Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Lydia P. Liew"'
Autor:
Lydia P. Liew, Avik Shome, Way W. Wong, Cho R. Hong, Kevin O. Hicks, Stephen M. F. Jamieson, Michael P. Hay
Publikováno v:
Molecules, Vol 28, Iss 11, p 4457 (2023)
The role of hypoxic tumour cells in resistance to radiotherapy, and in suppression of immune response, continues to endorse tumour hypoxia as a bona fide, yet largely untapped, drug target. Radiotherapy innovations such as stereotactic body radiother
Externí odkaz:
https://doaj.org/article/4764aa3eb15346ccaeda89c53387ec2a
Autor:
Wei W. Teo, Lian K. Ti, Lyn L. Lean, Edwin Seet, Ambika Paramasivan, Weiling Liu, Jiexun Wang, Vanessa Chua, Lydia Q. Liew
Publikováno v:
BMC Surgery, Vol 20, Iss 1, Pp 1-7 (2020)
Abstract Background Diabetes is known to increase morbidity and 30-day mortality in adults undergoing non-cardiac surgery, but longer term outcomes are less studied. This study was done to explore how undiagnosed and known diabetes affect 30-day and
Externí odkaz:
https://doaj.org/article/1f4ff9f0694a4f2888df59b3c277351c
Autor:
Hay, Lydia P. Liew, Avik Shome, Way W. Wong, Cho R. Hong, Kevin O. Hicks, Stephen M. F. Jamieson, Michael P.
Publikováno v:
Molecules; Volume 28; Issue 11; Pages: 4457
The role of hypoxic tumour cells in resistance to radiotherapy, and in suppression of immune response, continues to endorse tumour hypoxia as a bona fide, yet largely untapped, drug target. Radiotherapy innovations such as stereotactic body radiother
Publikováno v:
Clinical Oncology. 31:290-302
The role of hypoxia in radiation resistance is well established and many approaches to overcome hypoxia in tumours have been explored, with variable success. Two small molecule strategies for targeting hypoxia have dominated preclinical and clinical
Autor:
Dean C. Singleton, Lydia P. Liew, Stephen M. F. Jamieson, Michael P. Hay, Way W. Wong, Gary J. Cheng
Publikováno v:
Chemistry – An Asian Journal. 14:1238-1248
Tumour hypoxia plays an important role in tumour progression and resistance to therapy. Under hypoxia unfolded proteins accumulate in the endoplasmic reticulum (ER) and this stress is relieved through the protein kinase R-like ER kinase (PERK) signal
Autor:
Nicole Prodan, Michael P. Hay, Keith Richards, Roxana Maria Rujan, Rebekah L. Bower, Debbie L. Hay, Augen A. Pioszak, Risha Sudra, Erica R. Hendrikse, Muhammad A. Jamaluddin, Christopher S. Walker, Muriel Bonnet, Jack U. Flanagan, Lydia P. Liew, David M. Smith, Garry Pairaudeau, Jason M. Booe, Christopher A. Reynolds
Publikováno v:
ACS Pharmacol Transl Sci
[Image: see text] Class B G protein-coupled receptors are highly therapeutically relevant but challenges remain in identifying suitable small-molecule drugs. The calcitonin-like receptor (CLR) in particular is linked to conditions such as migraine, c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2cad1eccc07505f73ff6ab7e3e92e43f
https://europepmc.org/articles/PMC7155196/
https://europepmc.org/articles/PMC7155196/
Autor:
William R. Wilson, Ralph J. Stevenson, Cho R. Hong, Stephen M. F. Jamieson, Wen Qi, Avik Shome, Yongchuan Gu, Robert F. Anderson, Way W. Wong, Muriel Bonnet, Michael P. Hay, Jingli Wang, Kevin O. Hicks, Frederik B. Pruijn, Lydia P. Liew
Publikováno v:
Journal of Medicinal Chemistry. 61:1241-1254
Innovations in the field of radiotherapy such as stereotactic body radiotherapy, along with the advent of radio-immuno-oncology, herald new opportunities for classical oxygen-mimetic radiosensitizers. The role of hypoxic tumor cells in resistance to
Autor:
William R. Wilson, Michael P. Hay, Benjamin D. Dickson, Gary J. Cheng, Francis W. Hunter, Barbara Lipert, Lydia P. Liew, Rosanna K. Jackson, Yongchuan Gu, Way W. Wong
Publikováno v:
Biochemical pharmacology. 169
DNA-dependent protein kinase (DNA-PK) plays a key role in repair of radiation-induced DNA double strand breaks (DSB) by non-homologous end-joining. DNA-PK inhibitors (DNA-PKi) are therefore efficient radiosensitisers, but normal tissue radiosensitisa
Autor:
Michael P. Hay, Robert Tibshirani, Mark G. Moloney, Joshua Bloomstein, Dadi Jiang, Peter S. Lu, Brandon E. Turner, Lydia P. Liew, Quynh-Thu Le, Albert C. Koong, Purvesh Khatri, William Yuan, Dhanya Nambiar
Publikováno v:
Journal of chemical information and modeling. 57(4)
We describe a new library generation method, Machine-based Identification of Molecules Inside Characterized Space (MIMICS), that generates sets of molecules inspired by a text-based input. MIMICS-generated libraries were found to preserve distributio
Publikováno v:
European Journal of Medicinal Chemistry. 69:22-31
We recently reported that 1,14-diphenylacetamide derivatives of spermine exhibit potent nM in vitro growth inhibition properties of Plasmodium falciparum. In an effort to expand the structure-activity relationship of this compound class towards malar