Oncological transformation in vitro of hepatic progenitor cell lines isolated from adult mice

Autor: Rocío Olivera-Salazar, Mariano García-Arranz, Aránzazu Sánchez, Susana Olmedillas-López, Luz Vega-Clemente, Luis Javier Serrano, Blanca Herrera, Damián García-Olmo

Publikováno v: Scientific Reports, Vol 12, Iss 1, Pp 1-12 (2022)

Abstract Colorectal cancer cells can transfer the oncogene KRAS to distant cells, predisposing them to malignant transformation (Genometastasis Theory). This process could contribute to liver metastasis; besides, hepatic progenitor cells (HPCs) have

Externí odkaz: https://doaj.org/article/5a81740dc5854d51a91be1049046e51a

Main histological parameters to be evaluated in an experimental model of myocardial infarct treated by stem cells on pigs

Autor: Soledad García Gómez-Heras, Carlota Largo, Jose Luis Larrea, Luz Vega-Clemente, Miguel Calderón Flores, Daniel Ruiz-Pérez, Damián García-Olmo, Mariano García-Arranz

Publikováno v: PeerJ, Vol 7, p e7160 (2019)

Myocardial infarction has been carefully studied in numerous experimental models. Most of these models are based on electrophysiological and functional data, and pay less attention to histological discoveries. During the last decade, treatment using

Externí odkaz: https://doaj.org/article/daa3cdce3f954a20b4abdc768d166c06

Toxicity Study in a Pig Model of Intraperitoneal Collagenase as an 'Enzymatic Scalpel' Directed to Breaks Stroma in Order to Generate a New Perspective for Peritoneal Carcinomatosis Approach. An Experimental Research

Autor: Javier Barambio, Luz Vega-Clemente, Pedro Villarejo-Campos, Héctor Guadalajara, Damian Garcia-Olmo, Soledad García Gómez-Heras, Mariano García-Arranz

Background This study aimed to measure the toxicity resulting from collagenase administration to the peritoneal cavity in a pig model as a preliminary step to break down the stroma surrounding tumors. Methods Eight pigs were treated with 2 different

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c9e07c38de37393a600e0083408b96a
https://doi.org/10.21203/rs.3.rs-970756/v1

Intraperitoneal collagenase as a novel therapeutic approach in an experimental model of colorectal peritoneal carcinomatosis

Autor: Mariano García-Arranz, Damián García-Olmo, P Villarejo Campos, Luz Vega-Clemente, Héctor Guadalajara, Susana Olmedillas-López, S Garcia Gomez-Heras, J. Barambio

Publikováno v: Scientific Reports
Scientific Reports, Vol 11, Iss 1, Pp 1-8 (2021)

The usefulness of local collagenase in therapeutic approaches to solid tumors has been tested recently. In this study, we evaluate the safety and efficacy of intraperitoneal collagenase associated or not to mitomycin for treatment of colorectal perit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad93c5d15e2c843cfb3b2a8c153f6402
https://doi.org/10.1038/s41598-020-79721-0

Rat model of anal sphincter injury and two approaches for stem cell administration

Autor: Ana Carabias-Orgaz, Damián García-Olmo, T. Georgiev-Hristov, Jacobo Trébol, Luz Vega-Clemente, Mariano García-Arranz, Ignacio Garcia-Gomez

Publikováno v: Biblos-e Archivo. Repositorio Institucional de la UAM
instname
World Journal of Stem Cells
Repositorio Institucional de la Consejería de Sanidad de la Comunidad de Madrid
Consejería de Sanidad de la Comunidad de Madrid
Biblos-e Archivo: Repositorio Institucional de la UAM
Universidad Autónoma de Madrid

Aim To establish a rat model of anal sphincter injury and test different systems to provide stem cells to injured area. Methods Adipose-derived stem cells (ASCs) were isolated from BDIX rats and were transfected with green fluorescent protein (GFP) f

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::967b12c8ed43adb68dcefb94239cd22d
http://hdl.handle.net/10486/681684