Výsledky vyhledávání - "Lydia Melissourgou-Syka"

Akademický článek

A Review of Scheduling Strategies for Radiotherapy and Immune Checkpoint Inhibition in Locally Advanced Rectal Cancer

Autor: Lydia Melissourgou-Syka, Michael A. Gillespie, Sean M. O'Cathail, Owen J. Sansom, Colin W. Steele, Campbell S. D. Roxburgh

Publikováno v: Journal of Immunotherapy and Precision Oncology, Vol 6, Iss 4, Pp 187-197 (2023)

Colorectal cancer (CRC) is the third most common malignancy across the globe and, despite advances in treatment strategies, survival rates remain low. Rectal cancer (RC) accounts for most of these cases, and traditional management strategies for adva

Externí odkaz: https://doaj.org/article/8489cce57d0f48d292b136f85aaed0f1

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Spatially Resolved Transcriptomics Deconvolutes Prognostic Histological Subgroups in Patients with Colorectal Cancer and Synchronous Liver Metastases

Autor: Colin S. Wood, Kathryn A.F. Pennel, Holly Leslie, Assya Legrini, Andrew J. Cameron, Lydia Melissourgou-Syka, Jean A. Quinn, Hester C. van Wyk, Jennifer Hay, Antonia K. Roseweir, Colin Nixon, Campbell S.D. Roxburgh, Donald C. McMillan, Andrew V. Biankin, Owen J. Sansom, Paul G. Horgan, Joanne Edwards, Colin W. Steele, Nigel B. Jamieson

Publikováno v: Cancer Research. 83:1329-1344

Strong immune responses in primary colorectal cancer correspond with better patient survival following surgery compared with tumors with predominantly stromal microenvironments. However, biomarkers to identify patients with colorectal cancer liver me

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::774945f4abcfa2bf86be777d51c0e348
https://doi.org/10.1158/0008-5472.can-22-2794

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Supplementary Data from Spatially Resolved Transcriptomics Deconvolutes Prognostic Histological Subgroups in Patients with Colorectal Cancer and Synchronous Liver Metastases

Autor: Nigel B. Jamieson, Colin W. Steele, Joanne Edwards, Paul G. Horgan, Owen J. Sansom, Andrew V. Biankin, Donald C. McMillan, Campbell S.D. Roxburgh, Colin Nixon, Antonia K. Roseweir, Jennifer Hay, Hester C. van Wyk, Jean A. Quinn, Lydia Melissourgou-Syka, Andrew J. Cameron, Assya Legrini, Holly Leslie, Kathryn A.F. Pennel, Colin S. Wood

All supplementary figures and supplementary tables 1 and 2 from the manuscript

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::403e64c8ec0da6f59bb48f6e55065ecc
https://doi.org/10.1158/0008-5472.22633296.v1

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Supplementry Table 3: REACTOME Gene Set Enrichment Analysis results from Spatially Resolved Transcriptomics Deconvolutes Prognostic Histological Subgroups in Patients with Colorectal Cancer and Synchronous Liver Metastases

Gene Set Enrichment Analysis results obtained by interrogating ranked list of differentially expressed KM high vs KM low genes against the REACTOME curated gene set database using ClusterProfiler package

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::52eb2629c57087ccdf7531fa25bf1bf6
https://doi.org/10.1158/0008-5472.22633287.v1

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Supplementary Methods from Spatially Resolved Transcriptomics Deconvolutes Prognostic Histological Subgroups in Patients with Colorectal Cancer and Synchronous Liver Metastases

Supplementary details regarding methods and materials

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c84d91b354ecd603c7bb4d3097c5852
https://doi.org/10.1158/0008-5472.22633293.v1

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Supplementary Table 4: SpatialDecon derived immune cell counts from Spatially Resolved Transcriptomics Deconvolutes Prognostic Histological Subgroups in Patients with Colorectal Cancer and Synchronous Liver Metastases

SpatialDecon derived immune cell counts aggregated by Region, KM grade and KRAS status with pairwise comparison between groups. Mann-Whitney test used to determine statistical significance between groups

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58adec63ac2802bd346cb81495e87314
https://doi.org/10.1158/0008-5472.22633290

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Data from Spatially Resolved Transcriptomics Deconvolutes Prognostic Histological Subgroups in Patients with Colorectal Cancer and Synchronous Liver Metastases

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f0623b1dd2a51eb627cb56e66bac841
https://doi.org/10.1158/0008-5472.c.6599682.v1

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Spatially Resolved Transcriptomics Deconvolutes Histological Prognostic Subgroups in Patients with Colorectal Cancer and Synchronous Liver Metastases

Autor: Colin S Wood, Kathryn AF Pennel, Holly Leslie, Assya Legrini, Andrew J Cameron, Lydia Melissourgou-Syka, Jean A Quinn, Hester C van Wyk, Jennifer Hay, Antonia K Roseweir, Colin Nixon, Campbell SD Roxburgh, Donald C McMillan, Andrew V Biankin, Owen J Sansom, Paul G Horgan, Joanne Edwards, Colin W Steele, Nigel B Jamieson

BackgroundPatients demonstrating strong immune responses to primary colorectal cancer (CRC) have a survival benefit following surgery, while those with predominantly stromal microenvironments do poorly. Biomarkers to identify patients with colorectal

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0c8fc92f58d773ceeffcae3fb4890683
https://doi.org/10.1101/2022.09.21.508569

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Spatially resolved transcriptomics deconvolutes histological prognostic subgroups in patients with colorectal cancer and synchronous liver metastases

Autor: Colin Wood, Holly Leslie, Assya Legrini, Lydia Melissourgou-Syka, Kathryn AF Pennel, Joanne Edwards, Colin William Steele, Nigel Balfour Jamieson

Publikováno v: Journal of Clinical Oncology. 40:165-165

165 Background: Up to 50% of patients with Colorectal Cancer (CRC) will metastasise to the liver (CRLM). KRAS-mt liver metastases particularly when co-mutated with TP53 are associated with poor prognosis. We have used the Glasgow Microenvironment Sco

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::05b36e3dceb0c2b57ee3d4d4ff55d8af
https://doi.org/10.1200/jco.2022.40.4_suppl.165

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