The dual developmental origin of spinal cerebrospinal fluid-contacting neurons gives rise to distinct functional subtypes

Autor: Lydia Djenoune, Laura Desban, Johanna Gomez, Jenna R. Sternberg, Andrew Prendergast, Dominique Langui, Feng B. Quan, Hugo Marnas, Thomas O. Auer, Jean-Paul Rio, Filippo Del Bene, Pierre-Luc Bardet, Claire Wyart

Publikováno v: Scientific Reports, Vol 7, Iss 1, Pp 1-14 (2017)

Abstract Chemical and mechanical cues from the cerebrospinal fluid (CSF) can affect the development and function of the central nervous system (CNS). How such cues are detected and relayed to the CNS remains elusive. Cerebrospinal fluid-contacting ne

Externí odkaz: https://doaj.org/article/cee34d7591db4642a247a6dcd272d2df

Comparative distribution and in vitro activities of the urotensin II-related peptides URP1 and URP2 in zebrafish: evidence for their colocalization in spinal cerebrospinal fluid-contacting neurons.

Autor: Feng B Quan, Christophe Dubessy, Sonya Galant, Natalia B Kenigfest, Lydia Djenoune, Jérôme Leprince, Claire Wyart, Isabelle Lihrmann, Hervé Tostivint

Publikováno v: PLoS ONE, Vol 10, Iss 3, p e0119290 (2015)

Urotensin II (UII) is an evolutionarily conserved neuropeptide initially isolated from teleost fish on the basis of its smooth muscle-contracting activity. Subsequent studies have demonstrated the occurrence of several UII-related peptides (URPs), su

Externí odkaz: https://doaj.org/article/a30acbed9da549e6a821201849c04153

CSF-contacting neurons respond to Streptococcus pneumoniae and promote host survival during central nervous system infection

Autor: Andrew E. Prendergast, Kin Ki Jim, Hugo Marnas, Laura Desban, Feng B. Quan, Lydia Djenoune, Valerio Laghi, Agnès Hocquemiller, Elias T. Lunsford, Julian Roussel, Ludovic Keiser, Francois-Xavier Lejeune, Mahalakshmi Dhanasekar, Pierre-Luc Bardet, Jean-Pierre Levraud, Diederik van de Beek, Christina M.J.E. Vandenbroucke-Grauls, Claire Wyart

Publikováno v: Current Biology-CB
Current Biology-CB, 2023, 33 (5), pp.940-956.e10. ⟨10.1016/j.cub.2023.01.039⟩
Current Biology, 33(5), 940-956.e10. Cell Press
Current biology, 33(5), 940-956.e10. Cell Press
Prendergast, A E, Jim, K K, Marnas, H, Desban, L, Quan, F B, Djenoune, L, Laghi, V, Hocquemiller, A, Lunsford, E T, Roussel, J, Keiser, L, Lejeune, F-X, Dhanasekar, M, Bardet, P-L, Levraud, J-P, van de Beek, D, Vandenbroucke-Grauls, C M J E & Wyart, C 2023, ' CSF-contacting neurons respond to Streptococcus pneumoniae and promote host survival during central nervous system infection ', Current Biology, vol. 33, no. 5, pp. 940-956.e10 . https://doi.org/10.1016/j.cub.2023.01.039

International audience; The pathogenic bacterium Streptococcus pneumoniae (S. pneumoniae) can invade the cerebrospinal fluid (CSF) and cause meningitis with devastating consequences. Whether and how sensory cells in the central nervous system (CNS) b

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::96a6d5db27c37c263241139e4461132a
https://hal.science/hal-04032555

Calcium signalling controls podocyte morphogenesis

Autor: Iain A. Drummond, Heiko Schenk, Alejandro Hidalgo-Gonzalez, Irene M. Ghobrial, Jan Hegermann, Lynne Beverly-Staggs, Aude Dorison, Ritu Tomar, Lydia Djenoune, Melissa H. Little

Publikováno v: J Am Soc Nephrol

Background Podocytes are critical to maintaining the glomerular filtration barrier, and mutations in nephrotic syndrome genes are known to affect podocyte calcium signaling. However, the role of calcium signaling during podocyte development remains u

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f0f6d6faeef4ea6a1f23c8001a5b67b
https://pubmed.ncbi.nlm.nih.gov/33911000

CSF-contacting neurons regulate locomotion by relaying mechanical stimuli to spinal circuits

Autor: Johanna Gomez, Caleb Stokes, Andrew Prendergast, J.P. Rio, Maximilliano L. Suster, Jean-Paul Concordet, Sonya Kaiser, Filippo Del Bene, Claire Wyart, Marine Charpentier, Urs Lucas Böhm, Sophie Nunes Figueiredo, Koichi Kawakami, Lydia Djenoune

Publikováno v: Nature Communications, Vol 7, Iss 1, Pp 1-8 (2016)
Nature Communications
Nature Communications, 2016, 7, pp.10866 ⟨10.1038/ncomms10866⟩
Nature Communications, Nature Publishing Group, 2016, 7, pp.10866 ⟨10.1038/ncomms10866⟩

Throughout vertebrates, cerebrospinal fluid-contacting neurons (CSF-cNs) are ciliated cells surrounding the central canal in the ventral spinal cord. Their contribution to modulate locomotion remains undetermined. Recently, we have shown CSF-cNs modu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c51c3ab998e7323b7351e81d3cd91cf
https://doaj.org/article/25791dd165b94a4e9900651c693643a8