Derivatives of usnic acid inhibit broad range of influenza viruses and protect mice from lethal influenza infection

Autor: Shtro, AA, Zarubaev, VV, Luzina, OA, Sokolov, DN, Salakhutdinov, NF

Publikováno v: Antiviral Chemistry & Chemotherapy; August 2015, Vol. 24 Issue: 3-4 p92-98, 7p

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The Potential of Usnic-Acid-Based Thiazolo-Thiophenes as Inhibitors of the Main Protease of SARS-CoV-2 Viruses.

Autor: Yarovaya OI; Department of Medicinal Chemistry, N.N. Vorozhtsov Novosibirsk Institute of Organic Chemistry SB RAS, 630090 Novosibirsk, Russia., Filimonov AS; Department of Medicinal Chemistry, N.N. Vorozhtsov Novosibirsk Institute of Organic Chemistry SB RAS, 630090 Novosibirsk, Russia., Baev DS; Department of Medicinal Chemistry, N.N. Vorozhtsov Novosibirsk Institute of Organic Chemistry SB RAS, 630090 Novosibirsk, Russia.; Synchrotron Radiation Facility SKIF, G.K. Boreskov Institute of Catalysis SB RAS, 630559 Koltsovo, Russia., Borisevich SS; Synchrotron Radiation Facility SKIF, G.K. Boreskov Institute of Catalysis SB RAS, 630559 Koltsovo, Russia.; Laboratory of Chemical Physics, Ufa Institute of Chemistry, Ufa Federal Research Centre, 450078 Ufa, Russia., Zaykovskaya AV; State Research Center of Virology and Biotechnology VECTOR, Rospotrebnadzor, 630559 Koltsovo, Russia., Chirkova VY; Institute of Biology and Biotechnology, Altay State University, 656049 Barnaul, Russia., Marenina MK; Department of Medicinal Chemistry, N.N. Vorozhtsov Novosibirsk Institute of Organic Chemistry SB RAS, 630090 Novosibirsk, Russia., Meshkova YV; Department of Medicinal Chemistry, N.N. Vorozhtsov Novosibirsk Institute of Organic Chemistry SB RAS, 630090 Novosibirsk, Russia., Belenkaya SV; Department of Medicinal Chemistry, N.N. Vorozhtsov Novosibirsk Institute of Organic Chemistry SB RAS, 630090 Novosibirsk, Russia.; State Research Center of Virology and Biotechnology VECTOR, Rospotrebnadzor, 630559 Koltsovo, Russia., Shcherbakov DN; Department of Medicinal Chemistry, N.N. Vorozhtsov Novosibirsk Institute of Organic Chemistry SB RAS, 630090 Novosibirsk, Russia.; State Research Center of Virology and Biotechnology VECTOR, Rospotrebnadzor, 630559 Koltsovo, Russia.; Institute of Biology and Biotechnology, Altay State University, 656049 Barnaul, Russia., Gureev MA; Laboratory of Bio- and Cheminformatics, St. Petersburg School of Physics, Mathematics and Computer Science, HSE University, 194100 St. Peterburg, Russia., Luzina OA; Department of Medicinal Chemistry, N.N. Vorozhtsov Novosibirsk Institute of Organic Chemistry SB RAS, 630090 Novosibirsk, Russia., Pyankov OV; State Research Center of Virology and Biotechnology VECTOR, Rospotrebnadzor, 630559 Koltsovo, Russia., Salakhutdinov NF; Department of Medicinal Chemistry, N.N. Vorozhtsov Novosibirsk Institute of Organic Chemistry SB RAS, 630090 Novosibirsk, Russia., Khvostov MV; Department of Medicinal Chemistry, N.N. Vorozhtsov Novosibirsk Institute of Organic Chemistry SB RAS, 630090 Novosibirsk, Russia.

Publikováno v: Viruses [Viruses] 2024 Jan 31; Vol. 16 (2). Date of Electronic Publication: 2024 Jan 31.

Pharmacokinetic study of Tdp1 inhibitor resulted in a significant increase in antitumor effect in the treatment of Lewis lung carcinoma in mice by its combination with topotecan.

Autor: Okhina AA; N. N. Vorozhtsov Novosibirsk Institute of Organic Chemistry of the Siberian Branch of Russian Academy of Sciences, Lavrent'ev ave., 9, Novosibirsk 630090, Russia; Novosibirsk State University, Pirogov St., 2, Novosibirsk 630090, Russia., Kornienko TE; Institute of Chemical Biology and Fundamental Medicine of the Siberian Branch of Russian Academy of Sciences, Lavrent'ev ave., 8, Novosibirsk 630090, Russia., Rogachev AD; N. N. Vorozhtsov Novosibirsk Institute of Organic Chemistry of the Siberian Branch of Russian Academy of Sciences, Lavrent'ev ave., 9, Novosibirsk 630090, Russia; Novosibirsk State University, Pirogov St., 2, Novosibirsk 630090, Russia., Luzina OA; N. N. Vorozhtsov Novosibirsk Institute of Organic Chemistry of the Siberian Branch of Russian Academy of Sciences, Lavrent'ev ave., 9, Novosibirsk 630090, Russia., Popova NA; Novosibirsk State University, Pirogov St., 2, Novosibirsk 630090, Russia; Institute of Cytology and Genetics of the Siberian Branch of the Russian Academy of Sciences, Lavrent'ev ave., 10, Novosibirsk 630090, Russia., Nikolin VP; Institute of Cytology and Genetics of the Siberian Branch of the Russian Academy of Sciences, Lavrent'ev ave., 10, Novosibirsk 630090, Russia., Zakharenko AL; Institute of Chemical Biology and Fundamental Medicine of the Siberian Branch of Russian Academy of Sciences, Lavrent'ev ave., 8, Novosibirsk 630090, Russia., Dyrkheeva NS; Institute of Chemical Biology and Fundamental Medicine of the Siberian Branch of Russian Academy of Sciences, Lavrent'ev ave., 8, Novosibirsk 630090, Russia., Pokrovsky AG; Novosibirsk State University, Pirogov St., 2, Novosibirsk 630090, Russia., Salakhutdinov NF; N. N. Vorozhtsov Novosibirsk Institute of Organic Chemistry of the Siberian Branch of Russian Academy of Sciences, Lavrent'ev ave., 9, Novosibirsk 630090, Russia., Lavrik OI; Novosibirsk State University, Pirogov St., 2, Novosibirsk 630090, Russia; Institute of Chemical Biology and Fundamental Medicine of the Siberian Branch of Russian Academy of Sciences, Lavrent'ev ave., 8, Novosibirsk 630090, Russia. Electronic address: lavrik@niboch.nsc.ru.

Publikováno v: Journal of pharmaceutical and biomedical analysis [J Pharm Biomed Anal] 2023 Nov 30; Vol. 236, pp. 115731. Date of Electronic Publication: 2023 Sep 18.