Zobrazeno 1 - 10
of 47
pro vyhledávání: '"Lydia C, Powell"'
Autor:
Wenya Xue, Manon F. Pritchard, Saira Khan, Lydia C. Powell, Joana Stokniene, Jingxiang Wu, Nicholas Claydon, Paul Reddell, David W. Thomas, Katja E. Hill
Publikováno v:
Journal of Oral Microbiology, Vol 15, Iss 1 (2023)
ABSTRACTBackground Peri-implantitis has become an inexorable clinical challenge in implantology. Topical immunomodulatory epoxy-tiglianes (EBCs), derived from the Queensland blushwood tree, which induce remodeling and resolve dermal infection via ind
Externí odkaz:
https://doaj.org/article/6ffefe779bfc40e689eabbcbca512010
Autor:
Lydia C. Powell, Jennifer Y. M. Adams, Sadik Quoraishi, Charlène Py, Anaϊs Oger, Salvatore A. Gazze, Lewis W. Francis, Christopher von Ruhland, David Owens, Philip D. Rye, Katja E. Hill, Manon F. Pritchard, David W. Thomas
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 13 (2023)
BackgroundThe increasing prevalence of invasive fungal infections in immuno-compromised patients is a considerable cause of morbidity and mortality. With the rapid emergence of antifungal resistance and an inadequate pipeline of new therapies, novel
Externí odkaz:
https://doaj.org/article/15a722be6ea743308e6d0029bab58774
Autor:
Manon F. Pritchard, Lydia C. Powell, Jennifer Y. M. Adams, Georgina Menzies, Saira Khan, Anne Tøndervik, Håvard Sletta, Olav Aarstad, Gudmund Skjåk-Bræk, Stephen McKenna, Niklaas J. Buurma, Damian J. J. Farnell, Philip D. Rye, Katja E. Hill, David W. Thomas
Publikováno v:
Biomolecules, Vol 13, Iss 9, p 1366 (2023)
Low molecular weight alginate oligosaccharides have been shown to exhibit anti-microbial activity against a range of multi-drug resistant bacteria, including Pseudomonas aeruginosa. Previous studies suggested that the disruption of calcium (Ca2+)–D
Externí odkaz:
https://doaj.org/article/1ef3b298ee2142409a846c8cdde536fd
Autor:
Lydia C. Powell, Muthanna Abdulkarim, Joana Stokniene, Qiu E. Yang, Timothy R. Walsh, Katja E. Hill, Mark Gumbleton, David W. Thomas
Publikováno v:
npj Biofilms and Microbiomes, Vol 7, Iss 1, Pp 1-11 (2021)
Abstract Novel therapeutics designed to target the polymeric matrix of biofilms requires innovative techniques to accurately assess their efficacy. Here, multiple particle tracking (MPT) was developed to characterize the physical and mechanical prope
Externí odkaz:
https://doaj.org/article/3d2fc454891849a6909b5596529837e7
Autor:
Lewis W. Francis, Seydou N. Yao, Lydia C. Powell, Sean Griffiths, Alexander Berquand, Thomas Piasecki, William Howe, Andrea S. Gazze, Mary C. Farach-Carson, Pamela Constantinou, Daniel Carson, Lavinia Margarit, Deya Gonzalez, R. Steven Conlan
Publikováno v:
Journal of Nanobiotechnology, Vol 19, Iss 1, Pp 1-13 (2021)
Abstract Background Sialyl-Lewis X/L-selectin high affinity binding interactions between transmembrane O-glycosylated mucins proteins and the embryo have been implicated in implantation processes within the human reproductive system. However, the adh
Externí odkaz:
https://doaj.org/article/5b74fbf0ce1748cc811e295453179805
Autor:
Juliette L. Oakley, Rebecca Weiser, Lydia C. Powell, Julian Forton, Eshwar Mahenthiralingam, Philip D. Rye, Katja E. Hill, David W. Thomas, Manon F. Pritchard
Publikováno v:
mSphere, Vol 6, Iss 1 (2021)
The emergence of multidrug-resistant (MDR) pathogens within biofilms in the cystic fibrosis lung results in increased morbidity. An inhalation therapy derived from alginate, OligoG CF-5/20, is currently in clinical trials for cystic fibrosis patients
Externí odkaz:
https://doaj.org/article/69b2a04dbbcf488f9126a89eebd683a2
Autor:
Elaine L. Ferguson, Sameza Naseer, Lydia C. Powell, Joseph Hardwicke, Fraser I. Young, Bangfu Zhu, Qian Liu, Bing Song, David W. Thomas
Publikováno v:
Stem Cell Research, Vol 33, Iss , Pp 69-78 (2018)
An essential aspect of stem cell in vitro culture and in vivo therapy is achieving sustained levels of growth factors to support stem cell survival and expansion, while maintaining their multipotency and differentiation potential. This study investig
Externí odkaz:
https://doaj.org/article/d0ba3d37481549e3969e6314d7acd88f
Autor:
Zara Ahmed, Lydia C. Powell, Navid Matin, Andrew Mearns-Spragg, Catherine A. Thornton, Ilyas M. Khan, Lewis W. Francis
Publikováno v:
Marine Drugs, Vol 19, Iss 8, p 405 (2021)
Osteoarthritis (OA) is a multifactorial disease leading to degeneration of articular cartilage, causing morbidity in approximately 8.5 million of the UK population. As the dense extracellular matrix of articular cartilage is primarily composed of col
Externí odkaz:
https://doaj.org/article/b1f4bf115947424d889841d8b9a23a22
Publikováno v:
Frontiers in Microbiology, Vol 10 (2019)
Pseudomonas aeruginosa causes problematic chronic lung infections in those suffering from cystic fibrosis. This is due to its antimicrobial resistance mechanisms and its ability to form robust biofilm communities with increased antimicrobial toleranc
Externí odkaz:
https://doaj.org/article/9564bec40d104bbfbaaa77cc8e03c58b
Autor:
Joana Stokniene, Lydia C. Powell, Olav A. Aarstad, Finn L. Aachmann, Philip D. Rye, Katja E. Hill, David W. Thomas, Elaine L. Ferguson
Publikováno v:
Pharmaceutics, Vol 12, Iss 11, p 1080 (2020)
The recent emergence of resistance to colistin, an antibiotic of last resort with dose-limiting toxicity, has highlighted the need for alternative approaches to combat infection. This study aimed to generate and characterise alginate oligosaccharide
Externí odkaz:
https://doaj.org/article/df731059db5642c38c20a20acdabae25