Suppression of liquid-liquid phase separation by 1,6-hexanediol partially compromises the 3D genome organization in living cells.

Autor: Ulianov SV; Institute of Gene Biology Russian Academy of Science, 119334 Moscow, Russia.; Faculty of Biology, Lomonosov Moscow State University, 119992 Moscow, Russia., Velichko AK; Institute of Gene Biology Russian Academy of Science, 119334 Moscow, Russia.; Center for Precision Genome Editing and Genetic Technologies for Biomedicine, Institute of Gene Biology Russian Academy of Sciences, 119334 Moscow, Russia.; Institute for Translational Medicine and Biotechnology, Sechenov First Moscow State Medical University, 119991 Moscow, Russia., Magnitov MD; Institute of Gene Biology Russian Academy of Science, 119334 Moscow, Russia.; Center for Precision Genome Editing and Genetic Technologies for Biomedicine, Institute of Gene Biology Russian Academy of Sciences, 119334 Moscow, Russia.; Department of Biological and Medical Physics, Moscow Institute of Physics and Technology (National Research University), 141701 Dolgoprudny, Russia., Luzhin AV; Institute of Gene Biology Russian Academy of Science, 119334 Moscow, Russia.; Center for Precision Genome Editing and Genetic Technologies for Biomedicine, Institute of Gene Biology Russian Academy of Sciences, 119334 Moscow, Russia., Golov AK; Institute of Gene Biology Russian Academy of Science, 119334 Moscow, Russia., Ovsyannikova N; A.N. Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, 119992 Moscow, Russia., Kireev II; A.N. Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, 119992 Moscow, Russia.; V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology, and Perinatology, 117997 Moscow, Russia., Gavrikov AS; Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, 117997 Moscow, Russia., Mishin AS; Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, 117997 Moscow, Russia., Garaev AK; Institute of Gene Biology Russian Academy of Science, 119334 Moscow, Russia., Tyakht AV; Institute of Gene Biology Russian Academy of Science, 119334 Moscow, Russia.; Center for Precision Genome Editing and Genetic Technologies for Biomedicine, Institute of Gene Biology Russian Academy of Sciences, 119334 Moscow, Russia., Gavrilov AA; Institute of Gene Biology Russian Academy of Science, 119334 Moscow, Russia.; Center for Precision Genome Editing and Genetic Technologies for Biomedicine, Institute of Gene Biology Russian Academy of Sciences, 119334 Moscow, Russia., Kantidze OL; Institute of Gene Biology Russian Academy of Science, 119334 Moscow, Russia., Razin SV; Institute of Gene Biology Russian Academy of Science, 119334 Moscow, Russia.

Publikováno v: Nucleic acids research [Nucleic Acids Res] 2021 Oct 11; Vol. 49 (18), pp. 10524-10541.

DNA G-Quadruplexes Contribute to CTCF Recruitment.

Autor: Tikhonova P; Federal Research and Clinical Center of Physical-Chemical Medicine of Federal Medical Biological Agency, 119435 Moscow, Russia., Pavlova I; Federal Research and Clinical Center of Physical-Chemical Medicine of Federal Medical Biological Agency, 119435 Moscow, Russia.; Moscow Institute of Physics and Technology, 141701 Dolgoprudny, Russia., Isaakova E; Federal Research and Clinical Center of Physical-Chemical Medicine of Federal Medical Biological Agency, 119435 Moscow, Russia., Tsvetkov V; A.V. Topchiev Institute of Petrochemical Synthesis RAS, 119071 Moscow, Russia.; WCRC Russia 'Digital Biodesign and Personalized Healthcare', Sechenov First Moscow State Medical University, 119146 Moscow, Russia., Bogomazova A; Federal Research and Clinical Center of Physical-Chemical Medicine of Federal Medical Biological Agency, 119435 Moscow, Russia.; Center for Precision Genome Editing and Genetic Technologies for Biomedicine, Federal Research and Clinical Center of Physical-Chemical Medicine of Federal Medical Biological Agency, 119435 Moscow, Russia., Vedekhina T; Federal Research and Clinical Center of Physical-Chemical Medicine of Federal Medical Biological Agency, 119435 Moscow, Russia., Luzhin AV; Institute of Gene Biology Russian Academy of Sciences, 119334 Moscow, Russia., Sultanov R; Federal Research and Clinical Center of Physical-Chemical Medicine of Federal Medical Biological Agency, 119435 Moscow, Russia.; Center for Precision Genome Editing and Genetic Technologies for Biomedicine, Federal Research and Clinical Center of Physical-Chemical Medicine of Federal Medical Biological Agency, 119435 Moscow, Russia., Severov V; Federal Research and Clinical Center of Physical-Chemical Medicine of Federal Medical Biological Agency, 119435 Moscow, Russia., Klimina K; Federal Research and Clinical Center of Physical-Chemical Medicine of Federal Medical Biological Agency, 119435 Moscow, Russia., Kantidze OL; Institute of Gene Biology Russian Academy of Sciences, 119334 Moscow, Russia., Pozmogova G; Federal Research and Clinical Center of Physical-Chemical Medicine of Federal Medical Biological Agency, 119435 Moscow, Russia., Lagarkova M; Federal Research and Clinical Center of Physical-Chemical Medicine of Federal Medical Biological Agency, 119435 Moscow, Russia.; Center for Precision Genome Editing and Genetic Technologies for Biomedicine, Federal Research and Clinical Center of Physical-Chemical Medicine of Federal Medical Biological Agency, 119435 Moscow, Russia., Varizhuk A; Moscow Institute of Physics and Technology, 141701 Dolgoprudny, Russia.; Center for Precision Genome Editing and Genetic Technologies for Biomedicine, Federal Research and Clinical Center of Physical-Chemical Medicine of Federal Medical Biological Agency, 119435 Moscow, Russia.

Publikováno v: International journal of molecular sciences [Int J Mol Sci] 2021 Jun 30; Vol. 22 (13). Date of Electronic Publication: 2021 Jun 30.

Genetically Encoded Fluorescent Sensor for Poly-ADP-Ribose.

Autor: Serebrovskaya EO; Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Miklukho-Maklaya 16/10, 117997 Moscow, Russia., Podvalnaya NM; Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Miklukho-Maklaya 16/10, 117997 Moscow, Russia.; Institute of Molecular Genetics, Kurchatova Sq. 2, 123182 Moscow, Russia., Dudenkova VV; Institute of Experimental Oncology and Biomedical Technologies, Privolzhsky Research Medical University, Minin and Pozharsky Sq. 10/1, 603005 Nizhny Novgorod, Russia., Efremova AS; Institute of Molecular Genetics, Kurchatova Sq. 2, 123182 Moscow, Russia., Gurskaya NG; Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Miklukho-Maklaya 16/10, 117997 Moscow, Russia.; Institute of Translational Medicine, Pirogov Russian National Research Medical University, Ostrovityanova 1, 117997 Moscow, Russia., Gorbachev DA; Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Miklukho-Maklaya 16/10, 117997 Moscow, Russia., Luzhin AV; Institute of Gene Biology, Vavilova 34/5, 119334 Moscow, Russia., Kantidze OL; Institute of Gene Biology, Vavilova 34/5, 119334 Moscow, Russia., Zagaynova EV; Institute of Experimental Oncology and Biomedical Technologies, Privolzhsky Research Medical University, Minin and Pozharsky Sq. 10/1, 603005 Nizhny Novgorod, Russia.; Lobachevsky State University of Nizhny Novgorod, Gagarin Ave. 23, 603950 Nizhny Novgorod, Russia., Shram SI; Institute of Molecular Genetics, Kurchatova Sq. 2, 123182 Moscow, Russia., Lukyanov KA; Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Miklukho-Maklaya 16/10, 117997 Moscow, Russia.

Publikováno v: International journal of molecular sciences [Int J Mol Sci] 2020 Jul 15; Vol. 21 (14). Date of Electronic Publication: 2020 Jul 15.

Chromatin Trapping of Factors Involved in DNA Replication and Repair Underlies Heat-Induced Radio- and Chemosensitization.

Autor: Luzhin AV; Institute of Gene Biology Russian Academy of Science, 119334 Moscow, Russia.; Center for Precision Genome Editing and Genetic Technologies for Biomedicine, Institute of Gene Biology Russian Academy of Sciences, 119334 Moscow, Russia., Avanesyan B; Institute of Gene Biology Russian Academy of Science, 119334 Moscow, Russia., Velichko AK; Institute of Gene Biology Russian Academy of Science, 119334 Moscow, Russia.; Center for Precision Genome Editing and Genetic Technologies for Biomedicine, Institute of Gene Biology Russian Academy of Sciences, 119334 Moscow, Russia.; Institute for Translational Medicine and Biotechnology, Sechenov First Moscow State Medical University, 119991 Moscow, Russia., Shender VO; Center for Precision Genome Editing and Genetic Technologies for Biomedicine, Federal Research and Clinical Center of Physical-Chemical Medicine of Federal Medical Biological Agency, 119435 Moscow, Russia.; Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry of the Russian Academy of Sciences, 117997 Moscow, Russia., Ovsyannikova N; A.N. Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, 119992 Moscow, Russia., Arapidi GP; Center for Precision Genome Editing and Genetic Technologies for Biomedicine, Federal Research and Clinical Center of Physical-Chemical Medicine of Federal Medical Biological Agency, 119435 Moscow, Russia.; Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry of the Russian Academy of Sciences, 117997 Moscow, Russia.; Moscow Institute of Physics and Technology (State University), 141701 Moscow, Russia., Shnaider PV; Center for Precision Genome Editing and Genetic Technologies for Biomedicine, Federal Research and Clinical Center of Physical-Chemical Medicine of Federal Medical Biological Agency, 119435 Moscow, Russia., Petrova NV; Institute of Gene Biology Russian Academy of Science, 119334 Moscow, Russia., Kireev II; A.N. Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, 119992 Moscow, Russia.; V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology, and Perinatology, 117997 Moscow, Russia., Razin SV; Institute of Gene Biology Russian Academy of Science, 119334 Moscow, Russia.; Department of Biology, Lomonosov Moscow State University, 119992 Moscow, Russia., Kantidze OL; Institute of Gene Biology Russian Academy of Science, 119334 Moscow, Russia.

Publikováno v: Cells [Cells] 2020 Jun 08; Vol. 9 (6). Date of Electronic Publication: 2020 Jun 08.

Hypoosmotic stress induces R loop formation in nucleoli and ATR/ATM-dependent silencing of nucleolar transcription.

Autor: Velichko AK; Laboratory of Genome Stability, Institute of Gene Biology, Russian Academy of Sciences, 119334 Moscow, Russia.; Institute for Translational Medicine and Biotechnology, Sechenov First Moscow State Medical University, 119991 Moscow, Russia., Petrova NV; Laboratory of Genome Stability, Institute of Gene Biology, Russian Academy of Sciences, 119334 Moscow, Russia., Luzhin AV; Laboratory of Genome Stability, Institute of Gene Biology, Russian Academy of Sciences, 119334 Moscow, Russia., Strelkova OS; A.N. Belozersky Institute of Physico-Chemical Biology, Moscow State University, 119992 Moscow, Russia., Ovsyannikova N; A.N. Belozersky Institute of Physico-Chemical Biology, Moscow State University, 119992 Moscow, Russia., Kireev II; A.N. Belozersky Institute of Physico-Chemical Biology, Moscow State University, 119992 Moscow, Russia.; V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology, and Perinatology, 117997 Moscow, Russia., Petrova NV; Laboratory of Structural and Functional Organization of Chromosomes, Institute of Gene Biology, Russian Academy of Sciences, 119334 Moscow, Russia., Razin SV; Laboratory of Structural and Functional Organization of Chromosomes, Institute of Gene Biology, Russian Academy of Sciences, 119334 Moscow, Russia.; Department of Molecular Biology, Moscow State University, 119234 Moscow, Russia.; LFR2O, Institute Gustave Roussy, F-94805 Villejuif, France., Kantidze OL; Laboratory of Genome Stability, Institute of Gene Biology, Russian Academy of Sciences, 119334 Moscow, Russia.; LFR2O, Institute Gustave Roussy, F-94805 Villejuif, France.

Publikováno v: Nucleic acids research [Nucleic Acids Res] 2019 Jul 26; Vol. 47 (13), pp. 6811-6825.