Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Lydia Barrigan"'
Autor:
Jun Li, Maureen J. Gorman, Keshar Prasain, Duy H. Hua, Lydia Barrigan, Michael R. Kanost, Lateef U. Syed, Thi D.T. Nguyen, Kun Yan Zhu, Zeyu Peng
Publikováno v:
Bioorganic & Medicinal Chemistry. 20:1679-1689
Laccases are copper-containing oxidases that are involved in sclerotization of the cuticle of mosquitoes and other insects. Oxidation of exogenous compounds by insect laccases may have the potential to produce reactive species toxic to insects. We in
Autor:
Sandeep Rana, Aibin Shi, Hyun Seok Hong, Yi Zhang, Lydia Barrigan, Lee-Way Jin, Feimeng Zhou, Duy H. Hua
Publikováno v:
Journal of Neurochemistry. 108:1097-1108
Small beta-amyloid (Abeta) 1-42 aggregates are toxic to neurons and may be the primary toxic species in Alzheimer's disease (AD). Methods to reduce the level of Abeta, prevent Abeta aggregation, and eliminate existing Abeta aggregates have been propo
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 19:670-674
The SbetaC gene is conditionally expressed a 99-residue carboxy terminal fragment, C99, of amyloid precursor protein in MC65 cells and causes cell death. Consequently, MC65 cell line was used to identify inhibitors of toxicity related to intracellula
Autor:
Lydia Barrigan, Shraddha Tuladhar, Jason Brunton, Matthew Woolard, Ching-ju Chen, Divey Saini, Richard Frothingham, Gregory Sempowski, Thomas Kawula, Jeffrey Frelinger
Publikováno v:
The Journal of Immunology. 190:186.10-186.10
Bacterial infections typically initiate both innate and adaptive immune responses. Bacterial attenuation is thought of as altered bacterial growth in the presence of constant immune pressure. In vivo screens have identified F. tularensis genes necess
Publikováno v:
The Journal of Immunology. 188:117.7-117.7
Francisella tularensis is highly virulent and infectious bacterial pathogen and a category A select agent. Many aspects of immunity to the infection are not well understood. This study is part of ongoing work to understand the immune response followi
Autor:
Lydia Barrigan, Shaun Steele, Shraddha Tuladhar, Matthew Woolard, Thomas Kawula, Jeffrey Frelinger
Publikováno v:
The Journal of Immunology. 186:99.2-99.2
The bacterium Francisella tularensis is the causative agent of tularemia. F. tularensis induces a host response that is dependent on the route of infection. Intranasal (i.n.) inoculations are more virulent and require fewer bacteria to produce a leth