Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Lydia Mata"'
Autor:
Maria Penzo, Laura de las Heras-Dueña, Lydia Mata-Cantero, Beatriz Diaz-Hernandez, Maria-Jesus Vazquez-Muñiz, Sonja Ghidelli-Disse, Gerard Drewes, Elena Fernandez-Alvaro, David A. Baker
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-13 (2019)
Abstract Antimalarial drug resistance compels the quest for new compounds that target alternative pathways to current drugs. The Plasmodium cyclic GMP-dependent protein kinase (PKG) has essential functions in all of the major life cycle developmental
Externí odkaz:
https://doaj.org/article/7b1853796974419994e20d37569169f5
Autor:
Raquel Vida Fernández, Maria G. Gomez-Lorenzo, Stanley C. Xie, Francisco-Javier Gamo, Esther Fernández, David L. Gillett, Joanne Coyle, Alvaro Cortes Cabrera, Mercedes García, Benigno Crespo, Leann Tilley, Lydia Mata-Cantero
Publikováno v:
ACS infectious diseases. 7(6)
The Ubiquitin Proteasome System is the main proteolytic pathway in eukaryotic cells, playing a role in key cellular processes. The essentiality of the Plasmodium falciparum proteasome is well validated, underlying its potential as an antimalarial tar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d66aa856f50b54b5c3f742cdf12cd854
https://pubmed.ncbi.nlm.nih.gov/34044540
https://pubmed.ncbi.nlm.nih.gov/34044540
Autor:
Maria G. Gomez-Lorenzo, Concepción Cid, Gonzalo Colmenarejo, María J. Chaparro, Alvaro Cortes Cabrera, Lydia Mata-Cantero, Francisco-Javier Gamo, Julio Martin, Manuel S. Rodriguez
Publikováno v:
ACS Infectious Diseases
ACS Infectious Diseases, American Chemical Society, 2019, 5 (12), pp.2105-2117. ⟨10.1021/acsinfecdis.9b00216⟩
ACS Infectious Diseases, American Chemical Society, 2019, 5 (12), pp.2105-2117. ⟨10.1021/acsinfecdis.9b00216⟩
International audience; The ubiquitin proteasome system (UPS) is one of the main proteolytic pathways in eukaryotic cells, playing an essential role in key cellular processes such as cell cycling and signal transduction. Changes in some of the compon
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a263c35e695b9e95e6014370d7bacb8f
https://pubmed.ncbi.nlm.nih.gov/31644867
https://pubmed.ncbi.nlm.nih.gov/31644867
Autor:
Hyungjin Eoh, Harvey Rubin, Yu Min Chuang, Jae Jin Lee, María Jesús Vázquez, Fernando Ramón, Delfina Segura-Carro, Lee G. Klinkenberg, Esther Pérez-Herrán, Lydia Mata-Cantero, Noton K. Dutta, Joel S. Bader, Beatriz Rodriguez-Miquel, Gonzalo Colmenarejo, Alfonso Mendoza-Losana, Petros C. Karakousis, Esther Porras de Francisco
Publikováno v:
Science Advances. 5
The stringent response enables Mycobacterium tuberculosis (Mtb) to shut down its replication and metabolism under various stresses. Here we show that Mtb lacking the stringent response enzyme RelMtb was unable to slow its replication rate during nutr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7e25411e2a876c81259f52c6a3d69dc0
https://doi.org/10.1126/sciadv.aav2104
https://doi.org/10.1126/sciadv.aav2104
Autor:
Ana Guardia, Máire A. Convery, David Calvo, Feng Wang, Joaquín Rullas, Delia Blanco, Julia Castro-Pichel, Lydia Mata, Esther Pérez-Herrán, Robert J. Young, María Santos Martínez, Raquel Vida Fernández, Jesús Roque Campaña Gómez, Lluís Pagès, Gulcin Gulten, Alfonso Mendoza-Losana, Modesto J. Remuiñán, Marta León Alonso, James C. Sacchettini, Fátima Ortega
Publikováno v:
ChemMedChem. 11:687-701
Isoniazid (INH) remains one of the cornerstones of antitubercular chemotherapy for drug-sensitive strains of M. tuberculosis bacteria. However, the increasing prevalence of multidrug-resistant (MDR) and extensively drug-resistant (XDR) strains contai
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15d1d905239441b05fdf10ee9b7585b0
https://doi.org/10.1002/cmdc.201600020
https://doi.org/10.1002/cmdc.201600020
Autor:
Noton K, Dutta, Lee G, Klinkenberg, Maria-Jesus, Vazquez, Delfina, Segura-Carro, Gonzalo, Colmenarejo, Fernando, Ramon, Beatriz, Rodriguez-Miquel, Lydia, Mata-Cantero, Esther, Porras-De Francisco, Yu-Min, Chuang, Harvey, Rubin, Jae Jin, Lee, Hyungjin, Eoh, Joel S, Bader, Esther, Perez-Herran, Alfonso, Mendoza-Losana, Petros C, Karakousis
Publikováno v:
Science Advances
The stringent response enzyme is a promising new target for Mycobacterium tuberculosis persisters.
The stringent response enables Mycobacterium tuberculosis (Mtb) to shut down its replication and metabolism under various stresses. Here we show t
The stringent response enables Mycobacterium tuberculosis (Mtb) to shut down its replication and metabolism under various stresses. Here we show t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::661a90ceb9083dd42487aaa203f2672b
https://pubmed.ncbi.nlm.nih.gov/30906866
https://pubmed.ncbi.nlm.nih.gov/30906866
Publikováno v:
Methods in Molecular Biology ISBN: 9781493937547
Tandem ubiquitin-binding entities (TUBEs) act as molecular traps to isolate polyubiquitylated proteins facilitating the study of this highly reversible posttranslational modification. We provide here sample preparation and adaptations required for TU
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dfceda99b507fedc0807ebccddc43ada
https://doi.org/10.1007/978-1-4939-3756-1_8
https://doi.org/10.1007/978-1-4939-3756-1_8
Autor:
Julio Martin-Plaza, Maria Jose Lafuente, Manuel S. Rodriguez, Rune Matthiesen, Mikel Azkargorta, Fabienne Aillet, Ana Sofia Carvalho, Wendy Xolalpa, Lydia Mata-Cantero, Felix Elortza
Publikováno v:
Journal of proteomics. 139
Malaria, caused by Plasmodium falciparum (P. falciparum), ranks as one of the most baleful infectious diseases worldwide. New antimalarial treatments are needed to face existing or emerging drug resistant strains. Protein degradation appears to play
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::21db38171352f71e7eaf4c996c8895f2
https://pubmed.ncbi.nlm.nih.gov/26972027
https://pubmed.ncbi.nlm.nih.gov/26972027
Autor:
Manuel S. Rodriguez, Julio Martin, Lydia Mata-Cantero, Concepción Cid, Wendy Xolalpa, Maria G. Gomez-Lorenzo, Fabienne Aillet
Publikováno v:
Malaria Journal
Background The ubiquitin proteasome system (UPS) is one of the main proteolytical pathways in eukaryotic cells and plays an essential role in key cellular processes such as cell cycle, stress response, signal transduction, and transcriptional regulat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f30a2e738f5fd91a07a70b897ef0c970
https://pubmed.ncbi.nlm.nih.gov/25968882
https://pubmed.ncbi.nlm.nih.gov/25968882
Publikováno v:
Stress Response Pathways in Cancer ISBN: 9789401794206
The Ubiquitin-Proteasome System (UPS) plays an important role in the setting of the cellular response to multiple stress signals. Although the primary function of ubiquitin was initially associated with proteolysis, it is now considered as a key regu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::06f5c635160ce1f5b0fe7485f6fdb6ed
https://doi.org/10.1007/978-94-017-9421-3_11
https://doi.org/10.1007/978-94-017-9421-3_11