Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Lyann M. B. Ursos"'
Publikováno v:
The Journal of Physical Chemistry A. 107:5821-5825
By examining natural-abundance 13C and 15N solid-state nuclear magnetic resonance (NMR) spectra of acid-precipitated chloroquine−ferriprotoporphyrin IX (CQ−FPIX) aggregates, the first direct evidence is provided for CQ−FPIX complexes in the sol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f8d908c7c447dbd6f21e5b2078e1f084
https://doi.org/10.1021/jp0342982
https://doi.org/10.1021/jp0342982
Autor:
Paul D. Roepe, Lyann M. B. Ursos
Publikováno v:
Medicinal Research Reviews. 22:465-491
Malarial parasites remain a health problem of staggering proportions. Worldwide, they infect about 500 million, incapacitate tens of millions, and kill approximately 2.5 million (mostly children) annually. Four species infect humans, but most deaths
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d77d5cc2f54e833c699d1a8e1cacf62e
https://doi.org/10.1002/med.10016
https://doi.org/10.1002/med.10016
Autor:
Amar Bir Singh Sidhu, Bronwen Naudé, Kirk W. Deitsch, Angela K. Talley, Takashi Nomura, Roland A. Cooper, Sergey M. Dzekunov, Lyann M. B. Ursos, David A. Fidock, John C. Wootton, Paul D. Roepe, Thomas E. Wellems, Xin-zhuan Su, Michael T. Ferdig
Publikováno v:
Molecular Cell. 6:861-871
The determinant of verapamil-reversible chloroquine resistance (CQR) in a Plasmodium falciparum genetic cross maps to a 36 kb segment of chromosome 7. This segment harbors a 13-exon gene, pfcrt, having point mutations that associate completely with C
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0068647106f873f7c31a86e5da9af8ed
https://doi.org/10.1016/s1097-2765(05)00077-8
https://doi.org/10.1016/s1097-2765(05)00077-8
Publikováno v:
Molecular and Biochemical Parasitology. 110:107-124
We present the first single cell-level analysis of digestive vacuolar pH for representative chloroquine resistant (strain Dd2) versus sensitive (strain HB3) malarial parasites. Human red blood cells harboring intact intraerythrocytic parasites were a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6be03b256ac5d0804328b9ceaa269238
https://doi.org/10.1016/s0166-6851(00)00261-9
https://doi.org/10.1016/s0166-6851(00)00261-9
Publikováno v:
Molecular and Biochemical Parasitology. 119:307-309
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::40da1aafe553de91e830e74f2852c5ce
https://doi.org/10.1016/s0166-6851(01)00406-6
https://doi.org/10.1016/s0166-6851(01)00406-6
Autor:
Paul D. Roepe, Lyann M. B. Ursos
Publikováno v:
ChemInform. 33
Malarial parasites remain a health problem of staggering proportions. Worldwide, they infect about 500 million, incapacitate tens of millions, and kill approximately 2.5 million (mostly children) annually. Four species infect humans, but most deaths
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2356aa2597a6f7eedf3a1f15c78bdc1c
https://doi.org/10.1002/chin.200245274
https://doi.org/10.1002/chin.200245274
Autor:
Paul D. Roepe, Sergey M. Dzekunov, Tyler N. Bennett, Amar Bir Singh Sidhu, Lyann M. B. Ursos, David A. Fidock, Andrew D. Kosar
Publikováno v:
Molecular and biochemical parasitology. 133(1)
Elucidating the altered physiology of various chloroquine resistant (CQR) strains of Plasmodium falciparum is essential for understanding the molecular basis of CQR. In this study, we have devised several new methods for analyzing digestive vacuolar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::95453708e3a5a868b49c2277db222136
https://pubmed.ncbi.nlm.nih.gov/14668017
https://pubmed.ncbi.nlm.nih.gov/14668017
Autor:
Lyann M. B. Ursos, Amar Bir Singh Sidhu, Rebecca A. Muhle, Hisashi Fujioka, Paul D. Roepe, Dominik Verdier-Pinard, Paul Horrocks, Karena L. Waller, David A. Fidock
Publikováno v:
The Journal of biological chemistry. 278(35)
Plasmodium falciparum malaria is increasingly difficult to treat and control due to the emergence of parasite resistance to the major antimalarials, notably chloroquine. Recent work has shown that the chloroquine resistance phenotype can be conferred
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4dda71a5467af3d966cba72d92120055
https://pubmed.ncbi.nlm.nih.gov/12813054
https://pubmed.ncbi.nlm.nih.gov/12813054
Autor:
Paul D. Roepe, Devin N. Sears, Alison Leed, Kateri H. DuBay, and Angel C. de Dios, Lyann M. B. Ursos
Publikováno v:
Biochemistry. 41(32)
Paramagnetic metal centers [such as Fe(III) found within ferriprotoporphyrin IX heme (FPIX)] exert through space effects on the relaxation rate of nearby proton spins that depend critically on the metal-proton distance. We have measured these effects
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::97b33f52c7197583d870b7785a33ad2e
https://pubmed.ncbi.nlm.nih.gov/12162739
https://pubmed.ncbi.nlm.nih.gov/12162739
Autor:
Takashi Nomura, Jianbing Mu, Paul D. Roepe, Hisashi Fujioka, Lyann M. B. Ursos, David A. Fidock, Thomas E. Wellems, Michael T. Ferdig, Xin-zhuan Su, Roland A. Cooper
Publikováno v:
Molecular pharmacology. 61(1)
Chloroquine resistance (CQR) in Plasmodium falciparum is associated with multiple mutations in the digestive vacuole membrane protein PfCRT. The chloroquine-sensitive (CQS) 106/1 line of P. falciparum has six of seven PfCRT mutations consistently fou
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b91d4beedc3633ef3dc8f0843b93a92
https://pubmed.ncbi.nlm.nih.gov/11752204
https://pubmed.ncbi.nlm.nih.gov/11752204