MRZ-99030 - A novel modulator of Aβ aggregation: II - Reversal of Aβ oligomer-induced deficits in long-term potentiation (LTP) and cognitive performance in rats and mice

Autor: Maarten Ruitenberg, Eun-Mee Kim, Eugene O'Hare, Kamila Sroka-Saidi, Nico Wegener, David Spanswick, Wolfgang Georg Bywalez, Chris G. Parsons, Gerhard Rammes, Veronica Egger, Lydia Staniaszek, Andreas Gravius, Caroline Chambon, Ross Jeggo, Philip Palmer

Publikováno v: Neuropharmacology
Neuropharmacology, Elsevier, 2015, ⟨10.1016/j.neuropharm.2014.12.037⟩
Neuropharmacology, 2015, ⟨10.1016/j.neuropharm.2014.12.037⟩

International audience; β-amyloid1-42 (Aβ1-42) is a major endogenous pathogen underlying the aetiology of Alzheimer's disease (AD). Recent evidence indicates that soluble Aβ oligomers, rather than plaques, are the major cause of synaptic dysfuncti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a4dbd730deb5252bf4be705ecd33ad8
https://hal-amu.archives-ouvertes.fr/hal-01441749