Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Lydia Delegrange"'
Autor:
Massimo Morbidelli, Guido Ströhlein, Pascal Valax, Michael Schulte, Thomas Müller-Späth, Gianni Baer, Lars Aumann, Henri Kornmann, E. Charbaut, A. Lamproye, Lydia Delegrange, Matthias Jöhnck
Publikováno v:
Biotechnology and Bioengineering. 107:974-984
A two-step chromatography process for monoclonal antibody (mAb) purification from clarified cell culture supernatant (cCCS) was developed using cation exchange Multicolumn Countercurrent Solvent Gradient Purification (MCSGP) as a capture step. After
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c2d287bcfedb0f9fe2fa6e6911222295
https://doi.org/10.1002/bit.22887
https://doi.org/10.1002/bit.22887
Publikováno v:
Journal of chromatography. A. 1298
In order to support a model-based process design in ion-exchange chromatography, an adsorption equilibrium model was adapted to predict the protein retention behavior from the amino acid sequence and from structural information on the resin. It is ba
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::14adb79b603ff8ad43a3fcfde3b681b6
https://pubmed.ncbi.nlm.nih.gov/23759301
https://pubmed.ncbi.nlm.nih.gov/23759301
Autor:
Guido Ströhlein, Massimo Morbidelli, Marco Lattuada, Bertrand Guélat, Pascal Valax, Lydia Delegrange
Publikováno v:
Journal of chromatography. A. 1253
A model was developed for the design of a monoclonal antibody charge variants separation process based on ion-exchange chromatography. In order to account for a broad range of operating conditions in the simulations, an explicit pH and salt concentra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f76e3168626f2e7edb63d5e0486043f7
https://pubmed.ncbi.nlm.nih.gov/22795935
https://pubmed.ncbi.nlm.nih.gov/22795935
Autor:
Massimo Morbidelli, Guido Ströhlein, Pascal Valax, Matthias Jöhnck, Thomas Müller-Späth, Michael Schulte, Henri Kornmann, A. Lamproye, E. Charbaut, Lydia Delegrange, Lars Aumann, Gianni Baer
Publikováno v:
Journal of chromatography. A. 1218(31)
The cation-exchange capture step of a monoclonal antibody (mAb) purification process using single column batch and multicolumn continuous chromatography (MCSGP) was modeled with a lumped kinetic model. Model parameters were experimentally determined
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f7aa4364f1fe1ebbc7123b3d8982dc7
https://pubmed.ncbi.nlm.nih.gov/21696747
https://pubmed.ncbi.nlm.nih.gov/21696747