Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Lydia M. Keubler"'
Autor:
Christine Häger, Lydia M Keubler, Steven R Talbot, Svenja Biernot, Nora Weegh, Stephanie Buchheister, Manuela Buettner, Silke Glage, André Bleich
Publikováno v:
PLoS Biology, Vol 16, Iss 10, p e2006159 (2018)
The fine-scale grading of the severity experienced by animals used in research constitutes a key element of the 3Rs (replace, reduce, and refine) principles and a legal requirement in the European Union Directive 2010/63/EU. Particularly, the exact a
Externí odkaz:
https://doaj.org/article/87507949d87143bb8294efc4fdc80418
Autor:
Christine Häger, Lydia M Keubler, Svenja Biernot, Jana Dietrich, Stephanie Buchheister, Manuela Buettner, André Bleich
Publikováno v:
PLoS ONE, Vol 10, Iss 12, p e0143824 (2015)
Severity assessment in laboratory animals is an important issue regarding the implementation of the 3R concept into biomedical research and pivotal in current EU regulations. In mouse models of inflammatory bowel disease severity assessment is usuall
Externí odkaz:
https://doaj.org/article/a9df388000574c51aa50a0261be1552e
Autor:
Heidrun Potschka, Steven R. Talbot, Christine Häger, André Bleich, Lydia M. Keubler, Nils Hoppe, Brigitte Vollmar, Dietmar Zechner
Publikováno v:
Laboratory Animals. 54:50-62
Evidence-based severity assessment in laboratory animals is, apart from the ethical responsibility, imperative to generate reproducible, standardized and valid data. However, the path towards a valid study design determining the degree of pain, distr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3ff06104162e4b4e7d534192155405a8
https://doi.org/10.1177/0023677219877216
https://doi.org/10.1177/0023677219877216
Autor:
Laura Wassermann, M. Hofmann, A. von Knethen, C. Haeger, André Bleich, Tilo Knape, Birgitta Struve, Lydia M. Keubler, Nora Weegh, Paulin Jirkof, Steven R. Talbot, M. Heider
Animal welfare and the refinement of experimental procedures are fundamental aspects of biomedical research. They provide the basis for robust experimental designs and reproducibility of results. In many countries, the determination of welfare is a m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::46a839c7ada850c3e03ea5e89a948eb6
https://doi.org/10.1101/2020.06.23.166801
https://doi.org/10.1101/2020.06.23.166801
Autor:
Inga Bruesch, Lydia M. Keubler, Marijana Basic, Anna Smoczek, Manuela Buettner, Stephanie Buchheister, André Bleich
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-14 (2018)
Scientific Reports
Scientific Reports
The TLR4 co-receptor CD14 was identified as an IBD candidate gene. Here, its influence on the intestinal barrier was addressed utilizing E. coli Nissle (EcN), which induces severe inflammation in germfree TLR4−/− mice. After monoassociation, EcN
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bdb23065b9584a1cfd1f9e2b37993f03
http://link.springer.com/article/10.1038/s41598-017-19062-7
http://link.springer.com/article/10.1038/s41598-017-19062-7
Autor:
André Bleich, Katrin Holst, Oliver Bachmann, Beate Kaune, Lydia M. Keubler, Martin Meier, Manuela Buettner, Silke Glage, Oliver Pabst, Daria Guseva, Evgeni Ponimaskin
Publikováno v:
Inflammatory Bowel Diseases. 20:1516-1529
Background Intestinal inflammation is often associated with an increased level of serotonin (5-HT), an important gastrointestinal signaling molecule involved in gut homeostasis through stimulation of specific receptors. In this study, we investigated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f7b9e5d4d7be0bc45d1687ded282236
https://doi.org/10.1097/mib.0000000000000150
https://doi.org/10.1097/mib.0000000000000150
Autor:
Detlef Neumann, Siegfried Weiss, Anne Jörns, Michael Mähler, Bernd Schröder, Claudia Günther, Marcel Achard, Anna Smoczek, Gerhard Breves, Marijana Basic, Nils H. Zschemisch, André Bleich, Stefan Lienenklaus, Dirk Wedekind, Mathias W. Hornef, Lydia M. Keubler, Manuela Buettner
Publikováno v:
Inflammatory Bowel Diseases. 20:431-443
Background Infection may trigger clinically overt mucosal inflammation in patients with predisposition for inflammatory bowel disease. However, the impact of particular enteropathogenic microorganisms is ill-defined. In this study, the influence of m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dcc4aa94c5402a1ef1f48d4f130815fa
https://doi.org/10.1097/01.mib.0000441346.86827.ed
https://doi.org/10.1097/01.mib.0000441346.86827.ed
Autor:
André Bleich, Lydia M. Keubler, Christoph Pöhlmann, Martin Meier, Svenja Michael, Udo Krause-Buchholz, Hans-J. Hedrich, Anna Smoczek, Florian Gunzer
Publikováno v:
Inflammatory Bowel Diseases. 19:185-193
Background: Although magnetic resonance imaging (MRI) is an increasingly used diagnostic tool in the assessment of inflammatory bowel disease (IBD) in humans, diagnosis and quantitation of intestinal inflammation in animal models of IBD still depends
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12cff02ad62726ec2bdb736cf76fd87a
https://doi.org/10.1002/ibd.23006
https://doi.org/10.1002/ibd.23006
Autor:
Manuela Buettner, Barbara Buchen, Lydia M. Keubler, Christoph Becker, Andreas Noack, André Bleich, Stephanie Buchheister, Gerhard Breves, Marijana Basic
Publikováno v:
The American journal of pathology. 187(5)
Intestinal homeostasis disturbance through intestinal barrier disruption presumably plays a key role in inflammatory bowel disease (IBD) development. Genetic and candidate gene analyses in an Il10-deficient IBD mouse model system identified Cd14 as a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::269f7f179e35364020156e1e86eea716
https://pubmed.ncbi.nlm.nih.gov/28411859
https://pubmed.ncbi.nlm.nih.gov/28411859
Autor:
Steven R. Talbot, Svenja Biernot, Christine Häger, André Bleich, Stephanie Buchheister, Lydia M. Keubler, Manuela Buettner, Nora Weegh, Silke Glage
Publikováno v:
PLoS Biology, Vol 16, Iss 10, p e2006159 (2018)
PLoS Biology
PLoS Biology
The fine-scale grading of the severity experienced by animals used in research constitutes a key element of the 3Rs (replace, reduce, and refine) principles and a legal requirement in the European Union Directive 2010/63/EU. Particularly, the exact a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8beb42257ae63d3768da0286f6355f01
https://doi.org/10.1371/journal.pbio.2006159
https://doi.org/10.1371/journal.pbio.2006159