Blocking dPerk in the intestine suppresses neurodegeneration in a Drosophila model of Parkinson’s disease

Autor: Rebeka Popovic, Amrita Mukherjee, Nuno Santos Leal, Lydia Morris, Yizhou Yu, Samantha H. Y. Loh, L. Miguel Martins

Publikováno v: Cell Death and Disease, Vol 14, Iss 3, Pp 1-9 (2023)

Abstract Parkinson’s disease (PD) is characterised by selective death of dopaminergic (DA) neurons in the midbrain and motor function impairment. Gastrointestinal issues often precede motor deficits in PD, indicating that the gut-brain axis is invo

Externí odkaz: https://doaj.org/article/6ebc6adba57e4b589a5e06e303d898c6

Evaluating a tool to improve engagement and recruitment of under-served groups in trials

Autor: Lydia Morris, Jo Dumville, Shaun Treweek, Nasima Miah, Ffion Curtis, Peter Bower

Publikováno v: Trials, Vol 23, Iss 1, Pp 1-13 (2022)

Abstract Background Despite substantial awareness that certain groups (e.g. ethnic minorities) are under-represented and under-served in trials, limited progress has been made in addressing this. As well as a public service and ethical duty to recrui

Externí odkaz: https://doaj.org/article/1d441d459e8843a4ab394d2b52b94e11

A brief transdiagnostic group (the take control course) compared to individual low-intensity CBT for depression and anxiety: a randomized non-inferiority trial

Autor: Lydia Morris, Karina Lovell, Phil McEvoy, Richard Emsley, Lesley-Anne Carter, Dawn Edge, Rachel Bates, Tanya Wallwork, Warren Mansell

Publikováno v: Morris, L, Lovell, K, McEvoy, P, Emsley, R, Carter, L-A, Edge, D, Bates, R, Wallwork, T & Mansell, W 2023, ' A brief transdiagnostic group (the take control course) compared to individual low-intensity CBT for depression and anxiety : a randomized non-inferiority trial ', Cognitive Behaviour Therapy, pp. 1-22 . https://doi.org/10.1080/16506073.2022.2143418

Few studies have examined brief transdiagnostic groups. The Take Control Course (TCC) was developed for patients with mild to moderate common mental health problems. We examined whether TCC is non-inferior to individual low-intensity cognitive behavi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd0b6ad6706bd18dab16f255d89e1278
https://doi.org/10.1080/16506073.2022.2143418

The human cognition-enhancing CORD7 mutation increases active zone number and synaptic release

Autor: Mila M Paul, Sven Dannhäuser, Lydia Morris, Achmed Mrestani, Martha Hübsch, Jennifer Gehring, Georgios N Hatzopoulos, Martin Pauli, Genevieve M Auger, Grit Bornschein, Nicole Scholz, Dmitrij Ljaschenko, Martin Müller, Markus Sauer, Hartmut Schmidt, Robert J Kittel, Aaron DiAntonio, Ioannis Vakonakis, Manfred Heckmann, Tobias Langenhan

Publikováno v: Brain. 145:3787-3802

Humans carrying the CORD7 (cone-rod dystrophy 7) mutation possess increased verbal IQ and working memory. This autosomal dominant syndrome is caused by the single-amino acid R844H exchange (human numbering) located in the 310 helix of the C2A domain

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e229fbac4d1fe4e89715e64bf18abcc
https://doi.org/10.1093/brain/awac011

Communication in dementia: The development of a new understanding and training intervention that is informed by perceptual control theory

Autor: Phil McEvoy, Lydia Morris

Publikováno v: The Interdisciplinary Handbook of Perceptual Control Theory, Volume II ISBN: 9780323911658

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c85bf83a18bfc274abb17280c12e7610
https://doi.org/10.1016/b978-0-323-91165-8.00017-2