Zobrazeno 1 - 10
of 66
pro vyhledávání: '"Luzelena Caro"'
Autor:
Jia Yao Phuah, Brian M. Maas, Aimin Tang, Ying Zhang, Luzelena Caro, Radha A. Railkar, Michael D. Swanson, Yu Cao, Hankun Li, Brad Roadcap, Andrew P. Catchpole, Antonios O. Aliprantis, Kalpit A. Vora
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 169, Iss , Pp 115851- (2023)
Background: Clesrovimab (MK-1654) is an investigational, half-life extended human monoclonal antibody (mAb) against RSV F glycoprotein in clinical trials as a prophylactic agent against RSV infection for infants. Methods: This adult study measured cl
Externí odkaz:
https://doaj.org/article/6074672de6f4415ab83703ee8e9116c9
Autor:
Yuji Orito, Naoyuki Otani, Yuki Matsumoto, Katsukuni Fujimoto, Nobuyuki Oshima, Brian M. Maas, Luzelena Caro, Antonios O. Aliprantis, Kara S. Cox, Osamu Tokumaru, Masaaki Kodama, Hideo Kudo, Hiromitsu Imai, Naoto Uemura
Publikováno v:
Clinical and Translational Science, Vol 15, Iss 7, Pp 1753-1763 (2022)
Abstract Respiratory syncytial virus (RSV) is the leading cause of lower respiratory tract infection among all infants worldwide and remains a significant cause of morbidity and mortality. To address this unmet medical need, MK‐1654, a half‐life
Externí odkaz:
https://doaj.org/article/e40accb32f454104982f83fe7c931136
Autor:
Regino P. Gonzalez-Peralta, Stefan Wirth, Robert H. Squires, Frauke Mutschler, Thomas Lang, Malgorzata Pawlowska, Wojciech Sluzewski, Ewa Majda-Stanislawska, Bjorn Fischler, William F. Balistreri, Maureen M. Jonas, Niviann Blondet, Philip Rosenthal, Naim Alkhouri, Rene Romero, Anjana Grandhi, Patricia Castronuovo, Luzelena Caro, Lihong Du, Daniel I.S. Rosenbloom, Barbara A. Haber
Publikováno v:
Hepatology Communications, Vol 7, Iss 3, Pp e0031-e0031 (2023)
Background:. Approximately 3.5 million children and adolescents worldwide are chronically infected with HCV. This study uses pharmacokinetic modeling to identify pediatric doses of elbasvir/grazoprevir (EBR/GZR) that achieve plasma concentrations sim
Externí odkaz:
https://doaj.org/article/0efa3d17ae6a4abb80653349bdc6fcd4
Publikováno v:
Clinical and Translational Science, Vol 14, Iss 6, Pp 2348-2359 (2021)
Abstract Coronavirus disease 2019 (COVID‐19) global pandemic is caused by severe acute respiratory syndrome‐coronavirus 2 (SARS‐CoV‐2) viral infection, which can lead to pneumonia, lung injury, and death in susceptible populations. Understand
Externí odkaz:
https://doaj.org/article/1ae0f6eb4842422aa0440c30df295216
Autor:
Brian M. Maas, Jos Lommerse, Nele Plock, Radha A. Railkar, S.Y. Amy Cheung, Luzelena Caro, Jingxian Chen, Wen Liu, Ying Zhang, Qinlei Huang, Wei Gao, Li Qin, Jie Meng, Han Witjes, Emilie Schindler, Benjamin Guiastrennec, Francesco Bellanti, Daniel S. Spellman, Brad Roadcap, Mariya Kalinova, Juin Fok-Seang, Andrew P. Catchpole, Amy S. Espeseth, S. Aubrey Stoch, Eseng Lai, Kalpit A. Vora, Antonios O. Aliprantis, Jeffrey R. Sachs
Publikováno v:
EBioMedicine, Vol 73, Iss , Pp 103651- (2021)
Background: Neutralizing mAbs can prevent communicable viral diseases. MK-1654 is a respiratory syncytial virus (RSV) F glycoprotein neutralizing monoclonal antibody (mAb) under development to prevent RSV infection in infants. Development and validat
Externí odkaz:
https://doaj.org/article/29110f874edd46dea00e331b42ac8484
Autor:
Nancy Reau, Michael N. Robertson, Hwa‐Ping Feng, Luzelena Caro, Wendy W. Yeh, Bach‐Yen T. Nguyen, Janice Wahl, Eliav Barr, Peggy Hwang, Stephanie O. Klopfer
Publikováno v:
Hepatology Communications, Vol 1, Iss 8, Pp 757-764 (2017)
Concomitant proton pump inhibitor (PPI) use reduces plasma concentrations of certain nonstructural protein 5A inhibitors, which are key components of modern hepatitis C infection (HCV) treatments. These reduced concentrations may decrease efficacy, l
Externí odkaz:
https://doaj.org/article/4c7209c5aab146baa45be70dea5608b3
Autor:
Felicia L. Sterman, Jacob P. Lalezari, Ula M. Kowalczyk, David W. Main, Edward M. Grant, Luzelena Caro, Cassie M. Manning, Rochelle L. Burke
Publikováno v:
AIDS. 37:1057-1064
Autor:
Christine Fandozzi, Deborah Panebianco, Luzelena Caro, Dennis Wolford, Zifang Guo, Iain P. Fraser, Dennis Swearingen, Vanessa Levine, Hwa-Ping Feng, Thomayant Prueksaritanont, Joan R. Butterton, Marian Iwamoto, Wendy W. Yeh
Publikováno v:
Clinical Drug Investigation. 41:133-147
Many people infected with hepatitis C virus have comorbidities, including hypercholesterolemia, that are treated with statins. In this study, we evaluated the drug–drug interaction potential of the hepatitis C virus inhibitors elbasvir (EBR) and gr
Autor:
Adedayo Adedoyin, Zhen Zeng, Jan J. De Waele, Elaine Gadzicki, Brian Yu, Elizabeth G. Rhee, David P. Nicolau, Luzelena Caro, Kajal B. Larson, Joseph L. Kuti
Publikováno v:
Journal of Antimicrobial Chemotherapy
ObjectivesCeftolozane/tazobactam is approved for hospital-acquired/ventilator-associated bacterial pneumonia at double the dose (i.e. 2 g/1 g) recommended for other indications. We evaluated the bronchopulmonary pharmacokinetic/pharmacodynamic profil
Autor:
Iain P. Fraser, Larissa Wenning, Eric Mangin, Bonnie J. Howell, Christine Fandozzi, Jill Maxwell, W. Gao, Radha Railkar, Kristien Van Dyck, Chris Chung, Norah J. Shire, Andrew H. Talal, Melanie Anderson, Luzelena Caro, Serghei Popa, Andrea L. Webber, André M. M. Miltenburg, S. Aubrey Stoch
Publikováno v:
Clinical Pharmacology & Therapeutics. 107:1325-1333
Fine-needle aspiration (FNA) for serial hepatic sampling may be an efficient and less invasive alternative to core needle biopsy (CNB), the current standard for liver tissue sampling. In this randomized, open-label trial in 31 participants with hepat