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Pkd2l1 is required for mechanoception in cerebrospinal fluid-contacting neurons and maintenance of spine curvature

Autor: Jenna R. Sternberg, Andrew E. Prendergast, Lucie Brosse, Yasmine Cantaut-Belarif, Olivier Thouvenin, Adeline Orts-Del’Immagine, Laura Castillo, Lydia Djenoune, Shusaku Kurisu, Jonathan R. McDearmid, Pierre-Luc Bardet, Claude Boccara, Hitoshi Okamoto, Patrick Delmas, Claire Wyart

Publikováno v: Nature Communications, Vol 9, Iss 1, Pp 1-10 (2018)

Alteration of cerebrospinal fluid (CSF) flow and cilia defects are clinically associated with idiopathic scoliosis. This study shows that transient receptor potential channel Pkd2l1 is required for mechanosensory function of neurons detecting CSF flo

Externí odkaz: https://doaj.org/article/88d9999b54c84d7280f863923497f69e

Pleiotropic role of TRAF7 in skull-base meningiomas and congenital heart disease

Autor: Ketu Mishra-Gorur, Tanyeri Barak, Leon D. Kaulen, Octavian Henegariu, Sheng Chih Jin, Stephanie Marie Aguilera, Ezgi Yalbir, Gizem Goles, Sayoko Nishimura, Danielle Miyagishima, Lydia Djenoune, Selin Altinok, Devendra K. Rai, Stephen Viviano, Andrew Prendergast, Cynthia Zerillo, Kent Ozcan, Burcin Baran, Leman Sencar, Nukte Goc, Yanki Yarman, A. Gulhan Ercan-Sencicek, Kaya Bilguvar, Richard P. Lifton, Jennifer Moliterno, Angeliki Louvi, Shiaulou Yuan, Engin Deniz, Martina Brueckner, Murat Gunel

Publikováno v: Proceedings of the National Academy of Sciences. 120

While somatic variants of TRAF7 (Tumor necrosis factor receptor-associated factor 7) underlie anterior skull-base meningiomas, here we report the inherited mutations of TRAF7 that cause congenital heart defects. We show that TRAF7 mutants operate in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7fac2abf368895a63d99519d0d8f6827
https://doi.org/10.1073/pnas.2214997120

CSF-contacting neurons respond to Streptococcus pneumoniae and promote host survival during central nervous system infection

Autor: Andrew E. Prendergast, Kin Ki Jim, Hugo Marnas, Laura Desban, Feng B. Quan, Lydia Djenoune, Valerio Laghi, Agnès Hocquemiller, Elias T. Lunsford, Julian Roussel, Ludovic Keiser, Francois-Xavier Lejeune, Mahalakshmi Dhanasekar, Pierre-Luc Bardet, Jean-Pierre Levraud, Diederik van de Beek, Christina M.J.E. Vandenbroucke-Grauls, Claire Wyart

Publikováno v: Current Biology-CB
Current Biology-CB, 2023, 33 (5), pp.940-956.e10. ⟨10.1016/j.cub.2023.01.039⟩
Current Biology, 33(5), 940-956.e10. Cell Press
Current biology, 33(5), 940-956.e10. Cell Press
Prendergast, A E, Jim, K K, Marnas, H, Desban, L, Quan, F B, Djenoune, L, Laghi, V, Hocquemiller, A, Lunsford, E T, Roussel, J, Keiser, L, Lejeune, F-X, Dhanasekar, M, Bardet, P-L, Levraud, J-P, van de Beek, D, Vandenbroucke-Grauls, C M J E & Wyart, C 2023, ' CSF-contacting neurons respond to Streptococcus pneumoniae and promote host survival during central nervous system infection ', Current Biology, vol. 33, no. 5, pp. 940-956.e10 . https://doi.org/10.1016/j.cub.2023.01.039

International audience; The pathogenic bacterium Streptococcus pneumoniae (S. pneumoniae) can invade the cerebrospinal fluid (CSF) and cause meningitis with devastating consequences. Whether and how sensory cells in the central nervous system (CNS) b

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::96a6d5db27c37c263241139e4461132a
https://hal.science/hal-04032555

Comparative distribution and in vitro activities of the urotensin II-related peptides URP1 and URP2 in zebrafish: evidence for their colocalization in spinal cerebrospinal fluid-contacting neurons.

Autor: Feng B Quan, Christophe Dubessy, Sonya Galant, Natalia B Kenigfest, Lydia Djenoune, Jérôme Leprince, Claire Wyart, Isabelle Lihrmann, Hervé Tostivint

Publikováno v: PLoS ONE, Vol 10, Iss 3, p e0119290 (2015)

Urotensin II (UII) is an evolutionarily conserved neuropeptide initially isolated from teleost fish on the basis of its smooth muscle-contracting activity. Subsequent studies have demonstrated the occurrence of several UII-related peptides (URPs), su

Externí odkaz: https://doaj.org/article/a30acbed9da549e6a821201849c04153