Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Lydia Raines"'
Autor:
Alexander Medvedev, Matt Moeser, Liubov Medvedeva, Elena Martsen, Alexander Granick, Lydia Raines, Kristen Gorman, Benjamin Lin, Ming Zeng, Keith A. Houck, Sergei S. Makarov
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-18 (2022)
Abstract Nuclear receptors (NR) are ligand-modulated transcription factors that regulate multiple cell functions and thus represent excellent drug targets. However, due to a considerable NR structural homology, NR ligands often interact with multiple
Externí odkaz:
https://doaj.org/article/7b4fcb73a0c54a51a995d71c913737bf
Autor:
Naoya Uchida, Matthew M. Hsieh, Lydia Raines, Juan J. Haro-Mora, Selami Demirci, Aylin C. Bonifacino, Allen E. Krouse, Mark E. Metzger, Robert E. Donahue, John F. Tisdale
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
Vectors used in gene therapy for hemoglobin disorders carry globin in a reverse-orientation to prevent the loss of key regulatory elements by RNA splicing, but this limits their efficiency. Here, the authors develop a vector carrying β-globin in a f
Externí odkaz:
https://doaj.org/article/10b9f0823d304489858931b8d82f9d3e
Autor:
Naoya Uchida, R Patrick Weitzel, Anna Shvygin, Luke P Skala, Lydia Raines, Aylin C Bonifacino, Allen E Krouse, Mark E Metzger, Robert E Donahue, John F Tisdale
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 3, Iss C (2016)
Reduced intensity conditioning (RIC) is desirable for hematopoietic stem cell (HSC) gene therapy applications. However, low gene marking was previously observed in gene therapy trials, suggesting that RIC might be insufficient for (i) opening niches
Externí odkaz:
https://doaj.org/article/b2866a0cb9114dddbfe8675ea28d0e4a
Autor:
Alexander Medvedev, Ming Zeng, Kristen L Gorman, Alexander Granick, Sergei S. Makarov, Benjamin Lin, Lydia Raines, Keith A. Houck, Elena Martsen, Matthew Moeser, Liubov Medvedeva
Nuclear receptors (NR) are ligand-modulated transcription factors that regulate multiple cell functions and thus represent excellent drug targets. However, due to a considerable NR structural homology, NR ligands often interact with multiple receptor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6cf091b36876badb30b5f1f020b69d6b
https://doi.org/10.21203/rs.3.rs-478112/v1
https://doi.org/10.21203/rs.3.rs-478112/v1
Autor:
Alexander Medvedev, Keith A. Houck, Alexander Granick, Sergei Makarov, Ming Zeng, Lydia Raines, Elena Martsen, Sergei S. Makarov, Liubov Medvedeva, Matt Moeser
Publikováno v:
Science Advances. 4
Assessing the biological activity of compounds is an essential objective of biomedical research. We show that one can infer the bioactivity of compounds by assessing the activity of transcription factors (TFs) that regulate gene expression. Using a m