Výsledky vyhledávání - "Lydia O'Neill"

Expression Of aquaporin-1 (AQP-1) in rat heart

Autor: Jing-Sheng Zheng, Xilin Long, Michael T. Crow, Marvin O. Boluyt, Lydia O'Neill, W. J. Lederer, Yanshan Dai, Zhihe Li, Jun Li, Edward G. Lakatta, Bruce J. Baum, Heping Cheng

Publikováno v: The Asia Pacific Heart Journal. 8:36-43

Background. AQP-1, a channel-forming integral membrane protein of 28 kDa prevalent in red blood cells and renal proximal tubules, was recently shown to be expressed in rat heart. Aims : Our purpose was to charaterise the experssion of the AQO-1 gene

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::14027910dfab6afc8393afb301e04510
https://doi.org/10.1016/s1328-0163(99)90007-6

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Myocardial Retinoid X Receptor, Thyroid Hormone Receptor, and Myosin Heavy Chain Gene Expression in the Rat During Adult Aging

Autor: Marvin O. Boluyt, Jing Sheng Zheng, Edward G. Lakatta, Lydia O'Neill, Guimei Wu, Xilin Long, Michael T. Crow, Yu Ko Nitta

Publikováno v: The Journals of Gerontology Series A: Biological Sciences and Medical Sciences. 54:B23-B27

Although previous studies have shown that cardiac myosin heavy chain (MHC) composition undergoes a switch from the alpha- to beta-isoform in the heart during adult aging, the underlying mechanisms responsible for this switch are unknown. Cardiac MHC

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f4834e8263c93cc2637d5c1b3a04039b
https://doi.org/10.1093/gerona/54.1.b23

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Stimulation of P2Y receptors activates c-fos gene expression and inhibits DNA synthesis in cultured cardiac fibroblasts

Autor: Marvin O. Boluyt, Edward G. Lakatta, Tania E. Webb, Lydia O'Neill, Eric A. Barnard, Jing Sheng Zheng, Xilin Long

Publikováno v: Cardiovascular Research. 37:718-728

Objectives: The aims of this study were to determine (1) whether neonatal rat cardiac fibroblasts (CAFB) express P2Y receptors; (2) whether CAFB respond to extracellular ATP by inducing expression of c-fos mRNA; and (3) whether extracellular ATP modu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ecdae8573995219ceb54adf06d87b42
https://doi.org/10.1016/s0008-6363(97)00245-9

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Rapamycin Inhibits α 1 -Adrenergic Receptor–Stimulated Cardiac Myocyte Hypertrophy but Not Activation of Hypertrophy-Associated Genes

Autor: Antoine Younes, Howard S. Silverman, Jing Sheng Zheng, Michael T. Crow, Lydia O'Neill, Xilin Long, Marvin O. Boluyt, Edward G. Lakatta

Publikováno v: Circulation Research. 81:176-186

Abstract The 70-kD S6 kinase (p70 S6K ) has been implicated in the regulation of protein synthesis in many cell types and in the angiotensin II–stimulated hypertrophy of cardiac myocytes. Our purpose was to determine whether p70 S6K plays a role in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ddf34b64b9bfe8fce5ab0b076fec048a
https://doi.org/10.1161/01.res.81.2.176

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p53 and the hypoxia-induced apoptosis of cultured neonatal rat cardiac myocytes

Autor: Edward G. Lakatta, Maria De Lourdes Hipolito, Marvin O. Boluyt, Jing Sheng Zheng, Lydia O'Neill, Martha S. Lundberg, Corrado Cirielli, Xilin Long, Michael T. Crow

Publikováno v: Journal of Clinical Investigation. 99:2635-2643

Myocyte cell loss is a prominent and important pathogenic feature of cardiac ischemia. We have used cultured neonatal rat cardiac myocytes exposed to prolonged hypoxia as an experimental system to identify critical factors involved in cardiomyocyte d

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa95aaf011b3668ffb32c3289997ca9f
https://doi.org/10.1172/jci119452

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Age-associated increase in rat ventricular ANP gene expression correlates with cardiac hypertrophy

Autor: Marvin O. Boluyt, Antoine Younes, Andrea L. Meredith, Edward G. Lakatta, Lydia O'Neill, Michael T. Crow

Publikováno v: American Journal of Physiology-Heart and Circulatory Physiology. 269:H1003-H1008

Atrial natriuretic peptide (ANP), a cardiac-specific hormone, is stored in the atria and released in response to atrial stretch. During cardiac hypertrophy, ANP gene expression is markedly upregulated in the left ventricle (LV). Because the hearts of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62b941fa637426bbde8a69c21234e135
https://doi.org/10.1152/ajpheart.1995.269.3.h1003

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Alterations in cardiac gene expression during the transition from stable hypertrophy to heart failure. Marked upregulation of genes encoding extracellular matrix components

Autor: Chester H. Conrad, Michael T. Crow, Marvin O. Boluyt, O. H. L. Bing, Edward G. Lakatta, Lydia O'Neill, Andrea L. Meredith, Wesley W. Brooks

Publikováno v: Circulation Research. 75:23-32

The failing heart is characterized by impaired cardiac muscle function and increased interstitial fibrosis. Our purpose was to determine whether the functional impairment of the failing heart is associated with changes in levels of mRNA encoding prot

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d0e50b36955f83927a122ecca2a65a9
https://doi.org/10.1161/01.res.75.1.23

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Age-associated increase in rat cardiac opioid production

Autor: J. L. Caffrey, Antoine Younes, Edward G. Lakatta, Lydia O'Neill, B. A. Barron, Marvin O. Boluyt, Michael T. Crow

Publikováno v: American Journal of Physiology-Heart and Circulatory Physiology. 265:H212-H218

Several lines of evidence suggest that opioid peptide production in the heart may increase during aging from adulthood through senescence. We tested the hypothesis that cardiac opioid peptides and preproenkephalin (PNK) mRNA would increase with advan

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::caff290845eff554c04ea1112c693a61
https://doi.org/10.1152/ajpheart.1993.265.1.h212

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