Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Lydia M. Roberts"'
Autor:
Forrest Jessop, Benjamin Schwarz, Dana Scott, Lydia M. Roberts, Eric Bohrnsen, John R. Hoidal, Catharine M. Bosio
Publikováno v:
JCI Insight, Vol 7, Iss 2 (2022)
Cellular and molecular mechanisms driving morbidity following SARS-CoV-2 infection have not been well defined. The receptor for advanced glycation end products (RAGE) is a central mediator of tissue injury and contributes to SARS-CoV-2 disease pathog
Externí odkaz:
https://doaj.org/article/adbd5a2b478a47fc940249de9ad42809
Autor:
Lydia M. Roberts, Benjamin Schwarz, Emily Speranza, Ian Leighton, Tara Wehrly, Sonja Best, Catharine M. Bosio
Publikováno v:
iScience, Vol 24, Iss 9, Pp 103025- (2021)
Summary: Resolution of infection results in development of trained innate immunity which is typically beneficial for defense against unrelated secondary infection. Epigenetic changes including modification of histones via binding of various polar met
Externí odkaz:
https://doaj.org/article/0fbb084a5e6848acb36fa0085865e10e
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 8 (2018)
Francisella tularensis is an intracellular bacterium that causes the disease tularemia. There are several subspecies of F. tularensis whose ability to cause disease varies in humans. The most virulent subspecies, tularensis, is a Tier One Select Agen
Externí odkaz:
https://doaj.org/article/4e10d4eacdbf4243b6ec7bc2d5873c65
Publikováno v:
Applied Biosafety. 26:205-209
Introduction: Fluorescent-activated cell sorting (FACS) is often the most appropriate technique to obtain pure populations of a cell type of interest for downstream analysis. However, aerosol dropl...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6a3be422a3ff226a8df5c451e3ad616c
https://doi.org/10.1089/apb.20.0065
https://doi.org/10.1089/apb.20.0065
Publikováno v:
J Immunol
Immunity to pulmonary infection typically requires elicitation of lung-resident T cells that subsequently confer protection against secondary infection. The presence of tissue-resident T cells in severe acute respiratory syndrome coronavirus 2 (SARS-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e765a50ef884934ba10b421f83515df0
https://doi.org/10.4049/jimmunol.2100608
https://doi.org/10.4049/jimmunol.2100608
Autor:
Xiaohua Peng, Ian Leighton, Arnau Casanovas-Massana, Albert I. Ko, Santos Bermejo, Catharine M. Bosio, Charles S. Dela Cruz, Lokesh Sharma, Benjamin Schwarz, Yale Impact Team, Shelli F. Farhadian, Lydia M. Roberts, Maksym Minasyan
Publikováno v:
Research Square
article-version (status) pre
article-version (number) 1
article-version (status) pre
article-version (number) 1
The COVID-19 pandemic has affected more than 20 million people worldwide, with mortality exceeding 800,000 patients. Risk factors associated with severe disease and mortality include advanced age, hypertension, diabetes, and obesity. Each of these ri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::792c829e3270c6041ec86eb1bc0be4fd
https://doi.org/10.4049/jimmunol.2001025
https://doi.org/10.4049/jimmunol.2001025
Autor:
Benjamin Schwarz, Lydia M. Roberts, Eric Bohrnsen, Forrest Jessop, Tara D. Wehrly, Carl Shaia, Catharine M. Bosio
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 209(7)
Obesity is considered an important comorbidity for a range of noninfectious and infectious disease states including those that originate in the lung, yet the mechanisms that contribute to this susceptibility are not well defined. In this study, we us
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::772cae3963245d5610ae2b7917695dc8
https://pubmed.ncbi.nlm.nih.gov/36002235
https://pubmed.ncbi.nlm.nih.gov/36002235
Autor:
Lydia M. Roberts, Tara D. Wehrly, Ian Leighton, Patrick Hanley, Jamie Lovaglio, Brian J. Smith, Catharine M. Bosio
Publikováno v:
J Immunol
Pulmonary infections elicit a combination of tissue-resident and circulating T cell responses. Understanding the contribution of these anatomically distinct cellular pools in protective immune responses is critical for vaccine development. Francisell
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41a59aec4f7085ce215f2dbe18225887
https://europepmc.org/articles/PMC8881340/
https://europepmc.org/articles/PMC8881340/
Autor:
Emily Speranza, Jyothi N Purushotham, Julia R Port, Benjamin Schwarz, Meaghan Flagg, Brandi N Williamson, Friederike Feldmann, Manmeet Singh, Lizzette Pérez-Pérez, Gail L Sturdevant, Lydia M Roberts, Aaron Carmody, Jonathan E Schulz, Neeltje van Doremalen, Atsushi Okumura, Jamie Lovaglio, Patrick W Hanley, Carl Shaia, Ronald N Germain, Sonja M Best, Vincent J Munster, Catharine M Bosio, Emmie de Wit
Publikováno v:
Life science alliance. 5(4)
Advanced age is a key predictor of severe COVID-19. To gain insight into this relationship, we used the rhesus macaque model of SARS-CoV-2 infection. Eight older and eight younger macaques were inoculated with SARS-CoV-2. Animals were evaluated using
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ccfc40b07da7533d9ffbbc7a517112a
https://pubmed.ncbi.nlm.nih.gov/35039442
https://pubmed.ncbi.nlm.nih.gov/35039442
Autor:
Jyothi N. Purushotham, Julia R Port, Manmeet Singh, Lydia M. Roberts, Jonathan E Schulz, Patrick W. Hanley, Catharine M. Bosio, Atsushi Okumura, Benjamin Schwarz, Gail L. Sturdevant, Brandi N. Williamson, Sonja M. Best, Lizzette Pérez-Pérez, Jamie Lovaglio, Friederike Feldmann, Ronald N. Germain, Emily Speranza, Aaron B. Carmody, Carl Shaia, Emmie de Wit, Vincent J. Munster, Meaghan Flagg, Neeltje van Doremalen
Advanced age is a key predictor of severe COVID-19. To gain insight into this relationship, particularly with respect to immune responses, we utilized the rhesus macaque model of SARS-CoV-2 infection. Two cohorts of eight older (16-23 years) and eigh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::726dae533f9e34fc120335482920f1bb
https://doi.org/10.1101/2021.09.08.459430
https://doi.org/10.1101/2021.09.08.459430