Real-time monitoring of replication errors’ fate reveals the origin and dynamics of spontaneous mutations

Autor: Chiara Enrico Bena, Jean Ollion, Marianne De Paepe, Magali Ventroux, Lydia Robert, Marina Elez

Publikováno v: Nature Communications, Vol 15, Iss 1, Pp 1-11 (2024)

Abstract The efficiency of replication error repair is a critical factor governing the emergence of mutations. However, it has so far been impossible to study this efficiency at the level of individual cells and to investigate if it varies within iso

Externí odkaz: https://doaj.org/article/f6aaeafaa6b1488da04bdee4be66d124

Emergence of variability in isogenic Escherichia coli populations infected by a filamentous virus.

Autor: Marianne De Paepe, Silvia De Monte, Lydia Robert, Ariel B Lindner, François Taddei

Publikováno v: PLoS ONE, Vol 5, Iss 7, p e11823 (2010)

The spread of epidemics not only depends on the average number of parasites produced per host, but also on the existence of highly infectious individuals. It is widely accepted that infectiousness depends on genetic and environmental determinants. Ho

Externí odkaz: https://doaj.org/article/a4ecfe4aff4f403aa34580fd02c57efa

Extrinsic noise prevents the independent tuning of gene expression noise and protein mean abundance in bacteria

Autor: Jérôme Robert, Stéphane Aymerich, Lydia Robert, Matthieu Jules, A. Deloupy, Vincent Sauveplane

Publikováno v: Science Advances
Biochem. (Life Sci. Adv.)
Biochem. (Life Sci. Adv.), 2020, 6 (41), pp.eabc3478. ⟨10.1126/sciadv.abc3478⟩

Gene expression noise cannot be tuned independently of protein mean abundance for most bacterial genes.
It is generally accepted that prokaryotes can tune gene expression noise independently of protein mean abundance by varying the relative leve

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a63eaa72120d606fad56cd5a5bc52491
http://europepmc.org/articles/PMC7541070

Estimating the division rate from indirect measurements of single cells

Autor: Lydia Robert, Adélaïde Olivier, Marie Doumic

Publikováno v: Discrete and Continuous Dynamical Systems-Series B
Discrete and Continuous Dynamical Systems-Series B, 2020, 25 (10), pp.3931--3961. ⟨10.3934/dcdsb.2020078⟩
Discrete and Continuous Dynamical Systems-Series B, American Institute of Mathematical Sciences, 2020, 25 (10), pp.3931--3961. ⟨10.3934/dcdsb.2020078⟩

International audience; Is it possible to estimate the dependence of a growing and dividing population on a given trait in the case where this trait is not directly accessible by experimental measurements, but making use of measurements of another va

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::81682c321236d28144b68f7349fa9de9
https://hal.archives-ouvertes.fr/hal-02175633/file/Adder_model.pdf

Method for Detecting and Studying Genome-Wide Mutations in Single Living Cells in Real Time

Autor: Marina, Elez, Lydia, Robert, Ivan, Matic

Publikováno v: Methods in molecular biology (Clifton, N.J.). 1736

DNA sequencing and fluctuation test have been choice methods for studying DNA mutations for decades. Although invaluable tools allowing many important discoveries on mutations, they are both highly influenced by fitness effects of mutations, and ther

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::4f16e08c5080437c022af1eebdd14a10
https://pubmed.ncbi.nlm.nih.gov/29322456