Insights into the Mechanism of Action and Cellular Targets of Ruthenium Complexes from NMR Spectroscopy

Autor: Federico Giannini, Lydia E. H. Paul, Julien Furrer

Publikováno v: CHIMIA, Vol 66, Iss 10 (2012)

NMR spectroscopy has proved extremely beneficial in the investigation of inorganic drugs from the time that cisplatin was first introduced into the clinic more than 30 years ago. Both 195Pt and 15N NMR were used in early studies and made a major cont

Externí odkaz: https://doaj.org/article/1bcb8dc87c0d41ff9fc4cc2883263737

1H HR-MAS NMR-Based Metabolomics of Cancer Cells in Response to Treatment with the Diruthenium Trithiolato Complex [(p-MeC6H4iPr)2Ru2(SC6H4-p-But)3]+ (DiRu-1)

Autor: Ester Primasová, Lydia E. H. Paul, Martina Vermathen, Julien Furrer, Peter Vermathen, Gaëlle Diserens, Hedvika Primasova

Publikováno v: Metabolites
Primasova, Hedvika; Paul, Lydia; Diserens, Gaëlle; Primasová, Ester; Vermathen, Peter; Vermathen, Martina; Furrer, Julien (2019). 1H HR-MAS NMR-Based Metabolomics of Cancer Cells in Response to Treatment with the Diruthenium Trithiolato Complex [(p-MeC6H4iPr)2Ru2(SC6H4-p-But)3]+ (DiRu-1). Metabolites, 9(7), p. 146. MDPI 10.3390/metabo9070146
Volume 9
Issue 7

The trithiolato bridged diruthenium complex DiRu-1 [(p-MeC6H4iPr)2Ru2(SC6H4-p-But)3]+ is highly cytotoxic against various cancer cell lines, but its exact mode of action remains unknown. The present 1H HR-MAS NMR-based metabolomic study was performed

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c82c83b74edeaaaf04f0096d1ea3e321
http://europepmc.org/articles/PMC6680816

Tuning the in vitro cell cytotoxicity of dinuclear arene ruthenium trithiolato complexes: Influence of the arene ligand

Autor: Georg Süss-Fink, Lydia E. H. Paul, Federico Giannini, Julien Furrer, Thomas Roder, Lennart Geiser, Bruno Therrien

Publikováno v: Journal of Organometallic Chemistry. 783:40-45

A new series of cationic dinuclear arene ruthenium complexes bridged by three thiophenolato ligands, [(η6-arene)2Ru2(μ2-SR)3]+ with arene = indane, R = met: 1 (met = 4-methylphenyl); R = mco: 4 (mco = 4-methylcoumarin-7-yl); arene = biphenyl, R = m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3a735600e2ce68e972c3b9c5b0bd6966
https://doi.org/10.1016/j.jorganchem.2015.02.010

Monothiolato‐Bridged Dinuclear Arene Ruthenium Complexes: The Missing Link in the Reaction of Arene Ruthenium Dichloride Dimers with Thiols

Autor: Federico Giannini, Julien Furrer, Georg Süss-Fink, Lydia E. H. Paul, Bruno Therrien, David Stíbal

Publikováno v: EUROPEAN JOURNAL OF INORGANIC CHEMISTRY

The monothiolato complexes [(η6-p-MeC6H4iPr)2Ru2Cl2(μ-Cl)(μ-SR)] with R = CH2C6H5 (1), p-CH2C6H4NO2 (2), C10H15 (3), m-9-B10C2H11 (4) were synthesized by treating [(η6-p-MeC6H4iPr)2Ru2Cl2(μ-Cl)2] with the corresponding thiols RSH. The reaction o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce2a450f1408109f30c63f3c22a508e8
https://doi.org/10.1002/ejic.201402754

Reactions of a cytotoxic hexanuclear arene ruthenium assembly with biological ligands

Autor: Bruno Therrien, Lydia E. H. Paul, Julien Furrer

Publikováno v: Journal of Organometallic Chemistry. 734:45-52

Reactions between the cytotoxic hexacationic arene ruthenium assembly [( p -cymene) 6 Ru 6 (oxa) 3 (tpt) 2 ] 6+ ([ 1 ] 6+ ) (tpt = 2,4,6-tri(pyridin-4-yl)-1,3,5-triazine and oxa = oxalato) (IC 50 = 0.96 μM against A2780 human ovarian cancer cells) a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2f7f57b74acf6bb28c43e68cb07264dd
https://doi.org/10.1016/j.jorganchem.2012.12.011