Zobrazeno 1 - 10
of 87
pro vyhledávání: '"Lyanne C. Schlichter"'
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 12 (2018)
Addressing potential sex differences in pre-clinical studies is crucial for developing therapeutic interventions. Although sex differences have been reported in epidemiological studies and from clinical experience, most pre-clinical studies of neuroi
Externí odkaz:
https://doaj.org/article/f79b343da1114ed3803fe138ea2015e7
Autor:
Starlee Lively, Lyanne C. Schlichter
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 12 (2018)
Microglia respond to CNS injuries and diseases with complex reactions, often called “activation.” A pro-inflammatory phenotype (also called classical or M1 activation) lies at one extreme of the reactivity spectrum. There were several motivations
Externí odkaz:
https://doaj.org/article/bcfce1d6c83a49d18011611db11e82bd
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 12 (2018)
The cytokine, transforming growth factor β1 (TGFβ1), is up-regulated after central nervous system (CNS) injuries or diseases involving microglial activation, and it has been proposed as a therapeutic agent for treating neuroinflammation. Microglia
Externí odkaz:
https://doaj.org/article/450b494dc5214affb94fc353b59c7c4a
Autor:
Sachiko Sato, Jasna Kriz, Starlee Lively, Reza Rahimian, Lyanne C. Schlichter, Mélanie Lalancette-Hébert, Essam Abdelhamid
Publikováno v:
Molecular neurobiology. 56(9)
Galectin-3 (Gal-3), a β-galactoside-binding lectin, has recently emerged as a molecule with immunoregulatory functions. We investigated the effects of Gal-3 on microglia morphology, migration, and secretory profile under physiological conditions and
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 12 (2018)
Frontiers in Cellular Neuroscience
Frontiers in Cellular Neuroscience
Addressing potential sex differences in pre-clinical studies is crucial for developing therapeutic interventions. Although sex differences have been reported in epidemiological studies and from clinical experience, most pre-clinical studies of neuroi
Publikováno v:
Journal of Neuropathology and Experimental Neurology
Within hours after stroke, potentially cytotoxic pro-inflammatory mediators are elevated within the brain; thus, one potential therapeutic strategy is to reduce them and skew the brain toward an anti-inflammatory state. Because interleukin-4 (IL-4) t
Publikováno v:
Translational Stroke Research
Damage to myelinated axons contributes to neurological deficits after acute CNS injury, including ischemic and hemorrhagic stroke. Potential treatments to promote re-myelination will require fully differentiated oligodendrocytes, but almost nothing i
Autor:
Lyanne C. Schlichter, Starlee Lively
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 12 (2018)
Frontiers in Cellular Neuroscience
Frontiers in Cellular Neuroscience
Microglia respond to CNS injuries and diseases with complex reactions, often called “activation.” A pro-inflammatory phenotype (also called classical or M1 activation) lies at one extreme of the reactivity spectrum. There were several motivations
Publikováno v:
Journal of Neuroinflammation
Background Acute CNS damage is commonly studied using rat and mouse models, but increasingly, molecular analysis is finding species differences that might affect the ability to translate findings to humans. Microglia can undergo complex molecular and
Autor:
Raymond Wong, Lyanne C. Schlichter
Publikováno v:
The Journal of Neuroscience. 34:13371-13383
The Ca2+-dependent K+channel, KCa3.1 (KCNN4/IK/SK4), is widely expressed and contributes to cell functions that include volume regulation, migration, membrane potential, and excitability. KCa3.1 is now considered a therapeutic target for several dise