Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Luxin Sun"'
Autor:
Erik B. Faber, Luxin Sun, Jian Tang, Emily Roberts, Sornakala Ganeshkumar, Nan Wang, Damien Rasmussen, Abir Majumdar, Laura E. Hirsch, Kristen John, An Yang, Hira Khalid, Jon E. Hawkinson, Nicholas M. Levinson, Vargheese Chennathukuzhi, Daniel A. Harki, Ernst Schönbrunn, Gunda I. Georg
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-13 (2023)
Abstract Compared to most ATP-site kinase inhibitors, small molecules that target an allosteric pocket have the potential for improved selectivity due to the often observed lower structural similarity at these distal sites. Despite their promise, rel
Externí odkaz:
https://doaj.org/article/43490103b21742f1887f75facd34c438
Autor:
Erik B. Faber, Nan Wang, Kristen John, Luxin Sun, Henry L. Wong, David Burban, Rawle Francis, Defeng Tian, Kwon H. Hong, An Yang, Liming Wang, Mazen Elsaid, Hira Khalid, Nicholas M. Levinson, Ernst Schönbrunn, Jon E. Hawkinson, Gunda I. Georg
Publikováno v:
Journal of Medicinal Chemistry. 66:1928-1940
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e8f7407374916699833f89e391662359
https://doi.org/10.1021/acs.jmedchem.2c01731
https://doi.org/10.1021/acs.jmedchem.2c01731
Autor:
Yi Liao, Sean Chin Chan, Eric A. Welsh, Bin Fang, Luxin Sun, Ernst Schönbrunn, John M. Koomen, Derek R. Duckett, Eric B. Haura, Andrii Monastyrskyi, Uwe Rix
Publikováno v:
ACS Chemical Biology. 18:251-264
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3ddcc9b388b97530f774cf0574b653ed
https://doi.org/10.1021/acschembio.2c00587
https://doi.org/10.1021/acschembio.2c00587
Autor:
Erik B. Faber, Nan Wang, Kristen John, Luxin Sun, David Burban, Henry L. Wong, Rawle Francis, Defeng Tian, Kwon H. Hong, An Yang, Liming Wang, Mazen Elsaid, Hira Khalid, Nicholas Levinson, Ernst Schönbrunn, Jon E. Hawkinson, Gunda Georg
Despite the status of cyclin-dependent kinase 2 (CDK2) as a validated target for both anticancer and contraceptive indications, a CDK2 inhibitor with exquisite selectivity has been historically challenging, largely due to the structural similarity of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a40cb086dde45184ebee3b82d2da24e6
https://doi.org/10.26434/chemrxiv-2022-4h8lf-v2
https://doi.org/10.26434/chemrxiv-2022-4h8lf-v2
Autor:
Erik B. Faber, Jian Tang, Emily Roberts, Sornakala Ganeshkumar, Luxin Sun, Nan Wang, Damien Rasmussen, Abir Majumdar, Kristen John, An Yang, Hira Khalid, Jon E. Hawkinson, Nicholas M. Levinson, Ernst Schönbrunn, Vargheese Chennathukuzhi, Daniel A. Harki, Gunda I. Georg
Compared to most ATP-site kinase inhibitors, small molecules that target an allosteric pocket have the potential for improved selectivity due to the often observed lower structural similarity at these distal sites. Despite their promise, relatively f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8a75b00356ddac831362a32d9e2bc925
https://doi.org/10.1101/2022.06.30.497818
https://doi.org/10.1101/2022.06.30.497818
Autor:
Yi Liao, Sean Chin Chan, Eric A. Welsh, Bin Fang, Luxin Sun, Ernst Schönbrunn, John M. Koomen, Derek R. Duckett, Eric B. Haura, Andrii Monastyrskyi, Uwe Rix
Publikováno v:
Cancer Research. 83:3839-3839
A subset of non-small cell lung cancer (NSCLC) patients respond poorly to clinical drugs targeting defined oncogenic driver mutations. To improve the efficacy of these drugs in drug refractory NSCLC, the identification of supporting therapeutic targe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3dd97d674b3684201fc00f8fddec26d7
https://doi.org/10.1158/1538-7445.am2023-3839
https://doi.org/10.1158/1538-7445.am2023-3839
Publikováno v:
Bioorg Med Chem Lett
A monocarboxylic inhibitor was designed and synthesized to disrupt the protein-protein interaction (PPI) between GRB2 and phosphotyrosine-containing proteins. Biochemical characterizations show compound 7 binds with the Src homology 2 (SH2) domain of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::35d3fdb49fb453e8008e001395288412
https://europepmc.org/articles/PMC8526398/
https://europepmc.org/articles/PMC8526398/
Autor:
Jeffrey T. Jensen, Luxin Sun, Ernst Schönbrunn, Carol B. Hanna, Jon E. Hawkinson, Deepti Mudaliar, C. Leigh Allen, Kristen John, Gunda I. Georg
Publikováno v:
Biology of Reproduction
WEE2 oocyte meiosis inhibiting kinase is a well-conserved oocyte specific kinase with a dual regulatory role during meiosis. Active WEE2 maintains immature, germinal vesicle stage oocytes in prophase I arrest prior to the luteinizing hormone surge an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e56a618c5f59026b9af10f314af780e4
https://pubmed.ncbi.nlm.nih.gov/32667031
https://pubmed.ncbi.nlm.nih.gov/32667031
Background: Choledochal cysts are rare congenital or acquired cystic dilation of the intra- or extrahepatic bile ducts. It is well known that choledochal cyst is a precancerous lesion and cancer usually occurs at the site of bile stasis, irritation,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::944517fe25133cc864ea004a9db993f8
https://doi.org/10.31487/j.scr.2018.10.001
https://doi.org/10.31487/j.scr.2018.10.001
Autor:
Yuhao Huang, Andrew N. Blackford, Luxin Sun, J. N. Mark Glover, Wojciech Niedzwiedz, Sukmin Yang, Ross A. Edwards
Topoisomerase IIβ binding protein 1 (TopBP1) is a critical protein-protein interaction hub in DNA replication checkpoint control. It was proposed that TopBP1 BRCT5 interacts with Bloom syndrome helicase (BLM) to regulate genome stability through eit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa3069475fb865761092d367a9f31685
https://doi.org/10.1016/j.str.2017.08.005
https://doi.org/10.1016/j.str.2017.08.005