Zobrazeno 1 - 10
of 59
pro vyhledávání: '"Luyi Sen"'
Autor:
Allison Linh Lam, H. Furukawa, David B. Stout, Sanjiv S. Gambhir, Hillel Laks, Guanggen Cui, Luyi Sen
Publikováno v:
Molecular Therapy. 12:49-57
We developed a clinically applicable approach for noninvasive monitoring of reporter–therapeutic linked gene expression in the whole heart of large animals using PET imaging and further validated the efficacy and cardiac adverse effects of reporter
Publikováno v:
The Journal of Immunology. 174:6983-6992
Localized gene transfer has the potential to introduce immunosuppressive molecules only into the transplanted allograft, which would limit systemic side effects, and prolong allograft survival. However, an applicable gene transfer strategy is not ava
Publikováno v:
American Journal of Physiology-Heart and Circulatory Physiology. 285:H964-H973
Activation-induced cell death and cytokine deprivation are demonstrated by peripheral T cell populations at the conclusion of natural immune responses, and each of these processes is modulated by the immunosuppressive cytokine interleukin (IL)-10 in
Publikováno v:
Transplantation. 76:137-142
Background. The precise incidence and cause of atrioventricular block (AVB) after heart transplantation remain uncertain. Methods and Results. After surgery, immediate and follow-up electrocardiograms from 1,047 consecutive patients who underwent hea
Publikováno v:
American Journal of Physiology-Heart and Circulatory Physiology. 283:H2119-H2129
To evaluate the effects of liothyronine (3,5,3′-triiodo-l-thyronine, T3) on Na+ channel current ( I Na) properties, I Na was recorded in adult guinea pig ventricular myocytes. T3 (1 nM) acutely increased whole cell I Na and shifted the steady-state
Autor:
Thomas H. Tung, Guanggen Cui, Luyi Sen, Benjamin M. Sacks, Anthony Arellano-Kruse, Hillel Laks, Kiyohiro Oshima
Publikováno v:
Transplantation. 73:1019-1026
We hypothesized that localized IL-10 gene transfer can induce alloreactive T cell apoptosis and tested this hypothesis with liposome-mediated ex vivo intracoronary IL-10 gene transfer using a functional heterotopic allograft heart transplant model in
Publikováno v:
American Journal of Physiology-Heart and Circulatory Physiology. 281:H1433-H1441
Virus- and nonvirus-mediated immunosuppressive cytokine gene therapy prolongs cardiac allograft survival in various nonfunctional heart transplant animal models, but its cardiac adverse effects have not been addressed. Recently, we developed a functi
Autor:
Paul Chang, Guiggen Cui, Davis C. Drinkwater, Hillel Laks, Xiao Yuen Ma, Frank G Scholl, Luyi Sen, Yoo Sun Hong
Publikováno v:
The Journal of Heart and Lung Transplantation. 20:322-329
Background: Transplant coronary atherosclerosis is a major limiting factor to successful long-term cardiac transplantation. The depletion of tissue plasminogen activator (tPA) in the arteriolar smooth muscle cells has been associated with a higher in
Publikováno v:
Journal of Cardiovascular Pharmacology and Therapeutics. 3:201-207
Background: Increases in QT and JT dispersion have been suggested as indicative of a proarrhythmic potential as a result of heterogeneity in myocardial refractoriness, the reduc tion of which by antiarrhythmic agents might be associated with a benefi
Publikováno v:
Endocrinology. 137:4744-4751
Thyroid hormones play an important role in cardiac electrophysiology. However, the regulation of cardiac ionic channels by thyroid hormones is still unclear. To evaluate the acute effect of 3,3',5-triiode-L-thyronine (T3) on inward rectifier potassiu