Zobrazeno 1 - 10
of 71
pro vyhledávání: '"Lydia, Hopp"'
Autor:
Maria Keller, Anat Yaskolka Meir, Stephan H. Bernhart, Yftach Gepner, Ilan Shelef, Dan Schwarzfuchs, Gal Tsaban, Hila Zelicha, Lydia Hopp, Luise Müller, Kerstin Rohde, Yvonne Böttcher, Peter F. Stadler, Michael Stumvoll, Matthias Blüher, Peter Kovacs, Iris Shai
Publikováno v:
Genome Medicine, Vol 12, Iss 1, Pp 1-18 (2020)
Abstract Background One of the major challenges in obesity treatment is to explain the high variability in the individual’s response to specific dietary and physical activity interventions. With this study, we tested the hypothesis that specific DN
Externí odkaz:
https://doaj.org/article/33ede6e903294fe194e287bc21e66322
Autor:
Henry Loeffler-Wirth, Markus Kreuz, Lydia Hopp, Arsen Arakelyan, Andrea Haake, Sergio B. Cogliatti, Alfred C. Feller, Martin-Leo Hansmann, Dido Lenze, Peter Möller, Hans Konrad Müller-Hermelink, Erik Fortenbacher, Edith Willscher, German Ott, Andreas Rosenwald, Christiane Pott, Carsten Schwaenen, Heiko Trautmann, Swen Wessendorf, Harald Stein, Monika Szczepanowski, Lorenz Trümper, Michael Hummel, Wolfram Klapper, Reiner Siebert, Markus Loeffler, Hans Binder, for the German Cancer Aid consortium Molecular Mechanisms for Malignant Lymphoma
Publikováno v:
Genome Medicine, Vol 11, Iss 1, Pp 1-20 (2019)
Abstract Background Germinal center-derived B cell lymphomas are tumors of the lymphoid tissues representing one of the most heterogeneous malignancies. Here we characterize the variety of transcriptomic phenotypes of this disease based on 873 biopsy
Externí odkaz:
https://doaj.org/article/eb092f16cead48828dfcb25f4bc14f5e
Autor:
Maria Schmidt, Lydia Hopp, Arsen Arakelyan, Holger Kirsten, Christoph Engel, Kerstin Wirkner, Knut Krohn, Ralph Burkhardt, Joachim Thiery, Markus Loeffler, Henry Loeffler-Wirth, Hans Binder
Publikováno v:
Frontiers in Big Data, Vol 3 (2020)
Background: The blood transcriptome is expected to provide a detailed picture of an organism's physiological state with potential outcomes for applications in medical diagnostics and molecular and epidemiological research. We here present the analysi
Externí odkaz:
https://doaj.org/article/f74d5d749ea04c20b9586801a0143196
Autor:
Henry Loeffler-Wirth, Lydia Hopp, Maria Schmidt, Roksana Zakharyan, Arsen Arakelyan, Hans Binder
Publikováno v:
Cells, Vol 11, Iss 3, p 362 (2022)
Mutually linked expression and methylation dynamics in the brain govern genome regulation over the whole lifetime with an impact on cognition, psychological disorders, and cancer. We performed a joint study of gene expression and DNA methylation of b
Externí odkaz:
https://doaj.org/article/1721851f9cb349d6853688aba0eece3f
Publikováno v:
Epigenetics, Vol 12, Iss 10, Pp 886-896 (2017)
In acute myeloid leukemia (AML) DNA hypermethylation of gene promoters is frequently observed and often correlates with a block of differentiation. Treatment of AML patients with DNA methyltransferase inhibitors results in global hypomethylation of g
Externí odkaz:
https://doaj.org/article/0c46c74deb3840268875593564b28cbf
Autor:
Maria Keller, Lydia Hopp, Xuanshi Liu, Tobias Wohland, Kerstin Rohde, Raffaella Cancello, Matthias Klös, Karl Bacos, Matthias Kern, Fabian Eichelmann, Arne Dietrich, Michael R. Schön, Daniel Gärtner, Tobias Lohmann, Miriam Dreßler, Michael Stumvoll, Peter Kovacs, Anna-Maria DiBlasio, Charlotte Ling, Hans Binder, Matthias Blüher, Yvonne Böttcher
Publikováno v:
Molecular Metabolism, Vol 6, Iss 1, Pp 86-100 (2017)
Objective/methods: DNA methylation plays an important role in obesity and related metabolic complications. We examined genome-wide DNA promoter methylation along with mRNA profiles in paired samples of human subcutaneous adipose tissue (SAT) and omen
Externí odkaz:
https://doaj.org/article/c1877cfcd2a94501ad23387fe0134a06
Autor:
Lilit Nersisyan, Lydia Hopp, Henry Loeffler-Wirth, Jörg Galle, Markus Loeffler, Arsen Arakelyan, Hans Binder
Publikováno v:
Frontiers in Oncology, Vol 9 (2019)
Background: Activation of telomere maintenance mechanisms (TMMs) is a hallmark of most cancers, and is required to prevent genome instability and to establish cellular immortality through reconstitution of capping of chromosome ends. TMM depends on t
Externí odkaz:
https://doaj.org/article/319bc174e6094d6bb75a195fe383539d
Publikováno v:
Frontiers in Immunology, Vol 9 (2018)
We analyzed the blood transcriptome of sepsis framed within community-acquired pneumonia (CAP) and characterized its molecular and cellular heterogeneity in terms of functional modules of co-regulated genes with impact for the underlying pathophysiol
Externí odkaz:
https://doaj.org/article/8401f65a44c04d21904b641f4fa7644e
Autor:
Hans Binder, Maria Schmidt, Lydia Hopp, Suren Davitavyan, Arsen Arakelyan, Henry Loeffler-Wirth
Publikováno v:
Cancers; Volume 14; Issue 11; Pages: 2797
Multi-omics high-throughput technologies produce data sets which are not restricted to only one but consist of multiple omics modalities, often as patient-matched tumour specimens. The integrative analysis of these omics modalities is essential to ob
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b49b13f01e35be2c67088e7da4ea0e5c
https://pubmed.ncbi.nlm.nih.gov/35681780
https://pubmed.ncbi.nlm.nih.gov/35681780
Publikováno v:
Biology, Vol 2, Iss 4, Pp 1411-1437 (2013)
We present an analytic framework based on Self-Organizing Map (SOM) machine learning to study large scale patient data sets. The potency of the approach is demonstrated in a case study using gene expression data of more than 200 mature aggressive B-c
Externí odkaz:
https://doaj.org/article/01b24848c444485f91ddfcd75d8f4fbf