent protein kinases (PKG I) serve essential physiological functions, including smooth muscle relaxation, cardiac remodeling, and platelet aggregation. These enzymes form homodimers through their N-terminal dimerization domains,
Publikováno v:
Clinical laboratory. 65(6)
With his discovery of the ABO blood group system, Karl Landsteiner laid the foundation for modern day transfusion medicine. This discovery represents the basic knowledge for every blood transfusion. In recent years, certain blood groups have been lin
Autor:
Mark T. Nelson, Michael I. Kotlikoff, Thomas J. Heppner, Adrian D. Bonev, Lydia W. M. Nausch, Yvonne N. Tallini
Publikováno v:
American Journal of Physiology-Heart and Circulatory Physiology. 302:H594-H602
It is generally accepted that the endothelium regulates vascular tone independent of the activity of the sympathetic nervous system. Here, we tested the hypothesis that the activation of sympathetic nerves engages the endothelium to oppose vasoconstr
Publikováno v:
Journal of Molecular Biology
In eukaryotes, the poly(A) tail added at the 3' end of an mRNA precursor is essential for the regulation of mRNA stability and the initiation of translation. Poly(A) polymerase (PAP) is the enzyme that catalyzes the poly(A) addition reaction. Multipl
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 105(1)
Here, we report the design of unprecedented, non-FRET based cGMP-biosensors, named FlincGs, to assess the dynamics of nitric oxide (NO) and atrial natriuretic peptide (ANP) induced synthesis of intracellular cGMP, [cGMP] i . Regulatory fragments of P
Publikováno v:
BMC Pharmacology. 7(Suppl 1):S22
Previously, our lab has developed FRET-based cGMP-indicators (cygnets) to study the spatial and temporal dynamics of intracellular cGMP [1]. Cygnets have been proven to advance our understanding of NO/cGMP signaling in vascular smooth muscle cells [2