Identification of Phenylpyrazolone Dimers as a New Class of Anti-Trypanosoma cruzi Agents

Autor: Louis Maes, Maria de Nazaré Correia Soeiro, Rob Leurs, Alba Ramos Llorca, Geert Jan Sterk, Lydia Stiny, Iwan J. P. de Esch, An Matheeussen, Maarten Sijm, Julianna Siciliano de Araújo, Kristina M. Orrling

Publikováno v: ChemMedChem, 14(18), 1662-1668. John Wiley and Sons Ltd
Sijm, M, Siciliano de Araújo, J, Ramos Llorca, A, Orrling, K, Stiny, L, Matheeussen, A, Maes, L, de Esch, I J P, de Nazaré Correia Soeiro, M, Sterk, G J & Leurs, R 2019, ' Identification of Phenylpyrazolone Dimers as a New Class of Anti-Trypanosoma cruzi Agents ', ChemMedChem, vol. 14, no. 18, pp. 1662-1668 . https://doi.org/10.1002/cmdc.201900370
ChemMedChem
Chemmedchem

Chagas disease is becoming a worldwide problem; it is currently estimated that over six million people are infected. The two drugs in current use, benznidazole and nifurtimox, require long treatment regimens, show limited efficacy in the chronic phas

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https://research.vu.nl/en/publications/0fc16b36-d48a-4130-af08-17e6014afc5f