Zobrazeno 1 - 10
of 87
pro vyhledávání: '"Lyanne C Schlichter"'
Publikováno v:
PLoS ONE, Vol 9, Iss 2, p e90024 (2014)
Members of the EAG K(+) channel superfamily (EAG/Kv10.x, ERG/Kv11.x, ELK/Kv12.x subfamilies) are expressed in many cells and tissues. In particular, two prototypes, EAG1/Kv10.1/KCNH1 and ERG1/Kv11.1/KCNH2 contribute to both normal and pathological fu
Externí odkaz:
https://doaj.org/article/7093a1f01e3e4f7c907a579ecce07563
Publikováno v:
PLoS ONE, Vol 9, Iss 8, p e106087 (2014)
Microglia rapidly respond to CNS injury and disease and can assume a spectrum of activation states. While changes in gene expression and production of inflammatory mediators have been extensively described after classical (LPS-induced) and alternativ
Externí odkaz:
https://doaj.org/article/4ccfeed7c396415b847fec270229c9e1
Autor:
Roger Ferreira, Lyanne C Schlichter
Publikováno v:
PLoS ONE, Vol 8, Iss 4, p e62345 (2013)
Microglial activation involves Ca(2+) signaling, and numerous receptors can evoke elevation of intracellular Ca(2+). ATP released from damaged brain cells can activate ionotropic and metabotropic purinergic receptors, and act as a chemoattractant for
Externí odkaz:
https://doaj.org/article/97a317c8f5ef4010a4e01796ace85e3c
Autor:
Sachiko Sato, Jasna Kriz, Starlee Lively, Reza Rahimian, Lyanne C. Schlichter, Mélanie Lalancette-Hébert, Essam Abdelhamid
Publikováno v:
Molecular neurobiology. 56(9)
Galectin-3 (Gal-3), a β-galactoside-binding lectin, has recently emerged as a molecule with immunoregulatory functions. We investigated the effects of Gal-3 on microglia morphology, migration, and secretory profile under physiological conditions and
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 12 (2018)
Frontiers in Cellular Neuroscience
Frontiers in Cellular Neuroscience
Addressing potential sex differences in pre-clinical studies is crucial for developing therapeutic interventions. Although sex differences have been reported in epidemiological studies and from clinical experience, most pre-clinical studies of neuroi
Publikováno v:
Journal of Neuropathology and Experimental Neurology
Within hours after stroke, potentially cytotoxic pro-inflammatory mediators are elevated within the brain; thus, one potential therapeutic strategy is to reduce them and skew the brain toward an anti-inflammatory state. Because interleukin-4 (IL-4) t
Publikováno v:
Translational Stroke Research
Damage to myelinated axons contributes to neurological deficits after acute CNS injury, including ischemic and hemorrhagic stroke. Potential treatments to promote re-myelination will require fully differentiated oligodendrocytes, but almost nothing i
Autor:
Lyanne C. Schlichter, Starlee Lively
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 12 (2018)
Frontiers in Cellular Neuroscience
Frontiers in Cellular Neuroscience
Microglia respond to CNS injuries and diseases with complex reactions, often called “activation.” A pro-inflammatory phenotype (also called classical or M1 activation) lies at one extreme of the reactivity spectrum. There were several motivations
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 12 (2018)
Frontiers in Cellular Neuroscience
Frontiers in Cellular Neuroscience
The cytokine, transforming growth factor β1 (TGFβ1), is up-regulated after central nervous system (CNS) injuries or diseases involving microglial activation, and it has been proposed as a therapeutic agent for treating neuroinflammation. Microglia
Publikováno v:
Journal of Neuroinflammation
Background Acute CNS damage is commonly studied using rat and mouse models, but increasingly, molecular analysis is finding species differences that might affect the ability to translate findings to humans. Microglia can undergo complex molecular and