Zobrazeno 1 - 10
of 39
pro vyhledávání: '"Luz D Orozco"'
Autor:
Christoph Daniel Rau, Nicholas eWisniewski, Luz D Orozco, Brian eBennett, James Nathaniel Weiss, Aldons Jake Lusis
Publikováno v:
Frontiers in Genetics, Vol 4 (2013)
Background: Network construction and analysis algorithms provide scientists with the ability to sift through high-throughput biological outputs, such as transcription microarrays, for small groups of genes (modules) that are relevant for further rese
Externí odkaz:
https://doaj.org/article/dbd33904b8f64c11a04ec818d0bffaba
Autor:
Melissa K. Jones, Luz D. Orozco, Han Qin, Tom Truong, Patrick Caplazi, Justin Elstrott, Zora Modrusan, Shawnta Y. Chaney, Marion Jeanne
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 11 (2023)
Rare DRAM2 coding variants cause retinal dystrophy with early macular involvement via unknown mechanisms. We found that DRAM2 is ubiquitously expressed in the human eye and expression changes were observed in eyes with more common maculopathy such as
Externí odkaz:
https://doaj.org/article/4d5ae22863834591822d2aa0e0991e50
Autor:
Luz D. Orozco, Hsu-Hsin Chen, Christian Cox, Kenneth J. Katschke, Jr., Rommel Arceo, Carmina Espiritu, Patrick Caplazi, Sarajane Saturnio Nghiem, Ying-Jiun Chen, Zora Modrusan, Amy Dressen, Leonard D. Goldstein, Christine Clarke, Tushar Bhangale, Brian Yaspan, Marion Jeanne, Michael J. Townsend, Menno van Lookeren Campagne, Jason A. Hackney
Publikováno v:
Cell Reports, Vol 42, Iss 3, Pp 112298- (2023)
Externí odkaz:
https://doaj.org/article/50149307557045f491296fd14962a70c
Autor:
Luz D. Orozco, Leah Owen, Jeffrey Hofmann, Amy D. Stockwell, Jianhua Tao, Susan Haller, Vineeth T. Mukundan, Christine Clarke, Jessica Lund, Akshayalakshmi Sridhar, Julie L. Barr, Rylee A. Zavala, Elijah C. Graves, Charles Zhang, Nadine Husami, Robert Finley, Elizabeth Au, John H. Lillvis, Michael H. Farkas, Akbar Shakoor, Richard M. Sherva, Ivana K. Kim, Joshua S. Kaminker, Michael J. Townsend, Lindsay A. Farrer, Brian L. Yaspan, Hsu-Hsin Chen, Margaret M. DeAngelis
Age-related Macular Degeneration (AMD) is a leading cause of blindness, affecting 200 million people worldwide. We present a comprehensive molecular atlas for different stages of AMD.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a07fcd58dd2422fa1d90174ae6aa8727
Autor:
Luz D. Orozco, Leah A. Owen, Jeffrey Hofmann, Amy D. Stockwell, Jianhua Tao, Susan Haller, Vineeth T. Mukundan, Christine Clarke, Jessica Lund, Akshayalakshmi Sridhar, Oleg Mayba, Julie L. Barr, Rylee A. Zavala, Elijah C. Graves, Charles Zhang, Nadine Husami, Robert Finley, Elizabeth Au, John H. Lillvis, Michael H. Farkas, Akbar Shakoor, Richard Sherva, Ivana K. Kim, Joshua S. Kaminker, Michael J. Townsend, Lindsay A. Farrer, Brian L. Yaspan, Hsu-Hsin Chen, Margaret M. DeAngelis
Publikováno v:
Cell Genomics. :100302
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f5019f5766a9bcf8ae4ba1059a766b93
https://doi.org/10.1016/j.xgen.2023.100302
https://doi.org/10.1016/j.xgen.2023.100302
Autor:
Frank Wagner, John C Mansfield, Annemarie N Lekkerkerker, Yehong Wang, Mary Keir, Ajit Dash, Brandon Butcher, Brandon Harder, Luz D Orozco, Jordan S Mar, Hao Chen, Michael E Rothenberg
Publikováno v:
Gut. :gutjnl-2022
BackgroundThe interleukin-22 cytokine (IL-22) has demonstrated efficacy in preclinical colitis models with non-immunosuppressive mechanism of action. Efmarodocokin alfa (UTTR1147A) is a fusion protein agonist that links IL-22 to the crystallisable fr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::99867f36924e2c27e9eb200a19c1ef7b
https://doi.org/10.1136/gutjnl-2022-328387
https://doi.org/10.1136/gutjnl-2022-328387
Autor:
Anneke I. den Hollander, Robert F. Mullins, Luz D. Orozco, Andrew P. Voigt, Hsu-Hsin Chen, Tobias Strunz, Felix Grassmann, Jonathan L. Haines, Jonas J.W. Kuiper, Santa J. Tumminia, Rando Allikmets, Gregory S. Hageman, Dwight Stambolian, Caroline C.W. Klaver, Jef D. Boeke, Hao Chen, Lee Honigberg, Suresh Katti, Kelly A. Frazer, Bernhard H.F. Weber, Michael B. Gorin
Publikováno v:
Experimental Eye Research, 225
Experimental Eye Research, 225:109248. Academic Press
Experimental Eye Research, 225:109248. Academic Press
Genomic studies in age-related macular degeneration (AMD) have identified genetic variants that account for the majority of AMD risk. An important next step is to understand the functional consequences and downstream effects of the identified AMD-ass
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d947d06bcb1649a9c0ededef4e755a54
https://doi.org/10.1016/j.exer.2022.109248
https://doi.org/10.1016/j.exer.2022.109248
Autor:
Tangsheng Yi, Allen Nguyen, Azra Hassanali, Bingbing Dai, Kai-Hui Sun, Swati Tole, Jason A. Hackney, Mary E. Keir, Jacqueline McBride, Luz D. Orozco, Young S Oh, Akiko Chai, Aida Habtezion, Alexis Scherl, John Gubatan, Monika Deswal, Justin Elstrott, Zaineb Sharafali, Alvin Gogineni, Ma Somsouk, Ryan Ichikawa, William A. Faubion, Zora Modrusan
Publikováno v:
Cell Reports Medicine
Cell reports. Medicine, vol 2, iss 8
Cell reports. Medicine, vol 2, iss 8
Summary Anti-integrins are therapeutically effective for inflammatory bowel disease, yet the relative contribution of α4β7 and αEβ7 to gut lymphocyte trafficking is not fully elucidated. Here, we evaluate the effect of α4β7 and αEβ7 blockade
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::54407c0a1f31d278b0cf9f4ef1c4dec8
http://europepmc.org/articles/PMC8385326
http://europepmc.org/articles/PMC8385326
Autor:
Kelly M. Loyet, Neil N. Trivedi, Racquel Corpuz, Brian L. Yaspan, Tracy Staton, Henry R. Maun, Erin H. Christensen, Kathila R. Alatsis, Xiumin Wu, Michael T. Lipari, Yvonne Franke, Mark S. Dennis, Daniel Kirchhofer, Wyne P. Lee, Rahul Ahuja, Xiaocheng Chen, Ashley Morando, Diana Chang, James T. Koerber, Aija Kusi, Joseph R. Arron, John Liu, Guiquan Jia, Juan Zhang, Janet Jackman, Ping Wu, George H. Caughey, Yan Wu, Rajesh Vij, Luz D. Orozco, Lawrence B. Schwartz, Benjamin T. Walters, Charles Eigenbrot, Prescott G. Woodruff, Lawren C. Wu, David F. Choy, Robert A. Lazarus, Meire Bremer, Amy Dressen, Magda Babina, Tangsheng Yi, Savita Ubhayakar, Xiaorong Liang, Jeff Lutman, Siddharth Sukumaran, Jason A. Hackney, John V. Fahy, Julie Q. Hang, Cary D. Austin, Manda Wong
Publikováno v:
Cell, vol 179, iss 2
Cell
Cell
Severe asthma patients with low type 2 inflammation derive less clinical benefit from therapies targeting type 2 cytokines and have significant unmet medical needs. We show that mast cell tryptase is elevated in severe asthma patients, correlating wi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f8c0946c02d2066eb05676694e454e0e
https://escholarship.org/uc/item/8pf5p52n
https://escholarship.org/uc/item/8pf5p52n
Autor:
Sarajane Saturnio Nghiem, Christian Cox, Luz D. Orozco, Christine Clarke, Brian L. Yaspan, Tushar Bhangale, Michael J. Townsend, Ying-Jiun Chen, Marion Jeanne, Hsu-Hsin Chen, Carmina Espiritu, Kenneth J. Katschke, Zora Modrusan, Patrick Caplazi, Leonard D. Goldstein, Rommel Arceo, Menno van Lookeren Campagne, Jason A. Hackney, Amy Dressen
Publikováno v:
Cell Reports, Vol 30, Iss 4, Pp 1246-1259.e6 (2020)
Summary: Age-related macular degeneration (AMD) is a leading cause of vision loss. To better understand disease pathogenesis and identify causal genes in GWAS loci for AMD risk, we present a comprehensive database of human retina and retinal pigment
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6deb44d92a86a9d08a1d957f453cd48a
https://doi.org/10.1016/j.celrep.2019.12.082
https://doi.org/10.1016/j.celrep.2019.12.082