The mitochondrial DNA constitution shaping T cell immunity in patients with rectal cancer at high risk of metastatic progression

Autor: Lüders T, Anne Hansen Ree, Juul H, Lyckander Lg, Johansen C, Bousquet P, Inderberg Em, Esbensen Y, Kersten C, Anniken Jørlo Fuglestad, Meltzer S, Bjørnetrø T, Kathrine Røe Redalen

A significant percentage of colorectal cancer patients proceeds to metastatic disease. We hypothesised that mitochondrial DNA (mtDNA) polymorphisms, generated by the high mtDNA mutation rate of energy-demanding clonal immune cell expansions and asses

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::34dd5ad043730276af8247edc4450293
https://doi.org/10.22541/au.162361415.51409527/v1

The mitochondrial DNA constitution shaping T-cell immunity in patients with rectal cancer at high risk of metastatic progression.

Autor: Bousquet PA; Department of Oncology, Akershus University Hospital, Lorenskog, Norway., Meltzer S; Department of Oncology, Akershus University Hospital, Lorenskog, Norway., Fuglestad AJ; Department of Oncology, Akershus University Hospital, Lorenskog, Norway.; Institute of Clinical Medicine, University of Oslo, Oslo, Norway.; Centre for Cancer Treatment, Sørlandet Hospital, Kristiansand, Norway., Lüders T; Institute of Clinical Medicine, University of Oslo, Oslo, Norway.; Department of Clinical Molecular Biology, Akershus University Hospital, Lorenskog, Norway., Esbensen Y; Institute of Clinical Medicine, University of Oslo, Oslo, Norway.; Department of Clinical Molecular Biology, Akershus University Hospital, Lorenskog, Norway., Juul HV; Department of Cellular Therapy, Oslo University Hospital, Oslo, Norway., Johansen C; Department of Oncology, Akershus University Hospital, Lorenskog, Norway., Lyckander LG; Department of Pathology, Akershus University Hospital, Lorenskog, Norway., Bjørnetrø T; Department of Oncology, Akershus University Hospital, Lorenskog, Norway., Inderberg EM; Department of Cellular Therapy, Oslo University Hospital, Oslo, Norway., Kersten C; Department of Oncology, Akershus University Hospital, Lorenskog, Norway.; Centre for Cancer Treatment, Sørlandet Hospital, Kristiansand, Norway., Redalen KR; Department of Oncology, Akershus University Hospital, Lorenskog, Norway.; Department of Physics, Norwegian University of Science and Technology, Trondheim, Norway., Ree AH; Department of Oncology, Akershus University Hospital, Lorenskog, Norway. a.h.ree@medisin.uio.no.; Institute of Clinical Medicine, University of Oslo, Oslo, Norway. a.h.ree@medisin.uio.no.

Publikováno v: Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico [Clin Transl Oncol] 2022 Jun; Vol. 24 (6), pp. 1157-1167. Date of Electronic Publication: 2021 Dec 27.

Stratification of Stage III colon cancer may identify a patient group not requiring adjuvant chemotherapy.

Autor: Malik YG; Department of Digestive Surgery, Akershus University Hospital, Sykehusveien 25, 1478, Lørenskog, Norway. Yasir.Gulzar.Malik@ahus.no.; Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, Norway. Yasir.Gulzar.Malik@ahus.no., Lyckander LG; Department of Pathology, Akershus University Hospital, Lørenskog, Norway., Lindstrøm JC; Health Services Research Unit, Akershus University Hospital, Lørenskog, Norway., Vinge-Holmquist O; Department of Digestive Surgery, Akershus University Hospital, Sykehusveien 25, 1478, Lørenskog, Norway., Sheikh AE; Department of Digestive Surgery, Akershus University Hospital, Sykehusveien 25, 1478, Lørenskog, Norway., Schultz JK; Department of Digestive Surgery, Akershus University Hospital, Sykehusveien 25, 1478, Lørenskog, Norway., Ignjatovic D; Department of Digestive Surgery, Akershus University Hospital, Sykehusveien 25, 1478, Lørenskog, Norway.; Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, Norway.

Publikováno v: Journal of cancer research and clinical oncology [J Cancer Res Clin Oncol] 2021 Jan; Vol. 147 (1), pp. 61-71. Date of Electronic Publication: 2020 Sep 13.

Sex-related differences in primary metastatic site in rectal cancer; associated with hemodynamic factors?

Autor: Meltzer S; Department of Oncology, Akershus University Hospital, Lørenskog, Norway., Bakke KM; Department of Oncology, Akershus University Hospital, Lørenskog, Norway.; Department of Physics, University of Oslo, Oslo, Norway., Rød KL; Department of Physics, Norwegian University of Science and Technology, Trondheim, Norway.; Department of Medical Physics, Oslo University Hospital Norwegian Radium Hospital, Oslo, Norway., Negård A; Department of Radiology, Akershus University Hospital, Lørenskog, Norway.; Institute of Clinical Medicine, University of Oslo, Oslo, Norway., Flatmark K; Institute of Clinical Medicine, University of Oslo, Oslo, Norway.; Department of Tumor Biology, Oslo University Hospital - Norwegian Radium Hospital, Oslo, Norway.; Department of Gastroenterological Surgery, Oslo University Hospital - Norwegian Radium Hospital, Oslo, Norway., Solbakken AM; Department of Gastroenterological Surgery, Oslo University Hospital - Norwegian Radium Hospital, Oslo, Norway., Kristensen AT; Department of Tumor Biology, Oslo University Hospital - Norwegian Radium Hospital, Oslo, Norway., Fuglestad AJ; Center for Cancer Treatment, Sørlandet Hospital, Kristiansand, Norway., Kersten C; Center for Cancer Treatment, Sørlandet Hospital, Kristiansand, Norway., Dueland S; Department of Oncology, Oslo University Hospital - Norwegian Radium Hospital, Oslo, Norway., Seierstad T; Department of Research and Development, Division for Radiology and Nuclear Medicine, Oslo University Hospital, Oslo, Norway., Hole KH; Institute of Clinical Medicine, University of Oslo, Oslo, Norway.; Department of Radiology, Oslo University Hospital, Oslo, Norway., Lyckander LG; Department of Pathology, Akershus University Hospital, Lørenskog, Norway., Larsen FO; Department of Oncology, Herlev and Gentofte Hospital, Herlev, Denmark., Schou JV; Department of Oncology, Herlev and Gentofte Hospital, Herlev, Denmark., Patrick Brown D; Department of Oncology, Akershus University Hospital, Lørenskog, Norway.; Department of Tumor Biology, Oslo University Hospital - Norwegian Radium Hospital, Oslo, Norway., Abrahamsson H; Department of Oncology, Akershus University Hospital, Lørenskog, Norway.; Institute of Clinical Medicine, University of Oslo, Oslo, Norway., Redalen KR; Department of Oncology, Akershus University Hospital, Lørenskog, Norway.; Department of Physics, Norwegian University of Science and Technology, Trondheim, Norway., Ree AH; Department of Oncology, Akershus University Hospital, Lørenskog, Norway.; Institute of Clinical Medicine, University of Oslo, Oslo, Norway.

Publikováno v: Clinical and translational radiation oncology [Clin Transl Radiat Oncol] 2019 Dec 02; Vol. 21, pp. 5-10. Date of Electronic Publication: 2019 Dec 02 (Print Publication: 2020).

Circulating Exosomal miR-141-3p and miR-375 in Metastatic Progression of Rectal Cancer.

Autor: Meltzer S; Department of Oncology, Akershus University Hospital, 1478 Lørenskog, Norway. Electronic address: sebastian.meltzer@medisin.uio.no., Bjørnetrø T; Department of Oncology, Akershus University Hospital, 1478 Lørenskog, Norway; Institute of Clinical Medicine, University of Oslo, 0318 Oslo, Norway., Lyckander LG; Department of Pathology, Akershus University Hospital, 1478 Lørenskog., Flatmark K; Department of Gastroenterological Surgery, Oslo University Hospital, 0424 Oslo, Norway; Department of Tumor Biology, Oslo University Hospital, 0424 Oslo, Norway; Institute of Clinical Medicine, University of Oslo, 0318 Oslo, Norway., Dueland S; Department of Oncology, Oslo University Hospital, 0424 Oslo, Norway., Samiappan R; Department of Bioscience and Nutrition, Karolinska Institutet, SE-141 83 Huddinge, Sweden., Johansen C; Department of Oncology, Akershus University Hospital, 1478 Lørenskog, Norway., Kalanxhi E; Department of Oncology, Akershus University Hospital, 1478 Lørenskog, Norway., Ree AH; Department of Oncology, Akershus University Hospital, 1478 Lørenskog, Norway; Institute of Clinical Medicine, University of Oslo, 0318 Oslo, Norway., Redalen KR; Department of Oncology, Akershus University Hospital, 1478 Lørenskog, Norway; Department of Physics, Norwegian University of Science and Technology, 7491 Trondheim, Norway.

Publikováno v: Translational oncology [Transl Oncol] 2019 Aug; Vol. 12 (8), pp. 1038-1044. Date of Electronic Publication: 2019 May 27.